STRINGSTRING
AOZ97996.1 AOZ97996.1 proA proA proB proB mqo mqo AOZ98184.1 AOZ98184.1 AOZ98315.1 AOZ98315.1 sucC sucC AOZ98333.1 AOZ98333.1 gltD gltD purU purU AOZ98394.1 AOZ98394.1 AOZ98395.1 AOZ98395.1 AOZ98422.1 AOZ98422.1 APA00848.1 APA00848.1 AOZ98461.1 AOZ98461.1 AOZ98468.1 AOZ98468.1 AOZ98562.1 AOZ98562.1 eno eno AOZ98622.1 AOZ98622.1 pdhA pdhA AOZ98644.1 AOZ98644.1 AOZ98708.1 AOZ98708.1 AOZ98755.1 AOZ98755.1 AOZ98800.1 AOZ98800.1 AOZ98855.1 AOZ98855.1 AOZ98856.1 AOZ98856.1 AOZ98877.1 AOZ98877.1 AOZ98913.1 AOZ98913.1 APA00887.1 APA00887.1 AOZ98991.1 AOZ98991.1 proC proC AOZ99117.1 AOZ99117.1 AOZ99153.1 AOZ99153.1 pgk pgk AOZ99261.1 AOZ99261.1 pgi pgi AOZ99310.1 AOZ99310.1 sdhA sdhA AOZ99312.1 AOZ99312.1 AOZ99314.1 AOZ99314.1 fbp fbp gcvH gcvH pckA pckA AOZ99521.1 AOZ99521.1 AOZ99587.1 AOZ99587.1 AOZ99651.1 AOZ99651.1 gpmI gpmI AOZ99715.1 AOZ99715.1 AOZ99823.1 AOZ99823.1 AOZ99824.1 AOZ99824.1 AOZ99840.1 AOZ99840.1 lipB lipB AOZ99916.1 AOZ99916.1 AOZ99917.1 AOZ99917.1 mdh mdh APA00043.1 APA00043.1 lipA lipA APA00144.1 APA00144.1 gcvT gcvT fumC fumC APA00300.1 APA00300.1 APA00363.1 APA00363.1 APA00386.1 APA00386.1 APA00485.1 APA00485.1 APA00493.1 APA00493.1 APA00511.1 APA00511.1 sucD sucD ackA ackA APA00592.1 APA00592.1 APA00605.1 APA00605.1 APA00606.1 APA00606.1 glyA glyA tal tal APA00627.1 APA00627.1 APA00646.1 APA00646.1 pfkA pfkA tpiA tpiA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AOZ97996.1NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (526 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (398 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (253 aa)
mqoMalate:quinone oxidoreductase; Malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (497 aa)
AOZ98184.1Diapophytoene dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
AOZ98315.1Isocitrate dehydrogenase (NADP(+)); Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. (745 aa)
sucCsuccinate--CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa)
AOZ98333.1Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1504 aa)
gltDGlutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (484 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa)
AOZ98394.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
AOZ98395.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
AOZ98422.1FMN-binding glutamate synthase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate synthase family. (502 aa)
APA00848.1Glutamine synthetase type III; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (729 aa)
AOZ98461.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
AOZ98468.1Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
AOZ98562.1Citrate (Si)-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (425 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
AOZ98622.1Glycine dehydrogenase (aminomethyl-transferring); Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvP family. (949 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (332 aa)
AOZ98644.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (546 aa)
AOZ98708.1Class II fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (355 aa)
AOZ98755.1acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (635 aa)
AOZ98800.1RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (114 aa)
AOZ98855.12-oxoglutarate dehydrogenase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (410 aa)
AOZ98856.12-oxoglutarate dehydrogenase E1 component; Derived by automated computational analysis using gene prediction method: Protein Homology. (930 aa)
AOZ98877.1Cold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (64 aa)
AOZ98913.1Ribose-phosphate pyrophosphokinase; Catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
APA00887.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (477 aa)
AOZ98991.1Aldehyde dehydrogenase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (517 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (259 aa)
AOZ99117.1Ribose 5-phosphate isomerase B; Derived by automated computational analysis using gene prediction method: Protein Homology. (143 aa)
AOZ99153.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (533 aa)
pgkPhosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (395 aa)
AOZ99261.1Glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa)
pgiPeptidase M23; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (547 aa)
AOZ99310.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (221 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (666 aa)
AOZ99312.1Succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
AOZ99314.1Nitrilase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
fbpFructose-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FBPase class 1 family. (336 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (529 aa)
AOZ99521.1Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (247 aa)
AOZ99587.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (204 aa)
AOZ99651.11-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (542 aa)
gpmIPhosphoglycerate mutase (2,3-diphosphoglycerate-independent); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (507 aa)
AOZ99715.1Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (220 aa)
AOZ99823.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
AOZ99824.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
AOZ99840.1Alpha-ketoacid dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (325 aa)
lipBLipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (231 aa)
AOZ99916.1Aconitate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (923 aa)
AOZ99917.1Aconitate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (753 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (311 aa)
APA00043.1Type I glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (300 aa)
APA00144.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (360 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
APA00300.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
APA00363.1NADP-dependent malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (760 aa)
APA00386.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (802 aa)
APA00485.1Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (860 aa)
APA00493.1Proline dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
APA00511.1acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (635 aa)
sucDsuccinate--CoA ligase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa)
APA00592.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (697 aa)
APA00605.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (279 aa)
APA00606.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa)
talFructose-6-phosphate aldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (218 aa)
APA00627.1Arginase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the arginase family. (346 aa)
APA00646.1Type I glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (328 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa)
Your Current Organism:
Flavobacterium commune
NCBI taxonomy Id: 1306519
Other names: F. commune, Flavobacterium commune Ekwe and Kim 2018, Flavobacterium communis, Flavobacterium sp. PK15, JCM 32115, KCTC 52562, strain PK15
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