STRINGSTRING
AKZ49596.1 AKZ49596.1 prs prs adhE adhE adhP adhP ackA ackA pgi pgi AKZ49747.1 AKZ49747.1 nanE nanE AKZ49769.1 AKZ49769.1 AKZ51346.1 AKZ51346.1 AKZ49770.1 AKZ49770.1 glkA glkA Rpe Rpe gap gap Fba Fba pgk pgk pflB pflB scrR scrR ScrB ScrB ScrA ScrA AKZ49881.1 AKZ49881.1 ScrK ScrK manA manA nagA nagA tal_2 tal_2 tkt tkt AKZ50042.1 AKZ50042.1 eno eno AKZ50063.1 AKZ50063.1 rpiA rpiA acoA acoA AcoB AcoB AcoC AcoC lpdA lpdA LplB LplB AKZ50322.1 AKZ50322.1 eutD eutD ldh ldh Ddh Ddh OadA2 OadA2 AKZ50365.1 AKZ50365.1 AKZ50367.1 AKZ50367.1 oadB oadB OadA1 OadA1 PgmA PgmA pyk pyk Pfk Pfk AKZ50497.1 AKZ50497.1 glgP glgP malQ malQ MalE MalE MalF MalF malG malG MalA MalA MalD MalD MalC MalC AmyA AmyA AmyB AmyB MalX MalX AKZ50629.1 AKZ50629.1 AKZ50630.1 AKZ50630.1 AKZ50631.1 AKZ50631.1 AKZ50632.1 AKZ50632.1 AKZ50633.1 AKZ50633.1 AKZ50634.1 AKZ50634.1 AKZ50636.1 AKZ50636.1 AKZ50637.1 AKZ50637.1 AKZ50638.1 AKZ50638.1 GapN GapN ptsP ptsP ptsH ptsH nagB nagB gpmA_2 gpmA_2 GlcK GlcK KgdA KgdA AKZ50894.1 AKZ50894.1 AKZ50895.1 AKZ50895.1 IdnO IdnO tpiA tpiA Ppc Ppc AKZ50938.1 AKZ50938.1 AKZ51036.1 AKZ51036.1 acyP acyP AKZ51163.1 AKZ51163.1 PulA PulA DexB DexB msmK msmK AKZ51189.1 AKZ51189.1 AKZ51190.1 AKZ51190.1 PflD PflD AKZ51392.1 AKZ51392.1 hpdA hpdA AKZ51257.1 AKZ51257.1 treC treC treB treB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKZ49596.1Amino acid permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (463 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (320 aa)
adhEAcetaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (880 aa)
adhPEthanol-active dehydrogenase/acetaldehyde-active reductase; Similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
pgiGlucose-6-phosphate isomerase; Functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; Derived by automated computational analysis using gene prediction method: Protein Homology. (449 aa)
AKZ49747.1Regulatory protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (502 aa)
nanEN-acetylmannosamine-6-phosphate 2-epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (234 aa)
AKZ49769.1Sugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
AKZ51346.1Acetylneuraminate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
AKZ49770.1Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
glkAHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (312 aa)
RpeRibulose-phosphate 3-epimerase; Catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase; Also binds human plasminogen. (336 aa)
FbaFructose-bisphosphate aldolase; Catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
pgkPhosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
pflBFormate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (775 aa)
scrRLacI family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
ScrBSucrose-6-phosphate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (479 aa)
ScrAPTS sucrose transporter subunit IIABC; Derived by automated computational analysis using gene prediction method: Protein Homology. (627 aa)
AKZ49881.1endo-beta-N-acetylglucosaminidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (993 aa)
ScrKFructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (294 aa)
manAMannose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the mannose-6-phosphate isomerase type 1 family. (317 aa)
nagAN-acetylglucosamine-6-phosphate deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
tal_2Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (214 aa)
tktTransketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (661 aa)
AKZ50042.1N-acetylmannosamine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (435 aa)
AKZ50063.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (227 aa)
acoAPyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
AcoBPyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
AcoCIron ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
lpdADihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (587 aa)
LplBLipoate--protein ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
AKZ50322.1Ribose-phosphate pyrophosphokinase; Catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
eutDPhosphotransacetylase; In Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (327 aa)
DdhLactate dehydrogenase; Catalyzes the formation of pyruvate from lactate; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
OadA2Converts oxaloacetate to phosphoenolpyruvate using ATP as an energy source; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
AKZ50365.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (104 aa)
AKZ50367.1glutaconyl-CoA decarboxylase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
oadBglutaconyl-CoA decarboxylase subunit beta; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). (373 aa)
OadA1Converts oxaloacetate to phosphoenolpyruvate using ATP as an energy source; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
PgmAPhosphoglucomutase; Catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (572 aa)
pykPyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (500 aa)
Pfk6-phosphofructokinase; Catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
AKZ50497.1Bacteriophage resistance protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (517 aa)
glgPMaltose phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (754 aa)
malQ4-alpha-glucanotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (497 aa)
MalESugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
MalFSugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (453 aa)
malGSugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (278 aa)
MalAMaltodextrose utilization protein malA; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
MalDSugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
MalCSugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
AmyAAlpha-amylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (711 aa)
AmyBAlpha-amylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (567 aa)
MalXSugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (419 aa)
AKZ50629.1Beta-hexosaminidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (596 aa)
AKZ50630.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
AKZ50631.1Converts D-mannonate to D-mannuronate; Derived by automated computational analysis using gene prediction method: Protein Homology. (279 aa)
AKZ50632.1Mannonate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (364 aa)
AKZ50633.1Glucuronate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
AKZ50634.12-dehydro-3-deoxyphosphogluconate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)
AKZ50636.1Beta-glucuronidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (596 aa)
AKZ50637.12-dehydro-3-deoxygluconokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
AKZ50638.1Glucuronide permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (514 aa)
GapNGlyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
ptsPPhosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (577 aa)
ptsHPhosphocarrier protein HPr; Derived by automated computational analysis using gene prediction method: Protein Homology. (87 aa)
nagBGlucosamine-6-phosphate deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
gpmA_2Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (231 aa)
GlcKGlucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
KgdAKeto-deoxy-phosphogluconate aldolase; Catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
AKZ50894.12-dehydro-3-deoxygluconokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
AKZ50895.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
IdnOGluconate 5-dehydrogenase; Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa)
PpcPhosphoenolpyruvate carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (920 aa)
AKZ50938.1PTS beta-glucoside transporter subunit IIABC; Derived by automated computational analysis using gene prediction method: Protein Homology. (620 aa)
AKZ51036.1ADP-ribose pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
acyPAcylphosphatase; Catalyzes the hydrolysis of acylphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (92 aa)
AKZ51163.1Transaldolase; Similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
PulAAmylopullulanase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1165 aa)
DexBGlucan 1,6-alpha-glucosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (535 aa)
msmKSugar ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. (377 aa)
AKZ51189.1Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
AKZ51190.1PTS system glucose/maltose-specific transporter subunit IIBCA; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (728 aa)
PflDFormate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (805 aa)
AKZ51392.1DeoR faimly transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
hpdAPyruvate formate lyase-activating protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
AKZ51257.1Amino acid permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (447 aa)
treCAlpha-amylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (542 aa)
treBPTS system trehalose-specific transporter subunits IIBCA; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (674 aa)
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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