STRINGSTRING
RofA RofA nga nga ifs ifs slo slo SpeG SpeG fasB fasB FasC FasC FasA FasA rnpA rnpA tig tig AKZ49866.1 AKZ49866.1 RocA RocA AKZ50174.1 AKZ50174.1 sptR sptR SptS SptS SrtR SrtR SrtK SrtK ciaH ciaH arlR arlR AKZ50802.1 AKZ50802.1 AKZ50808.1 AKZ50808.1 AKZ50809.1 AKZ50809.1 AKZ50810.1 AKZ50810.1 AKZ50811.1 AKZ50811.1 AKZ50827.1 AKZ50827.1 SmeZ SmeZ vicX vicX vicK vicK vicR vicR SpyA SpyA cepA cepA csrS csrS csrR csrR ska ska SclA SclA AKZ51197.1 AKZ51197.1 scpA-2 scpA-2 mga mga Ihk Ihk Irr Irr speB_2 speB_2 speB speB ropB ropB dnaseB dnaseB HtrA HtrA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RofARegulatory protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (497 aa)
ngaN-acetylglucosamine-1-phosphate uridyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (451 aa)
ifsNAD glycohydrolase inhibitor; Derived by automated computational analysis using gene prediction method: Protein Homology. (161 aa)
sloAlveolysin; Derived by automated computational analysis using gene prediction method: Protein Homology. (574 aa)
SpeGExosortase; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
fasBHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
FasCHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
FasATranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
rnpARibonuclease P; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (119 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (427 aa)
AKZ49866.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (97 aa)
RocAHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (451 aa)
AKZ50174.1GTP pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
sptRTranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
SptSHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
SrtRChemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
SrtKHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
ciaHHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
arlRTranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
AKZ50802.1AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
AKZ50808.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
AKZ50809.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (700 aa)
AKZ50810.1Cytosine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
AKZ50811.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (157 aa)
AKZ50827.1DNAse; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
SmeZExosortase; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
vicXMetallohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (269 aa)
vicKHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (450 aa)
vicRPhoP family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
SpyAADP-ribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
cepAPeptidase S8; Derived by automated computational analysis using gene prediction method: Protein Homology. (1645 aa)
csrSATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (500 aa)
csrRPhoB family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
skaKinase; This protein is not a protease, but it activates plasminogen by complexing with it. As a potential virulence factor, it is thought to prevent the formation of effective fibrin barriers around the site of infection, thereby contributing to the invasiveness of the cells (By similarity). (432 aa)
SclAHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
AKZ51197.1Exotoxin Z; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
scpA-2Peptidase C5; This virulence factor of S.pyogenes specifically cleaves the human serum chemotaxin C5a at '68-Lys-|-Asp-69' bond near its C- terminus, destroying its ability to serve as a chemoattractant. (1164 aa)
mgaM protein trans-acting positive regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (534 aa)
IhkHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
IrrChemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
speB_2Streptopain; Derived by automated computational analysis using gene prediction method: Protein Homology. (101 aa)
speBPeptidase C10; Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing. Belongs to the peptidase C10 family. (398 aa)
ropBXRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
dnaseBMitogenic factor; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
HtrASerine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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