STRINGSTRING
def2 def2 SptS SptS AKZ50212.1 AKZ50212.1 AKZ50224.1 AKZ50224.1 LplB LplB AKZ50268.1 AKZ50268.1 mnmE mnmE AKZ50279.1 AKZ50279.1 SrtK SrtK DpiB DpiB rluD_3 rluD_3 AKZ50335.1 AKZ50335.1 prmC prmC Gid Gid LplA LplA AKZ50396.1 AKZ50396.1 lipL lipL ciaH ciaH AKZ50423.1 AKZ50423.1 truB truB hsdS2 hsdS2 AKZ50484.1 AKZ50484.1 RsuA RsuA AKZ50590.1 AKZ50590.1 AKZ50595.1 AKZ50595.1 AKZ50606.1 AKZ50606.1 AKZ50619.1 AKZ50619.1 Map Map rimL rimL InlA InlA birA birA AKZ50664.1 AKZ50664.1 AKZ50668.1 AKZ50668.1 AKZ50680.1 AKZ50680.1 AKZ50721.1 AKZ50721.1 rlmN rlmN rsmD rsmD AKZ50801.1 AKZ50801.1 AKZ50810.1 AKZ50810.1 AKZ50814.1 AKZ50814.1 AKZ50849.1 AKZ50849.1 PtsK PtsK AKZ50946.1 AKZ50946.1 AKZ50952.1 AKZ50952.1 vicK vicK AKZ50994.1 AKZ50994.1 cypB cypB nrdI nrdI rsmI rsmI AKZ51080.1 AKZ51080.1 AKZ51082.1 AKZ51082.1 AKZ51093.1 AKZ51093.1 csrS csrS lemA lemA rsmG rsmG AKZ51118.1 AKZ51118.1 HsdR HsdR AKZ51128.1 AKZ51128.1 HsdM HsdM AKZ51131.1 AKZ51131.1 rlmB rlmB nrdI-2 nrdI-2 AKZ51192.1 AKZ51192.1 AKZ51204.1 AKZ51204.1 Ihk Ihk AKZ51242.1 AKZ51242.1 mnmG mnmG mnmA mnmA rlmH rlmH tilS tilS AKZ49614.1 AKZ49614.1 AKZ49667.1 AKZ49667.1 dusB dusB tgt tgt AKZ49743.1 AKZ49743.1 rsmA rsmA truA truA tsaB tsaB rimI rimI tsaD tsaD Alr Alr tsaE tsaE trmB trmB AKZ49976.1 AKZ49976.1 rsmH rsmH AKZ50007.1 AKZ50007.1 AKZ50019.1 AKZ50019.1 rsmB rsmB pppL pppL pknB pknB yvqE yvqE AKZ50026.1 AKZ50026.1 AKZ50035.1 AKZ50035.1 AKZ50047.1 AKZ50047.1 thiI thiI AKZ50138.1 AKZ50138.1 trmD trmD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
def2Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins; Belongs to the polypeptide deformylase family. (136 aa)
SptSHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
AKZ50212.1Sulfurtransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
AKZ50224.1SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
LplBLipoate--protein ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
AKZ50268.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (549 aa)
mnmEtRNA modification GTPase MnmE; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa)
AKZ50279.1Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (110 aa)
SrtKHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
DpiBHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
rluD_3Pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (301 aa)
AKZ50335.1Thiamine biosynthesis protein ApbE; Derived by automated computational analysis using gene prediction method: Protein Homology. (312 aa)
prmCSAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (279 aa)
GidtRNA (uracil-5-)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
LplALipoate--protein ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
AKZ50396.1Deacetylase SIR2; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
lipLLipoate--protein ligase; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. (278 aa)
ciaHHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
AKZ50423.1RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
truBtRNA pseudouridine synthase B; Catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; Derived by automated computational analysis using gene prediction method: Protein Homology. (294 aa)
hsdS2Restriction endonuclease subunit S; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
AKZ50484.1Phage portal protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
RsuAPseudouridine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
AKZ50590.1SAM-dependent methlyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
AKZ50595.1Restriction endonuclease subunit M; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
AKZ50606.1Conjugal transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (71 aa)
AKZ50619.1RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
MapMethionine aminopeptidase; Catalyzes the removal of N-terminal amino acids from peptides and arylamides; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
rimLGNAT family acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (180 aa)
InlAInternalin; Derived by automated computational analysis using gene prediction method: Protein Homology. (792 aa)
birAGntR family transcriptional regulator; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (313 aa)
AKZ50664.1Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
AKZ50668.116S rRNA pseudouridylate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
AKZ50680.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
AKZ50721.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (78 aa)
rlmNRibosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (359 aa)
rsmDrRNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)
AKZ50801.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (577 aa)
AKZ50810.1Cytosine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
AKZ50814.1GNAT family acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (59 aa)
AKZ50849.1Phage portal protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
PtsKSerine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
AKZ50946.1histidyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
AKZ50952.1Portal protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
vicKHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (450 aa)
AKZ50994.1Glutamine cyclotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
cypBPeptidylprolyl isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (268 aa)
nrdIRibonucleotide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
rsmI16S rRNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
AKZ51080.1RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (182 aa)
AKZ51082.1Pseudouridine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (240 aa)
AKZ51093.123S rRNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
csrSATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (500 aa)
lemAMembrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
rsmG16S rRNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa)
AKZ51118.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (368 aa)
HsdRDEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (992 aa)
AKZ51128.1Restriction endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
HsdMRestriction endonuclease subunit M; Derived by automated computational analysis using gene prediction method: Protein Homology. (526 aa)
AKZ51131.1SalK; Derived by automated computational analysis using gene prediction method: Protein Homology. (520 aa)
rlmBrRNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
nrdI-2Ribonucleotide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
AKZ51192.1Ribosomal protein L11 methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
AKZ51204.1Histidine triad (HIT) protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (825 aa)
IhkHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
AKZ51242.1Pseudouridylate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)
mnmGtRNA uridine 5-carboxymethylaminomethyl modification protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (632 aa)
mnmAThiouridylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (373 aa)
rlmHSPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
tilStRNA(Ile)-lysidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
AKZ49614.1Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (145 aa)
AKZ49667.1Adenine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
dusBTIM barrel oxidoreductase NifR3; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (325 aa)
tgtQueuine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
AKZ49743.1Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (171 aa)
rsmA16S rRNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
truAPseudouridine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
tsaBPeptidase M22; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
rimIAlanine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (141 aa)
tsaDtRNA threonylcarbamoyladenosine biosynthesis protein Gcp; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (342 aa)
Alr4'-phosphopantetheinyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (118 aa)
tsaEHydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (153 aa)
trmBtRNA (guanine-N7)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (211 aa)
AKZ49976.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
rsmH16S rRNA methyltransferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (316 aa)
AKZ50007.1N-6 DNA methylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
AKZ50019.1methionyl-tRNA formyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
rsmB16S rRNA methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (440 aa)
pppLProtein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (246 aa)
pknBSerine/threonine protein kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (632 aa)
yvqEHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
AKZ50026.1Peptidylprolyl isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (466 aa)
AKZ50035.1RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (451 aa)
AKZ50047.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (574 aa)
thiIThiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (404 aa)
AKZ50138.1Pseudouridine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
trmDtRNA (guanine-N1)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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