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mnmG mnmG tuf tuf mnmE mnmE miaA miaA trmD trmD thiI thiI trmB trmB tsaE tsaE tsaB tsaB truA truA tgt tgt tilS tilS dusB dusB dnaA dnaA truB truB mnmA mnmA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mnmGtRNA uridine 5-carboxymethylaminomethyl modification protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (632 aa)
tufElongation factor Tu; EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
mnmEtRNA modification GTPase MnmE; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa)
miaAtRNA delta(2)-isopentenylpyrophosphate transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
trmDtRNA (guanine-N1)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
thiIThiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (404 aa)
trmBtRNA (guanine-N7)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (211 aa)
tsaEHydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (153 aa)
tsaBPeptidase M22; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
truAPseudouridine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
tgtQueuine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
tilStRNA(Ile)-lysidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
dusBTIM barrel oxidoreductase NifR3; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (325 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (451 aa)
truBtRNA pseudouridine synthase B; Catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; Derived by automated computational analysis using gene prediction method: Protein Homology. (294 aa)
mnmAThiouridylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (373 aa)
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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