STRINGSTRING
dnaA dnaA AKZ49592.1 AKZ49592.1 AKZ49614.1 AKZ49614.1 AtoE AtoE AKZ49690.1 AKZ49690.1 atoD_2 atoD_2 AKZ49692.1 AKZ49692.1 fasB fasB FasA FasA AKZ49808.1 AKZ49808.1 glnA glnA AKZ49914.1 AKZ49914.1 AtoA AtoA AtoD1 AtoD1 AtoB AtoB yvqE yvqE yvqC yvqC RocA RocA AKZ50047.1 AKZ50047.1 AKZ50048.1 AKZ50048.1 AKZ50269.1 AKZ50269.1 SrtR SrtR SrtK SrtK srtA srtA SrtT SrtT AKZ50287.1 AKZ50287.1 AKZ50288.1 AKZ50288.1 srtF srtF SrtE SrtE SrtG SrtG MalP MalP AKZ50311.1 AKZ50311.1 citG_2 citG_2 citD citD citE citE citF citF citX citX citC citC ciaH ciaH arlR arlR pstS pstS dltD dltD dltC dltC dltB dltB dltA dltA AKZ50801.1 AKZ50801.1 vicK vicK vicR vicR AKZ50978.1 AKZ50978.1 salR salR AKZ51131.1 AKZ51131.1 Ihk Ihk Irr Irr HtrA HtrA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (451 aa)
AKZ49592.1Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
AKZ49614.1Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (145 aa)
AtoEShort-chain fatty acid transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
AKZ49690.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (394 aa)
atoD_2Branched-chain amino acid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
AKZ49692.1Acetate CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
fasBHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
FasATranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
AKZ49808.1Competence protein ComX; Derived by automated computational analysis using gene prediction method: Protein Homology. (161 aa)
glnAGlutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
AKZ49914.1D-alanyl-D-alanine carboxypeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
AtoAAcetate CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
AtoD1Branched-chain amino acid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (196 aa)
AtoBacetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
yvqEHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
yvqCLuxR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
RocAHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (451 aa)
AKZ50047.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (574 aa)
AKZ50048.1AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (494 aa)
AKZ50269.1Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
SrtRChemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
SrtKHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
srtALantibiotic streptin; Lanthionine-containing peptide antibiotic (lantibiotic) active on certain Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. (46 aa)
SrtTLantibiotic ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (596 aa)
AKZ50287.1Lanthionine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (414 aa)
AKZ50288.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (988 aa)
srtFLantibiotic ABC transporter ATP-binding protein; Implicated in the export process of the lantibiotic SrtA. (229 aa)
SrtELantibiotic ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
SrtGLantibiotic ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (240 aa)
MalPMalate permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
AKZ50311.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
citG_22-(5'-triphosphoribosyl)-3'-dephospho CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (294 aa)
citDCitrate lyase subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology. (102 aa)
citECitrate lyase subunit beta; citryl-ACP lyase; catalyzes the formation of acetate and oxaloacetate from citrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
citFcitrate-ACP transferase, the alpha subunit catalyzes the formation of (3S)-citryl-CoA from acetyl-CoA and citrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (510 aa)
citXACP synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
citC[citrate [pro-3S]-lyase] ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
ciaHHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
arlRTranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
pstSPhosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
dltDCytochrome C552; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa)
dltCAlanine-phosphoribitol ligase; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. (79 aa)
dltBD-alanyl-lipoteichoic acid biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
dltAAlanine-phosphoribitol ligase; Transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; Derived by automated computational analysis using gene prediction method: Protein Homology. (512 aa)
AKZ50801.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (577 aa)
vicKHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (450 aa)
vicRPhoP family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
AKZ50978.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
salRHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
AKZ51131.1SalK; Derived by automated computational analysis using gene prediction method: Protein Homology. (520 aa)
IhkHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
IrrChemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
HtrASerine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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