(67 nodes) Macroautophagy network (Peniophora sp. CONT)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A166M327	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily. (344 aa)
	A0A165WAY8	Uncharacterized protein. (133 aa)
	A0A165WJD6	APG6-domain-containing protein. (477 aa)
	A0A165WXC8	Uncharacterized protein. (145 aa)
	A0A165X9Z3	Uncharacterized protein. (79 aa)
	MDM34	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. (733 aa)
	A0A165Y0J9	Uncharacterized protein. (198 aa)
	A0A165Y9K8	Class I glutamine amidotransferase-like protein. (235 aa)
	A0A165Y9L6	Class I glutamine amidotransferase-like protein. (236 aa)
	A0A165YAT0	Ubiquitin/40s ribosomal protein S27a fusion. (159 aa)
	A0A165YMA1	Autophagy_act_C domain-containing protein. (192 aa)
	A0A165YMK9	Uncharacterized protein. (209 aa)
	A0A165YNI5	Pkinase-domain-containing protein. (904 aa)
	A0A165YVH3	SET domain-containing protein. (561 aa)
	A0A165Z0M9	Snf7-domain-containing protein. (253 aa)
	A0A165Z125	Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
	A0A165ZAM7	DLIC-domain-containing protein. (554 aa)
	A0A165ZK04	WD40 repeat-like protein. (420 aa)
	A0A166AJ37	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] (673 aa)
	A0A166AM97	Uncharacterized protein. (182 aa)
	A0A166APN0	Non-specific serine/threonine protein kinase. (635 aa)
	A0A166AS89	Uncharacterized protein. (451 aa)
	A0A166AT46	Ca2+-binding EF-hand superfamily protein. (165 aa)
	A0A166AWS8	Uncharacterized protein. (165 aa)
	A0A166BVF3	Carbohydrate-binding module family 48 protein. (571 aa)
	A0A166C4R0	Autophagy-related protein. (126 aa)
	A0A166CCK7	Non-specific serine/threonine protein kinase. (1271 aa)
	A0A166EXH3	Phosphatidylinositol 3-kinase VPS34. (852 aa)
	A0A166F3H1	Uncharacterized protein. (349 aa)
	A0A166FDQ4	WD_REPEATS_REGION domain-containing protein. (482 aa)
	A0A166FIW0	TPR-like protein. (640 aa)
	A0A166FUM1	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (848 aa)
	A0A166G977	TPR-like protein. (375 aa)
	A0A166GF71	Pkinase-domain-containing protein. (1240 aa)
	A0A166GGW7	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. (342 aa)
	A0A166GTJ6	Class I glutamine amidotransferase-like protein. (235 aa)
	A0A166GTL0	Class I glutamine amidotransferase-like protein. (235 aa)
	A0A166H3H8	Phosphatases II. (898 aa)
	A0A166H729	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. (119 aa)
	A0A166HKR0	UBC-like protein. (138 aa)
	A0A166I786	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (281 aa)
	A0A166I8J4	Carbohydrate-binding module family 48 protein. (484 aa)
	A0A166I940	Class I glutamine amidotransferase-like protein. (231 aa)
	A0A166IDD7	Uncharacterized protein. (296 aa)
	A0A166IE43	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (931 aa)
	A0A166IFG0	Uncharacterized protein. (464 aa)
	A0A166IFH2	Uncharacterized protein. (233 aa)
	A0A166IIQ9	Autophagy-related protein 3. (365 aa)
	A0A166IRC9	Mitochondrial import translocase, subunit Tom22. (155 aa)
	A0A166J286	Uncharacterized protein. (1454 aa)
	A0A166J4W8	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily. (852 aa)
	A0A166JD24	TPR-like protein. (710 aa)
	A0A166JF44	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (3044 aa)
	A0A166JLX2	Uncharacterized protein. (988 aa)
	A0A166K0J4	Snf7-domain-containing protein. (214 aa)
	A0A166K1R2	Vacuolar sorting protein Vps24. (214 aa)
	A0A166K376	Uncharacterized protein. (1243 aa)
	A0A166K622	Cysteine proteinase; Belongs to the peptidase C19 family. (692 aa)
	A0A166KD55	Polyubiquitin. (305 aa)
	A0A166KF87	Uncharacterized protein. (240 aa)
	A0A166KF97	ARM repeat-containing protein. (1671 aa)
	A0A166KH68	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. (119 aa)
	A0A166KST6	Tom7-domain-containing protein. (51 aa)
	A0A166KXZ1	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily. (345 aa)
	A0A166L538	ATG11 domain-containing protein. (1352 aa)
	A0A166LL98	ATG16-domain-containing protein. (272 aa)
	A0A166LRC4	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (368 aa)

Your Current Organism:

Peniophora sp. CONT

NCBI taxonomy Id: 1314672
Other names: P. sp. CONT

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A165WAY8	A0A165X9Z3	A0A165WAY8	A0A165X9Z3	Uncharacterized protein.	Uncharacterized protein.	0.481
A0A165WAY8	A0A165YMK9	A0A165WAY8	A0A165YMK9	Uncharacterized protein.	Uncharacterized protein.	0.684
A0A165WAY8	A0A165Z0M9	A0A165WAY8	A0A165Z0M9	Uncharacterized protein.	Snf7-domain-containing protein.	0.695
A0A165WAY8	A0A166IFG0	A0A165WAY8	A0A166IFG0	Uncharacterized protein.	Uncharacterized protein.	0.691
A0A165WAY8	A0A166IFH2	A0A165WAY8	A0A166IFH2	Uncharacterized protein.	Uncharacterized protein.	0.610
A0A165WAY8	A0A166K0J4	A0A165WAY8	A0A166K0J4	Uncharacterized protein.	Snf7-domain-containing protein.	0.681
A0A165WAY8	A0A166K1R2	A0A165WAY8	A0A166K1R2	Uncharacterized protein.	Vacuolar sorting protein Vps24.	0.614
A0A165WJD6	A0A165WXC8	A0A165WJD6	A0A165WXC8	APG6-domain-containing protein.	Uncharacterized protein.	0.425
A0A165WJD6	A0A165YMA1	A0A165WJD6	A0A165YMA1	APG6-domain-containing protein.	Autophagy_act_C domain-containing protein.	0.465
A0A165WJD6	A0A165YNI5	A0A165WJD6	A0A165YNI5	APG6-domain-containing protein.	Pkinase-domain-containing protein.	0.996
A0A165WJD6	A0A165ZK04	A0A165WJD6	A0A165ZK04	APG6-domain-containing protein.	WD40 repeat-like protein.	0.879
A0A165WJD6	A0A166AJ37	A0A165WJD6	A0A166AJ37	APG6-domain-containing protein.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...]	0.689
A0A165WJD6	A0A166AM97	A0A165WJD6	A0A166AM97	APG6-domain-containing protein.	Uncharacterized protein.	0.850
A0A165WJD6	A0A166APN0	A0A165WJD6	A0A166APN0	APG6-domain-containing protein.	Non-specific serine/threonine protein kinase.	0.679
A0A165WJD6	A0A166AS89	A0A165WJD6	A0A166AS89	APG6-domain-containing protein.	Uncharacterized protein.	0.664
A0A165WJD6	A0A166BVF3	A0A165WJD6	A0A166BVF3	APG6-domain-containing protein.	Carbohydrate-binding module family 48 protein.	0.683
A0A165WJD6	A0A166C4R0	A0A165WJD6	A0A166C4R0	APG6-domain-containing protein.	Autophagy-related protein.	0.847
A0A165WJD6	A0A166CCK7	A0A165WJD6	A0A166CCK7	APG6-domain-containing protein.	Non-specific serine/threonine protein kinase.	0.679
A0A165WJD6	A0A166EXH3	A0A165WJD6	A0A166EXH3	APG6-domain-containing protein.	Phosphatidylinositol 3-kinase VPS34.	0.999
A0A165WJD6	A0A166FDQ4	A0A165WJD6	A0A166FDQ4	APG6-domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.607