(23 nodes) DNA replication initiation, and Epsilon DNA polymerase complex network (Neolentinus lepideus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

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co-expression

protein homology

Your Input:
	A0A165MTC2	Uncharacterized protein. (521 aa)
	A0A165NNY0	DBF4-type domain-containing protein. (617 aa)
	A0A165NNZ1	P-loop containing nucleoside triphosphate hydrolase protein. (630 aa)
	A0A165P1B4	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (542 aa)
	A0A165QWQ6	Zf-primase domain-containing protein. (737 aa)
	A0A165R0X6	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (860 aa)
	A0A165RG02	DNA helicase; Belongs to the MCM family. (745 aa)
	A0A165RIF9	DNA helicase; Belongs to the MCM family. (841 aa)
	A0A165RTI6	DNA helicase; Belongs to the MCM family. (899 aa)
	A0A165RZJ7	Uncharacterized protein. (524 aa)
	A0A165S2D5	DNA helicase; Belongs to the MCM family. (967 aa)
	A0A165SGX9	DNA polymerase. (1472 aa)
	A0A165ST28	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (417 aa)
	A0A165SYS6	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2232 aa)
	A0A165T8V8	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (501 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (795 aa)
	A0A165UEM9	Origin recognition complex subunit 2. (399 aa)
	A0A165UIP2	ORC_WH_C domain-containing protein. (721 aa)
	A0A165UIR4	DNA helicase; Belongs to the MCM family. (980 aa)
	A0A165UP98	CDC45-like protein. (700 aa)
	A0A165UY50	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (571 aa)
	A0A165VCN5	Kinase-like protein. (626 aa)
	A0A165VSH4	Histone-fold-containing protein. (245 aa)

Your Current Organism:

Neolentinus lepideus

NCBI taxonomy Id: 1314782
Other names: N. lepideus HHB14362 ss-1, Neolentinus lepideus HHB14362 ss-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A165MTC2	A0A165NNY0	A0A165MTC2	A0A165NNY0	Uncharacterized protein.	DBF4-type domain-containing protein.	0.888
A0A165MTC2	A0A165NNZ1	A0A165MTC2	A0A165NNZ1	Uncharacterized protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.999
A0A165MTC2	A0A165P1B4	A0A165MTC2	A0A165P1B4	Uncharacterized protein.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.764
A0A165MTC2	A0A165QWQ6	A0A165MTC2	A0A165QWQ6	Uncharacterized protein.	Zf-primase domain-containing protein.	0.901
A0A165MTC2	A0A165R0X6	A0A165MTC2	A0A165R0X6	Uncharacterized protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.999
A0A165MTC2	A0A165RG02	A0A165MTC2	A0A165RG02	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.997
A0A165MTC2	A0A165RIF9	A0A165MTC2	A0A165RIF9	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.994
A0A165MTC2	A0A165RTI6	A0A165MTC2	A0A165RTI6	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.996
A0A165MTC2	A0A165RZJ7	A0A165MTC2	A0A165RZJ7	Uncharacterized protein.	Uncharacterized protein.	0.999
A0A165MTC2	A0A165S2D5	A0A165MTC2	A0A165S2D5	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.994
A0A165MTC2	A0A165SGX9	A0A165MTC2	A0A165SGX9	Uncharacterized protein.	DNA polymerase.	0.746
A0A165MTC2	A0A165ST28	A0A165MTC2	A0A165ST28	Uncharacterized protein.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.908
A0A165MTC2	A0A165SYS6	A0A165MTC2	A0A165SYS6	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.781
A0A165MTC2	A0A165T8V8	A0A165MTC2	A0A165T8V8	Uncharacterized protein.	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.	0.877
A0A165MTC2	A0A165UEM9	A0A165MTC2	A0A165UEM9	Uncharacterized protein.	Origin recognition complex subunit 2.	0.999
A0A165MTC2	A0A165UIP2	A0A165MTC2	A0A165UIP2	Uncharacterized protein.	ORC_WH_C domain-containing protein.	0.999
A0A165MTC2	A0A165UIR4	A0A165MTC2	A0A165UIR4	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.986
A0A165MTC2	A0A165UP98	A0A165MTC2	A0A165UP98	Uncharacterized protein.	CDC45-like protein.	0.946
A0A165MTC2	A0A165UY50	A0A165MTC2	A0A165UY50	Uncharacterized protein.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.796
A0A165MTC2	A0A165VCN5	A0A165MTC2	A0A165VCN5	Uncharacterized protein.	Kinase-like protein.	0.926