(35 nodes) Nuclear DNA replication network (Neolentinus lepideus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A165W2D9	DNA ligase. (649 aa)
	A0A165W6N9	Uncharacterized protein. (590 aa)
	A0A165VQF1	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (363 aa)
	A0A165VN22	Uncharacterized protein. (171 aa)
	A0A165VCN5	Kinase-like protein. (626 aa)
	A0A165UYJ2	CBFD_NFYB_HMF domain-containing protein. (215 aa)
	A0A165UP98	CDC45-like protein. (700 aa)
	A0A165UIR4	DNA helicase; Belongs to the MCM family. (980 aa)
	A0A165UIP2	ORC_WH_C domain-containing protein. (721 aa)
	A0A165UEM9	Origin recognition complex subunit 2. (399 aa)
	A0A165U8A6	Uncharacterized protein. (242 aa)
	A0A165U8A0	GINS complex, Psf1 component. (203 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (795 aa)
	A0A165TPT9	MT-A70-domain-containing protein; Belongs to the MT-A70-like family. (536 aa)
	A0A165T9K6	Uncharacterized protein. (477 aa)
	A0A165T901	DNA ligase. (742 aa)
	A0A165T428	WD40 repeat-like protein. (743 aa)
	A0A165SGX9	DNA polymerase. (1472 aa)
	A0A165S2D5	DNA helicase; Belongs to the MCM family. (967 aa)
	A0A165RZJ7	Uncharacterized protein. (524 aa)
	A0A165RWG5	DUF602-domain-containing protein. (313 aa)
	A0A165RTI6	DNA helicase; Belongs to the MCM family. (899 aa)
	A0A165RIF9	DNA helicase; Belongs to the MCM family. (841 aa)
	A0A165RG02	DNA helicase; Belongs to the MCM family. (745 aa)
	A0A165R7H1	DUF862-domain-containing protein. (652 aa)
	A0A165R079	Phosphatases II. (583 aa)
	A0A165R072	Uncharacterized protein. (154 aa)
	A0A165R068	Uncharacterized protein. (202 aa)
	A0A165QYR0	Uncharacterized protein. (547 aa)
	A0A165QLH3	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (998 aa)
	A0A165PAC5	GINS complex Psf3 component. (190 aa)
	A0A165P1B4	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (542 aa)
	A0A165NNZ1	P-loop containing nucleoside triphosphate hydrolase protein. (630 aa)
	A0A165ND05	Uncharacterized protein. (328 aa)
	A0A165MTC2	Uncharacterized protein. (521 aa)

Your Current Organism:

Neolentinus lepideus

NCBI taxonomy Id: 1314782
Other names: N. lepideus HHB14362 ss-1, Neolentinus lepideus HHB14362 ss-1

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A165MTC2	A0A165NNZ1	A0A165MTC2	A0A165NNZ1	Uncharacterized protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.999
A0A165MTC2	A0A165P1B4	A0A165MTC2	A0A165P1B4	Uncharacterized protein.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.764
A0A165MTC2	A0A165RG02	A0A165MTC2	A0A165RG02	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.997
A0A165MTC2	A0A165RIF9	A0A165MTC2	A0A165RIF9	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.994
A0A165MTC2	A0A165RTI6	A0A165MTC2	A0A165RTI6	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.996
A0A165MTC2	A0A165RZJ7	A0A165MTC2	A0A165RZJ7	Uncharacterized protein.	Uncharacterized protein.	0.999
A0A165MTC2	A0A165S2D5	A0A165MTC2	A0A165S2D5	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.994
A0A165MTC2	A0A165SGX9	A0A165MTC2	A0A165SGX9	Uncharacterized protein.	DNA polymerase.	0.746
A0A165MTC2	A0A165T901	A0A165MTC2	A0A165T901	Uncharacterized protein.	DNA ligase.	0.423
A0A165MTC2	A0A165T9K6	A0A165MTC2	A0A165T9K6	Uncharacterized protein.	Uncharacterized protein.	0.423
A0A165MTC2	A0A165UEM9	A0A165MTC2	A0A165UEM9	Uncharacterized protein.	Origin recognition complex subunit 2.	0.999
A0A165MTC2	A0A165UIP2	A0A165MTC2	A0A165UIP2	Uncharacterized protein.	ORC_WH_C domain-containing protein.	0.999
A0A165MTC2	A0A165UIR4	A0A165MTC2	A0A165UIR4	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.986
A0A165MTC2	A0A165UP98	A0A165MTC2	A0A165UP98	Uncharacterized protein.	CDC45-like protein.	0.946
A0A165MTC2	A0A165VCN5	A0A165MTC2	A0A165VCN5	Uncharacterized protein.	Kinase-like protein.	0.926
A0A165MTC2	A0A165VQF1	A0A165MTC2	A0A165VQF1	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.553
A0A165MTC2	A0A165W2D9	A0A165MTC2	A0A165W2D9	Uncharacterized protein.	DNA ligase.	0.423
A0A165MTC2	MCM7	A0A165MTC2	A0A165TX42	Uncharacterized protein.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.985
A0A165ND05	A0A165P1B4	A0A165ND05	A0A165P1B4	Uncharacterized protein.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.647
A0A165ND05	A0A165SGX9	A0A165ND05	A0A165SGX9	Uncharacterized protein.	DNA polymerase.	0.447