(109 nodes) mRNA surveillance pathway network (Neolentinus lepideus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A165M7A2	DEAD-domain-containing protein; Belongs to the DEAD box helicase family. (564 aa)
	A0A165M8L1	DEAD-domain-containing protein; Belongs to the DEAD box helicase family. (564 aa)
	A0A165MBH0	Uncharacterized protein. (239 aa)
	A0A165MH62	Uncharacterized protein. (401 aa)
	A0A165MU18	Uncharacterized protein. (587 aa)
	A0A165MXE3	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (634 aa)
	A0A165MY67	CPSF_A domain-containing protein. (1438 aa)
	A0A165N2J1	Uncharacterized protein. (69 aa)
	A0A165N3Y4	P-loop containing nucleoside triphosphate hydrolase protein. (676 aa)
	A0A165N843	RRM domain-containing protein. (279 aa)
	A0A165NAC9	DinB_2 domain-containing protein. (207 aa)
	A0A165NL81	NTF2-like protein. (597 aa)
	A0A165NLL6	P-loop containing nucleoside triphosphate hydrolase protein. (194 aa)
	A0A165NPL0	Uncharacterized protein. (696 aa)
	A0A165NQT2	Uncharacterized protein. (836 aa)
	A0A165NS88	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (204 aa)
	A0A165NTG0	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (449 aa)
	A0A165NTQ7	DWNN-domain-containing protein. (565 aa)
	A0A165P1W3	CID domain-containing protein. (582 aa)
	A0A165P1Y5	Protein DOM34 homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (423 aa)
	A0A165P2M3	NACHT domain-containing protein. (601 aa)
	A0A165P392	Uncharacterized protein. (116 aa)
	A0A165P7A8	RNA-binding domain-containing protein. (310 aa)
	A0A165P9P7	Mago nashi protein. (149 aa)
	A0A165PD11	Uncharacterized protein. (96 aa)
	A0A165PD16	Uncharacterized protein. (105 aa)
	A0A165PEY5	Mov34-domain-containing protein. (362 aa)
	A0A165PLB0	Y14 protein. (152 aa)
	A0A165PLG1	Smr domain-containing protein. (613 aa)
	A0A165PXR3	RNA-dependent RNA polymerase. (1207 aa)
	A0A165Q7P5	Serine/threonine-protein phosphatase. (306 aa)
	A0A165Q993	P-loop containing nucleoside triphosphate hydrolase protein. (437 aa)
	A0A165QEC1	RRM domain-containing protein. (374 aa)
	A0A165QLU5	Uncharacterized protein. (140 aa)
	A0A165QLX3	Smr domain-containing protein. (747 aa)
	A0A165QVJ7	Uncharacterized protein. (969 aa)
	A0A165QYG9	P-loop containing nucleoside triphosphate hydrolase protein. (884 aa)
	A0A165R1R1	Uncharacterized protein. (133 aa)
	A0A165R1S3	RNA-binding domain-containing protein. (342 aa)
	A0A165R1S8	Suf-domain-containing protein. (874 aa)
	A0A165RB47	RRM domain-containing protein. (276 aa)
	A0A165RC84	RRM domain-containing protein. (130 aa)
	A0A165RDA1	DUF667 domain-containing protein. (254 aa)
	A0A165RDT0	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
	A0A165RDY9	RRM domain-containing protein. (239 aa)
	A0A165RKM5	P-loop containing nucleoside triphosphate hydrolase protein. (628 aa)
	A0A165RN43	WD40 repeat-like protein. (551 aa)
	A0A165RNX4	Peptide chain release factor eRF/aRF subunit 1. (438 aa)
	A0A165RS40	Fumarate reductase; Irreversibly catalyzes the reduction of fumarate to succinate. (578 aa)
	A0A165RSM3	ARM repeat-containing protein. (1138 aa)
	A0A165RZ21	Ssu72-domain-containing protein. (272 aa)
	A0A165RZH0	Mago-bind domain-containing protein. (79 aa)
	A0A165S1G1	Tr-type G domain-containing protein. (620 aa)
	A0A165SB29	RRM domain-containing protein. (333 aa)
	A0A165SDL3	RNA-binding domain-containing protein. (168 aa)
	A0A165SJX3	Uncharacterized protein. (405 aa)
	A0A165SJY7	DRMBL-domain-containing protein. (502 aa)
	A0A165STL8	PWI domain-containing protein. (497 aa)
	A0A165STW1	NACHT domain-containing protein. (557 aa)
	A0A165SVZ2	RRM domain-containing protein. (210 aa)
	A0A165SW34	Uncharacterized protein. (795 aa)
	A0A165T0P5	Uncharacterized protein. (574 aa)
	A0A165T7S3	Nuclear cap-binding protein subunit 2. (225 aa)
	A0A165T8G0	ARM repeat-containing protein. (986 aa)
	A0A165T959	Uncharacterized protein. (542 aa)
	A0A165TA88	mRNA-capping enzyme subunit alpha; Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate; Belongs to the eukaryotic GTase family. (432 aa)
	A0A165TCF8	mRNA cap 0 methyltransferase domain-containing protein. (672 aa)
	A0A165TE18	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (687 aa)
	CLP1	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation. (499 aa)
	A0A165TLB2	Uncharacterized protein. (413 aa)
	A0A165TN45	Uncharacterized protein. (202 aa)
	A0A165TN95	RNA-binding domain-containing protein. (191 aa)
	A0A165TQW0	Tr-type G domain-containing protein. (635 aa)
	A0A165TRK3	Uncharacterized protein. (875 aa)
	A0A165TS38	Pinin_SDK_memA domain-containing protein. (324 aa)
	A0A165TXG9	RNA-dependent RNA polymerase. (1201 aa)
	A0A165TYV0	FAD/NAD(P)-binding domain-containing protein. (516 aa)
	A0A165U5B2	Fip1-domain-containing protein. (442 aa)
	A0A165U5V1	NTF2-like protein. (156 aa)
	A0A165U8I8	Uncharacterized protein. (859 aa)
	A0A165U979	Uncharacterized protein. (258 aa)
	A0A165U9X4	Uncharacterized protein. (1160 aa)
	A0A165UII7	Smg4_UPF3 domain-containing protein. (437 aa)
	A0A165UMZ2	Uncharacterized protein. (591 aa)
	A0A165UNJ8	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (716 aa)
	A0A165UNY5	Actin depolymerizing protein. (335 aa)
	A0A165UR80	PINc domain-containing protein. (1106 aa)
	A0A165V5K8	Metallo-hydrolase/oxidoreductase. (779 aa)
	A0A165V7E1	DEAD-domain-containing protein; Belongs to the DEAD box helicase family. (396 aa)
	A0A165V938	Cleavage and polyadenylation specificity factor subunit 2. (926 aa)
	A0A165V9V0	Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (622 aa)
	A0A165VAR6	RRM domain-containing protein. (309 aa)
	A0A165VB49	Uncharacterized protein. (465 aa)
	A0A165VC47	Uncharacterized protein. (282 aa)
	A0A165VHG5	DEAD-domain-containing protein; Belongs to the DEAD box helicase family. (465 aa)
	A0A165VI41	WD40 repeat-like protein. (400 aa)
	A0A165VJI1	Metallo-dependent phosphatase. (406 aa)
	A0A165VJW9	AAA_12 domain-containing protein. (135 aa)
	A0A165VJX8	P-loop containing nucleoside triphosphate hydrolase protein. (653 aa)
	A0A165VLD9	Uncharacterized protein. (170 aa)
	A0A165VMX3	Glycoside hydrolase family 79 protein. (528 aa)
	A0A165VWP1	Mago nashi protein. (149 aa)
	A0A165VYI5	ARM repeat-containing protein. (594 aa)
	A0A165VZY1	Ndufb11, NADH dehydrogenase 1 beta subcomplex subunit. (112 aa)
	A0A165W0P3	Uncharacterized protein. (288 aa)
	A0A165W0T5	NUFIP1 domain-containing protein. (453 aa)
	A0A165W263	Serine/threonine-protein phosphatase. (502 aa)
	A0A165W3Y6	DUF866-domain-containing protein. (162 aa)
	A0A165W881	Uncharacterized protein. (577 aa)

Your Current Organism:

Neolentinus lepideus

NCBI taxonomy Id: 1314782
Other names: N. lepideus HHB14362 ss-1, Neolentinus lepideus HHB14362 ss-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A165M7A2	A0A165N843	A0A165M7A2	A0A165N843	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	RRM domain-containing protein.	0.416
A0A165M7A2	A0A165NL81	A0A165M7A2	A0A165NL81	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	NTF2-like protein.	0.574
A0A165M7A2	A0A165NS88	A0A165M7A2	A0A165NS88	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	0.448
A0A165M7A2	A0A165P1W3	A0A165M7A2	A0A165P1W3	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	CID domain-containing protein.	0.508
A0A165M7A2	A0A165P392	A0A165M7A2	A0A165P392	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.607
A0A165M7A2	A0A165P9P7	A0A165M7A2	A0A165P9P7	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	Mago nashi protein.	0.645
A0A165M7A2	A0A165PLB0	A0A165M7A2	A0A165PLB0	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	Y14 protein.	0.743
A0A165M7A2	A0A165QEC1	A0A165M7A2	A0A165QEC1	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	RRM domain-containing protein.	0.420
A0A165M7A2	A0A165RB47	A0A165M7A2	A0A165RB47	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	RRM domain-containing protein.	0.604
A0A165M7A2	A0A165RC84	A0A165M7A2	A0A165RC84	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	RRM domain-containing protein.	0.604
A0A165M7A2	A0A165RDY9	A0A165M7A2	A0A165RDY9	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	RRM domain-containing protein.	0.604
A0A165M7A2	A0A165RSM3	A0A165M7A2	A0A165RSM3	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	ARM repeat-containing protein.	0.571
A0A165M7A2	A0A165SB29	A0A165M7A2	A0A165SB29	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	RRM domain-containing protein.	0.604
A0A165M7A2	A0A165STL8	A0A165M7A2	A0A165STL8	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	PWI domain-containing protein.	0.572
A0A165M7A2	A0A165SVZ2	A0A165M7A2	A0A165SVZ2	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	RRM domain-containing protein.	0.604
A0A165M7A2	A0A165SW34	A0A165M7A2	A0A165SW34	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.607
A0A165M7A2	A0A165T0P5	A0A165M7A2	A0A165T0P5	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.594
A0A165M7A2	A0A165T7S3	A0A165M7A2	A0A165T7S3	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	Nuclear cap-binding protein subunit 2.	0.659
A0A165M7A2	A0A165T959	A0A165M7A2	A0A165T959	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.420
A0A165M7A2	A0A165TE18	A0A165M7A2	A0A165TE18	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.	0.607