(13 nodes) Mixed, incl. Sensing of DNA Double Strand Breaks, and DNA double-strand break processing network (Rhizopogon vinicolor)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1B7MXJ2	Dna2-domain-containing protein. (1083 aa)
	A0A1B7MZY8	Uncharacterized protein. (1304 aa)
	A0A1B7N250	Tudor_3 domain-containing protein. (1194 aa)
	A0A1B7N7M7	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (811 aa)
	A0A1B7N9J6	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (3044 aa)
	A0A1B7N9T6	Uncharacterized protein. (437 aa)
	A0A1B7N9V1	PIN domain-like protein. (317 aa)
	A0A1B7NAL7	Uncharacterized protein. (860 aa)
	A0A1B7NEC1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1987 aa)
	A0A1B7NFQ7	BRCT domain-containing protein. (360 aa)
	A0A1B7NFR0	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
	A0A1B7NFV4	SAE2 domain-containing protein. (161 aa)
	A0A1B7NHD1	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (716 aa)

Your Current Organism:

Rhizopogon vinicolor

NCBI taxonomy Id: 1314800
Other names: R. vinicolor AM-OR11-026, Rhizopogon vinicolor AM-OR11-026

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1B7MXJ2	A0A1B7MZY8	Dna2-domain-containing protein.	Uncharacterized protein.	0.666
A0A1B7MXJ2	A0A1B7N250	Dna2-domain-containing protein.	Tudor_3 domain-containing protein.	0.691
A0A1B7MXJ2	A0A1B7N7M7	Dna2-domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.877
A0A1B7MXJ2	A0A1B7N9J6	Dna2-domain-containing protein.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.870
A0A1B7MXJ2	A0A1B7N9T6	Dna2-domain-containing protein.	Uncharacterized protein.	0.890
A0A1B7MXJ2	A0A1B7N9V1	Dna2-domain-containing protein.	PIN domain-like protein.	0.890
A0A1B7MXJ2	A0A1B7NAL7	Dna2-domain-containing protein.	Uncharacterized protein.	0.732
A0A1B7MXJ2	A0A1B7NEC1	Dna2-domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.704
A0A1B7MXJ2	A0A1B7NFQ7	Dna2-domain-containing protein.	BRCT domain-containing protein.	0.582
A0A1B7MXJ2	A0A1B7NFR0	Dna2-domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.866
A0A1B7MXJ2	A0A1B7NFV4	Dna2-domain-containing protein.	SAE2 domain-containing protein.	0.716
A0A1B7MXJ2	A0A1B7NHD1	Dna2-domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.877
A0A1B7MZY8	A0A1B7MXJ2	Uncharacterized protein.	Dna2-domain-containing protein.	0.666
A0A1B7MZY8	A0A1B7N250	Uncharacterized protein.	Tudor_3 domain-containing protein.	0.865
A0A1B7MZY8	A0A1B7N7M7	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.923
A0A1B7MZY8	A0A1B7N9J6	Uncharacterized protein.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.988
A0A1B7MZY8	A0A1B7N9T6	Uncharacterized protein.	Uncharacterized protein.	0.923
A0A1B7MZY8	A0A1B7N9V1	Uncharacterized protein.	PIN domain-like protein.	0.923
A0A1B7MZY8	A0A1B7NAL7	Uncharacterized protein.	Uncharacterized protein.	0.809
A0A1B7MZY8	A0A1B7NEC1	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.947