STRINGSTRING
AMK21106.1 AMK21106.1 AMK21383.1 AMK21383.1 AMK21389.1 AMK21389.1 AMK21394.1 AMK21394.1 AMK21469.1 AMK21469.1 AMK21591.1 AMK21591.1 AMK22239.1 AMK22239.1 AMK22253.1 AMK22253.1 AMK22254.1 AMK22254.1 sdhA sdhA AMK22274.1 AMK22274.1 AMK22275.1 AMK22275.1 AMK22293.1 AMK22293.1 accA accA AMK22356.1 AMK22356.1 sucC sucC AMK22511.1 AMK22511.1 AMK22512.1 AMK22512.1 AMK22513.1 AMK22513.1 AMK22573.1 AMK22573.1 fumC fumC AMK22738.1 AMK22738.1 AMK22742.1 AMK22742.1 purU-2 purU-2 AMK22937.1 AMK22937.1 ackA ackA AMK22995.1 AMK22995.1 AMK23107.1 AMK23107.1 pdhA pdhA AMK23329.1 AMK23329.1 AMK23420.1 AMK23420.1 glsA glsA AMK23540.1 AMK23540.1 accD accD murI murI AMK23685.1 AMK23685.1 AMK23706.1 AMK23706.1 AMK23748.1 AMK23748.1 AMK23750.1 AMK23750.1 AMK23841.1 AMK23841.1 AMK23864.1 AMK23864.1 AMK23894.1 AMK23894.1 AMK23904.1 AMK23904.1 AMK23905.1 AMK23905.1 sucA sucA sucD sucD mdh mdh sdhB sdhB proC proC acsA acsA AMK24105.1 AMK24105.1 purU purU proB proB AMK24415.1 AMK24415.1 AMK24569.1 AMK24569.1 ackA-2 ackA-2 AMK24784.1 AMK24784.1 proA proA acsA-2 acsA-2 AMK24992.1 AMK24992.1 AMK24993.1 AMK24993.1 AMK25118.1 AMK25118.1 AMK25225.1 AMK25225.1 AMK25302.1 AMK25302.1 AMK25319.1 AMK25319.1 AMK25340.1 AMK25340.1 AMK25535.1 AMK25535.1 AMK25536.1 AMK25536.1 AMK25537.1 AMK25537.1 AMK25538.1 AMK25538.1 AMK25539.1 AMK25539.1 AMK25540.1 AMK25540.1 acsA-3 acsA-3 AMK25579.1 AMK25579.1 AMK25582.1 AMK25582.1 AMK25596.1 AMK25596.1 AMK25609.1 AMK25609.1 AMK25627.1 AMK25627.1 AMK25635.1 AMK25635.1 AMK25765.1 AMK25765.1 acsA-4 acsA-4 AMK25946.1 AMK25946.1 AMK25959.1 AMK25959.1 AMK25974.1 AMK25974.1 AMK25975.1 AMK25975.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AMK21106.1COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits. (1155 aa)
AMK21383.1COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (51 aa)
AMK21389.1COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (73 aa)
AMK21394.1COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (145 aa)
AMK21469.1Succinate CoA transferase; COG0427 Acetyl-CoA hydrolase. (503 aa)
AMK21591.1COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. (278 aa)
AMK22239.1COG1011 Predicted hydrolase (HAD superfamily). (210 aa)
AMK22253.1COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. (110 aa)
AMK22254.1COG2142 Succinate dehydrogenase, hydrophobic anchor subunit. (129 aa)
sdhACOG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (600 aa)
AMK22274.1acetyl-CoA carboxylase biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa)
AMK22275.1acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (154 aa)
AMK22293.1COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. (271 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (314 aa)
AMK22356.1Response regulator receiver protein; COG0784 FOG: CheY-like receiver. (549 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (399 aa)
AMK22511.1COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (435 aa)
AMK22512.1COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (354 aa)
AMK22513.1Branched-chain alpha-keto acid dehydrogenase subunit E2; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (423 aa)
AMK22573.1COG0372 Citrate synthase; Belongs to the citrate synthase family. (428 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
AMK22738.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (388 aa)
AMK22742.1COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (506 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa)
AMK22937.1Succinate CoA transferase; COG0427 Acetyl-CoA hydrolase. (503 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (403 aa)
AMK22995.1Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; COG2030 Acyl dehydratase. (474 aa)
AMK23107.1COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). (297 aa)
pdhAPyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (355 aa)
AMK23329.1Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (451 aa)
AMK23420.1Malate dehydrogenase; COG0281 Malic enzyme. (755 aa)
glsACOG2066 Glutaminase; Belongs to the glutaminase family. (312 aa)
AMK23540.1COG1254 Acylphosphatases. (93 aa)
accDacetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (267 aa)
AMK23685.1COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (491 aa)
AMK23706.1COG0174 Glutamine synthetase. (470 aa)
AMK23748.1COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (464 aa)
AMK23750.1Pyruvate dehydrogenase E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (428 aa)
AMK23841.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (889 aa)
AMK23864.1COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (490 aa)
AMK23894.1COG0538 Isocitrate dehydrogenases; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (406 aa)
AMK23904.1COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (466 aa)
AMK23905.12-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (415 aa)
sucACOG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes. (931 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
sdhBCOG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (262 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (650 aa)
AMK24105.1COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (483 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (296 aa)
proBGamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (376 aa)
AMK24415.1COG2902 NAD-specific glutamate dehydrogenase. (1551 aa)
AMK24569.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (506 aa)
ackA-2Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
AMK24784.1Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; COG2030 Acyl dehydratase. (473 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (421 aa)
acsA-2Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (647 aa)
AMK24992.1Dihydropyrimidine dehydrogenase subunit A; COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. (483 aa)
AMK24993.1COG0067 Glutamate synthase domain 1. (1512 aa)
AMK25118.1COG0281 Malic enzyme. (753 aa)
AMK25225.1Bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1203 aa)
AMK25302.1FAD binding domain-containing protein 15; COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (556 aa)
AMK25319.1COG1012 NAD-dependent aldehyde dehydrogenases. (499 aa)
AMK25340.1Acetamidase/formamidase; COG0675 Transposase and inactivated derivatives. (435 aa)
AMK25535.1Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Belongs to the FdhD family. (262 aa)
AMK25536.1NAD-dependent formate dehydrogenase delta subunit. (78 aa)
AMK25537.1Formate dehydrogenase subunit alpha; COG3383 Uncharacterized anaerobic dehydrogenase. (948 aa)
AMK25538.1NAD-dependent formate dehydrogenase beta subunit; COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit. (529 aa)
AMK25539.1COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. (159 aa)
AMK25540.1Hypothetical protein. (81 aa)
acsA-3Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (647 aa)
AMK25579.1COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (484 aa)
AMK25582.1COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (499 aa)
AMK25596.1COG1042 Acyl-CoA synthetase (NDP forming). (708 aa)
AMK25609.1COG1012 NAD-dependent aldehyde dehydrogenases. (476 aa)
AMK25627.1COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (488 aa)
AMK25635.1COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. (280 aa)
AMK25765.1COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (496 aa)
acsA-4acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (654 aa)
AMK25946.1Putative PQQ-linked alcohol dehydrogenase; COG4993 Glucose dehydrogenase. (575 aa)
AMK25959.1COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (501 aa)
AMK25974.1Dihydrolipoyllysine-residue acetyltransferase; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (431 aa)
AMK25975.1COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component. (780 aa)
Your Current Organism:
Sphingobium sp. TKS
NCBI taxonomy Id: 1315974
Other names: S. sp. TKS
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