STRINGSTRING
PENSUB_13778 PENSUB_13778 PENSUB_13779 PENSUB_13779 PENSUB_13789 PENSUB_13789 PENSUB_13501 PENSUB_13501 PENSUB_13268 PENSUB_13268 PENSUB_13199 PENSUB_13199 PENSUB_13108 PENSUB_13108 PENSUB_13107 PENSUB_13107 PENSUB_13094 PENSUB_13094 PENSUB_12994 PENSUB_12994 PENSUB_12615 PENSUB_12615 PENSUB_12753 PENSUB_12753 PENSUB_12456 PENSUB_12456 PENSUB_12466 PENSUB_12466 PENSUB_11995 PENSUB_11995 PENSUB_12172 PENSUB_12172 PENSUB_11687 PENSUB_11687 PENSUB_11045 PENSUB_11045 PENSUB_11122 PENSUB_11122 PENSUB_10876 PENSUB_10876 PENSUB_10954 PENSUB_10954 PENSUB_10988 PENSUB_10988 PENSUB_10623 PENSUB_10623 PENSUB_10742 PENSUB_10742 PENSUB_10408 PENSUB_10408 PENSUB_10394 PENSUB_10394 PENSUB_10381 PENSUB_10381 PENSUB_10188 PENSUB_10188 PENSUB_10262 PENSUB_10262 PENSUB_9545 PENSUB_9545 PENSUB_9110 PENSUB_9110 PENSUB_9156 PENSUB_9156 PENSUB_9239 PENSUB_9239 PENSUB_8499 PENSUB_8499 PENSUB_8576 PENSUB_8576 PENSUB_8572 PENSUB_8572 PENSUB_8049 PENSUB_8049 PENSUB_8102 PENSUB_8102 PENSUB_8215 PENSUB_8215 PENSUB_8003 PENSUB_8003 PENSUB_7818 PENSUB_7818 PENSUB_7662 PENSUB_7662 PENSUB_7506 PENSUB_7506 PENSUB_7589 PENSUB_7589 PENSUB_7587 PENSUB_7587 PENSUB_7588 PENSUB_7588 PENSUB_7628 PENSUB_7628 PENSUB_7418 PENSUB_7418 PENSUB_7452 PENSUB_7452 PENSUB_7210 PENSUB_7210 PENSUB_7197 PENSUB_7197 PENSUB_7116 PENSUB_7116 PENSUB_6787 PENSUB_6787 PENSUB_6786 PENSUB_6786 ADK1 ADK1 PENSUB_6833 PENSUB_6833 PENSUB_6579 PENSUB_6579 PENSUB_6577 PENSUB_6577 PENSUB_6604 PENSUB_6604 PENSUB_6479 PENSUB_6479 PENSUB_6471 PENSUB_6471 PENSUB_6009 PENSUB_6009 PENSUB_6080 PENSUB_6080 PENSUB_5819 PENSUB_5819 PENSUB_5698 PENSUB_5698 PENSUB_5585 PENSUB_5585 PENSUB_4887 PENSUB_4887 PENSUB_4986 PENSUB_4986 PENSUB_4987 PENSUB_4987 PENSUB_4683 PENSUB_4683 PENSUB_4675 PENSUB_4675 PENSUB_4426 PENSUB_4426 PENSUB_4255 PENSUB_4255 PENSUB_3937 PENSUB_3937 PENSUB_3977 PENSUB_3977 AAH1 AAH1 PENSUB_3647 PENSUB_3647 PENSUB_3705 PENSUB_3705 PENSUB_3776 PENSUB_3776 PENSUB_3355 PENSUB_3355 PENSUB_3203 PENSUB_3203 PENSUB_3207 PENSUB_3207 PENSUB_3208 PENSUB_3208 PENSUB_3305 PENSUB_3305 PENSUB_2997 PENSUB_2997 PENSUB_2615 PENSUB_2615 PENSUB_2685 PENSUB_2685 PENSUB_2709 PENSUB_2709 PENSUB_2396 PENSUB_2396 PENSUB_2094 PENSUB_2094 PENSUB_2120 PENSUB_2120 PENSUB_1830 PENSUB_1830 PENSUB_1620 PENSUB_1620 PENSUB_1128 PENSUB_1128 PENSUB_1131 PENSUB_1131 PENSUB_1272 PENSUB_1272 PENSUB_695 PENSUB_695 PENSUB_552 PENSUB_552 PENSUB_370 PENSUB_370 PENSUB_14086 PENSUB_14086 PENSUB_14102 PENSUB_14102 ADK2 ADK2 PENSUB_11397 PENSUB_11397 PENSUB_5486 PENSUB_5486 PENSUB_4700 PENSUB_4700 PENSUB_2192 PENSUB_2192
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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PENSUB_13778Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation. (177 aa)
PENSUB_13779Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (185 aa)
PENSUB_13789Uracil phosphoribosyltransferase. (245 aa)
PENSUB_13501Mannosylglucosyl-3-phosphoglycerate phosphatase. (1270 aa)
PENSUB_13268GMP synthase [glutamine-hydrolyzing]. (766 aa)
PENSUB_13199Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (549 aa)
PENSUB_13108GTP cyclohydrolase 1. (249 aa)
PENSUB_13107Adenine phosphoribosyltransferase. (1168 aa)
PENSUB_13094Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family. (414 aa)
PENSUB_12994Nudix hydrolase 1. (115 aa)
PENSUB_12615Uncharacterized protein. (132 aa)
PENSUB_12753Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (572 aa)
PENSUB_12456Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (170 aa)
PENSUB_12466Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (553 aa)
PENSUB_11995Uridine nucleosidase. (305 aa)
PENSUB_12172Riboflavin synthase. (233 aa)
PENSUB_11687Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (212 aa)
PENSUB_11045Folic acid synthesis protein fol1. (527 aa)
PENSUB_11122Bifunctional purine biosynthesis protein ADE17. (593 aa)
PENSUB_10876Deoxycytidylate deaminase. (347 aa)
PENSUB_10954FAD-linked oxidoreductase. (1146 aa)
PENSUB_10988Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (858 aa)
PENSUB_10623Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (612 aa)
PENSUB_10742Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (483 aa)
PENSUB_10408Uncharacterized protein. (392 aa)
PENSUB_10394Uracil phosphoribosyltransferase. (236 aa)
PENSUB_10381DAO domain-containing protein. (479 aa)
PENSUB_10188Dihydrofolate reductase. (286 aa)
PENSUB_10262C-1-tetrahydrofolate synthase, mitochondrial. (938 aa)
PENSUB_9545Dihydrofolate reductase. (274 aa)
PENSUB_9110AB hydrolase-1 domain-containing protein. (370 aa)
PENSUB_9156Bifunctional purine biosynthetic protein ADE1. (803 aa)
PENSUB_9239Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (309 aa)
PENSUB_8499Xanthine phosphoribosyltransferase 1. (204 aa)
PENSUB_8576Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (439 aa)
PENSUB_8572Thymidylate synthase. (337 aa)
PENSUB_8049Nuclease domain-containing protein 1. (884 aa)
PENSUB_8102Adenosine kinase. (349 aa)
PENSUB_8215Dihydrofolate reductase. (233 aa)
PENSUB_8003Adenine phosphoribosyltransferase. (208 aa)
PENSUB_7818Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (474 aa)
PENSUB_7662Folic acid synthesis protein fol1. (350 aa)
PENSUB_7506Uncharacterized protein. (309 aa)
PENSUB_7589Thymidylate kinase. (223 aa)
PENSUB_7587Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (690 aa)
PENSUB_7588Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (468 aa)
PENSUB_7628GTP cyclohydrolase 1. (349 aa)
PENSUB_7418A_deaminase domain-containing protein. (365 aa)
PENSUB_7452Guanylate kinase. (199 aa)
PENSUB_7210Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (165 aa)
PENSUB_7197AMP deaminase. (845 aa)
PENSUB_7116Protein MAM3. (747 aa)
PENSUB_6787Nudix hydrolase domain-containing protein. (442 aa)
PENSUB_6786Uncharacterized protein. (97 aa)
ADK1Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (258 aa)
PENSUB_6833Thymidylate synthase. (334 aa)
PENSUB_6579Uncharacterized protein. (291 aa)
PENSUB_6577Acid phosphatase. (304 aa)
PENSUB_6604DAO domain-containing protein. (325 aa)
PENSUB_6479Adenosine deaminase-like protein. (304 aa)
PENSUB_6471GTP_cyclohydro2 domain-containing protein. (383 aa)
PENSUB_6009Folylpolyglutamate synthase. (263 aa)
PENSUB_6080Methylenetetrahydrofolate dehydrogenase [NAD(+)]. (334 aa)
PENSUB_5819Coronin; Belongs to the WD repeat coronin family. (615 aa)
PENSUB_5698Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1065 aa)
PENSUB_55856,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (220 aa)
PENSUB_4887ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. (207 aa)
PENSUB_4986Uncharacterized protein. (142 aa)
PENSUB_4987Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (337 aa)
PENSUB_4683Mannosylglucosyl-3-phosphoglycerate phosphatase; Belongs to the 5'-nucleotidase family. (470 aa)
PENSUB_4675Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (403 aa)
PENSUB_4426FSH1 domain-containing protein. (179 aa)
PENSUB_4255Nudix hydrolase 1; Belongs to the Nudix hydrolase family. (136 aa)
PENSUB_3937Ribonucleoside-diphosphate reductase small chain. (407 aa)
PENSUB_3977Uncharacterized protein. (450 aa)
AAH1Adenine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily. (356 aa)
PENSUB_3647TGT domain-containing protein. (60 aa)
PENSUB_3705Dihydrofolate reductase. (222 aa)
PENSUB_3776Bud site selection protein BUD4. (1379 aa)
PENSUB_3355OMPdecase domain-containing protein. (409 aa)
PENSUB_3203Adenosine deaminase CECR1-A. (574 aa)
PENSUB_3207F-box domain-containing protein. (666 aa)
PENSUB_32083,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (230 aa)
PENSUB_3305Protein NIF3-like protein. (372 aa)
PENSUB_2997Phosphoribosylaminoimidazole-succinocarboxamide synthase. (300 aa)
PENSUB_2615Formyltetrahydrofolate deformylase. (287 aa)
PENSUB_2685Uncharacterized protein. (345 aa)
PENSUB_2709Uridine kinase. (140 aa)
PENSUB_2396Golgi apyrase; Belongs to the GDA1/CD39 NTPase family. (790 aa)
PENSUB_2094Uncharacterized protein. (353 aa)
PENSUB_2120Phosphoribosylformylglycinamidine synthase. (1360 aa)
PENSUB_1830Cytosine deaminase. (142 aa)
PENSUB_1620Inosine triphosphate pyrophosphatase. (62 aa)
PENSUB_1128Adenosine kinase. (302 aa)
PENSUB_1131Methylenetetrahydrofolate dehydrogenase [NAD(+)]. (306 aa)
PENSUB_1272Flavoprotein domain-containing protein. (632 aa)
PENSUB_695Amidophosphoribosyltransferase. (571 aa)
PENSUB_552ADSL_C domain-containing protein. (480 aa)
PENSUB_370Phosphoribosylglycinamide formyltransferase. (219 aa)
PENSUB_14086A_deaminase domain-containing protein. (376 aa)
PENSUB_14102Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (479 aa)
ADK2GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (254 aa)
PENSUB_11397Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (470 aa)
PENSUB_5486Uridine kinase. (230 aa)
PENSUB_4700Deoxyuridine 5'-triphosphate nucleotidohydrolase. (195 aa)
PENSUB_2192Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (525 aa)
Your Current Organism:
Penicillium subrubescens
NCBI taxonomy Id: 1316194
Other names: CBS 132785, CBS H-21029, DTO 188-D6, IBT 31985, P. subrubescens
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