(60 nodes) Steroid biosynthesis network (Penicillium subrubescens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PENSUB_13829	Eburicol 14-alpha-demethylase; Belongs to the cytochrome P450 family. (524 aa)
	PENSUB_13685	Fatty acid hydroxylase domain-containing protein 2; Belongs to the sterol desaturase family. (110 aa)
	PENSUB_13490	Uncharacterized protein. (605 aa)
	PENSUB_13321	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating. (412 aa)
	PENSUB_13035	Delta(24(24(1)))-sterol reductase. (541 aa)
	PENSUB_12873	Uncharacterized protein. (256 aa)
	PENSUB_12807	Uncharacterized protein. (470 aa)
	PENSUB_12319	3-beta-hydroxysteroid-Delta(8), Delta(7)-isomerase. (1820 aa)
	PENSUB_11903	Cytochrome P450 61; Belongs to the cytochrome P450 family. (528 aa)
	PENSUB_12020	Delta(14)-sterol reductase. (497 aa)
	PENSUB_12076	O-acyltransferase. (535 aa)
	PENSUB_12024	Uncharacterized protein. (246 aa)
	PENSUB_11535	Methylsterol monooxygenase; Belongs to the sterol desaturase family. (247 aa)
	PENSUB_11867	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (332 aa)
	PENSUB_11240	Ammonium transporter. (563 aa)
	PENSUB_10536	Ammonium transporter 3 member 1. (340 aa)
	PENSUB_10665	Fatty acid hydroxylase domain-containing protein 2; Belongs to the sterol desaturase family. (339 aa)
	PENSUB_10437	Uncharacterized protein. (651 aa)
	PENSUB_10114	Uncharacterized protein. (87 aa)
	PENSUB_10353	Uncharacterized protein. (108 aa)
	PENSUB_9909	Fatty acid hydroxylase domain-containing protein 2; Belongs to the sterol desaturase family. (261 aa)
	PENSUB_9410	Uncharacterized protein. (457 aa)
	PENSUB_9461	Eburicol 14-alpha-demethylase; Belongs to the cytochrome P450 family. (510 aa)
	PENSUB_9147	Uncharacterized protein. (274 aa)
	PENSUB_9233	Delta(7)-sterol 5(6)-desaturase; Belongs to the sterol desaturase family. (352 aa)
	PENSUB_8466	Methylsterol monooxygenase; Belongs to the sterol desaturase family. (295 aa)
	PENSUB_8407	Ammonium transporter 1. (303 aa)
	PENSUB_8091	Abhydro_lipase domain-containing protein. (493 aa)
	PENSUB_7787	Uncharacterized protein. (255 aa)
	PENSUB_7871	Lipase 4. (370 aa)
	PENSUB_7870	Lipase 4. (394 aa)
	PENSUB_7509	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (734 aa)
	PENSUB_6414	Delta(24(24(1)))-sterol reductase. (559 aa)
	PENSUB_6119	Uncharacterized protein. (351 aa)
	PENSUB_6173	Uncharacterized protein. (260 aa)
	PENSUB_5952	Sterol esterase 2. (639 aa)
	PENSUB_5970	Uncharacterized protein. (318 aa)
	PENSUB_5356	Uncharacterized protein. (394 aa)
	PENSUB_4965	Uncharacterized protein. (643 aa)
	PENSUB_4416	Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. (377 aa)
	PENSUB_4218	Ammonium transporter. (477 aa)
	PENSUB_3722	Uncharacterized protein. (751 aa)
	PENSUB_3553	O-acyltransferase. (603 aa)
	PENSUB_2395	Ammonium transporter. (477 aa)
	PENSUB_2228	Uncharacterized protein. (224 aa)
	PENSUB_2114	C-8 sterol isomerase. (108 aa)
	PENSUB_2113	Delta(14)-sterol reductase. (490 aa)
	PENSUB_1862	Patatin-like phospholipase domain-containing protein; Lipid hydrolase; Belongs to the PLPL family. (709 aa)
	PENSUB_1789	Uncharacterized protein. (239 aa)
	PENSUB_1694	Sterol 24-C-methyltransferase. (393 aa)
	PENSUB_1727	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (308 aa)
	PENSUB_1524	Uncharacterized protein. (254 aa)
	PENSUB_1601	3-keto-steroid reductase. (452 aa)
	PENSUB_297	Uncharacterized protein. (264 aa)
	PENSUB_142	Uncharacterized protein. (737 aa)
	PENSUB_133	Emopamil-binding protein-like. (246 aa)
	PENSUB_12	C-8 sterol isomerase. (236 aa)
	PENSUB_13911	Cytochrome P450 61; Belongs to the cytochrome P450 family. (529 aa)
	PENSUB_11484	Uncharacterized protein. (393 aa)
	PENSUB_5829	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating. (349 aa)

Your Current Organism:

Penicillium subrubescens

NCBI taxonomy Id: 1316194
Other names: CBS 132785, CBS H-21029, DTO 188-D6, IBT 31985, P. subrubescens

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PENSUB_10114	PENSUB_10665	A0A1Q5TB01	A0A1Q5T8G3	Uncharacterized protein.	Fatty acid hydroxylase domain-containing protein 2; Belongs to the sterol desaturase family.	0.717
PENSUB_10114	PENSUB_11535	A0A1Q5TB01	A0A1Q5T1Y2	Uncharacterized protein.	Methylsterol monooxygenase; Belongs to the sterol desaturase family.	0.730
PENSUB_10114	PENSUB_11867	A0A1Q5TB01	A0A1Q5T2X5	Uncharacterized protein.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.717
PENSUB_10114	PENSUB_11903	A0A1Q5TB01	A0A1Q5T056	Uncharacterized protein.	Cytochrome P450 61; Belongs to the cytochrome P450 family.	0.690
PENSUB_10114	PENSUB_12	A0A1Q5TB01	A0A1Q5UP50	Uncharacterized protein.	C-8 sterol isomerase.	0.848
PENSUB_10114	PENSUB_12076	A0A1Q5TB01	A0A1Q5T0J5	Uncharacterized protein.	O-acyltransferase.	0.894
PENSUB_10114	PENSUB_13035	A0A1Q5TB01	A0A1Q5SUD6	Uncharacterized protein.	Delta(24(24(1)))-sterol reductase.	0.850
PENSUB_10114	PENSUB_13321	A0A1Q5TB01	A0A1Q5SRH7	Uncharacterized protein.	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating.	0.893
PENSUB_10114	PENSUB_13490	A0A1Q5TB01	A0A1Q5SQT7	Uncharacterized protein.	Uncharacterized protein.	0.730
PENSUB_10114	PENSUB_13685	A0A1Q5TB01	A0A1Q5SNN3	Uncharacterized protein.	Fatty acid hydroxylase domain-containing protein 2; Belongs to the sterol desaturase family.	0.717
PENSUB_10114	PENSUB_13829	A0A1Q5TB01	A0A1Q5SMG1	Uncharacterized protein.	Eburicol 14-alpha-demethylase; Belongs to the cytochrome P450 family.	0.954
PENSUB_10114	PENSUB_13911	A0A1Q5TB01	A0A1Q5UQ20	Uncharacterized protein.	Cytochrome P450 61; Belongs to the cytochrome P450 family.	0.690
PENSUB_10114	PENSUB_1601	A0A1Q5TB01	A0A1Q5UK87	Uncharacterized protein.	3-keto-steroid reductase.	0.904
PENSUB_10114	PENSUB_1694	A0A1Q5TB01	A0A1Q5UJF0	Uncharacterized protein.	Sterol 24-C-methyltransferase.	0.419
PENSUB_10114	PENSUB_1727	A0A1Q5TB01	A0A1Q5UJI2	Uncharacterized protein.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.985
PENSUB_10114	PENSUB_2114	A0A1Q5TB01	A0A1Q5UIQ7	Uncharacterized protein.	C-8 sterol isomerase.	0.848
PENSUB_10114	PENSUB_3553	A0A1Q5TB01	A0A1Q5UEZ5	Uncharacterized protein.	O-acyltransferase.	0.580
PENSUB_10114	PENSUB_3722	A0A1Q5TB01	A0A1Q5UEK3	Uncharacterized protein.	Uncharacterized protein.	0.730
PENSUB_10114	PENSUB_4416	A0A1Q5TB01	A0A1Q5UCN9	Uncharacterized protein.	Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.	0.903
PENSUB_10114	PENSUB_4965	A0A1Q5TB01	A0A1Q5UB43	Uncharacterized protein.	Uncharacterized protein.	0.526