(65 nodes) Ubiquinone and other terpenoid-quinone biosynthesis network (Penicillium subrubescens)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	PENSUB_12936	Uncharacterized protein. (562 aa)
	PENSUB_13428	3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase. (493 aa)
	PENSUB_13429	3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase. (68 aa)
	PENSUB_13620	Uncharacterized protein. (309 aa)
	PENSUB_6496	4-coumarate--CoA ligase-like 7. (561 aa)
	PENSUB_6502	AB hydrolase-1 domain-containing protein. (329 aa)
	PENSUB_9000	3-dmu-9_3-mt domain-containing protein. (165 aa)
	PENSUB_9406	VOC domain-containing protein. (145 aa)
	PAD1	Flavin prenyltransferase PAD1, mitochondrial; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (210 aa)
	PENSUB_9405	VOC domain-containing protein. (220 aa)
	PENSUB_9980	Abhydrolase domain-containing protein C22H12.03. (281 aa)
	PENSUB_8564	4HBT domain-containing protein. (136 aa)
	PENSUB_10303	AB hydrolase-1 domain-containing protein. (295 aa)
	COQ7	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. (245 aa)
	PENSUB_10836	Zn(2)-C6 fungal-type domain-containing protein. (553 aa)
	PENSUB_10806	3-dehydroshikimate dehydratase. (337 aa)
	PENSUB_10710	3-dehydroshikimate dehydratase. (316 aa)
	PENSUB_10645	Tetracenomycin polyketide synthesis hydroxylase TcmG. (539 aa)
	PENSUB_10603	4HBT domain-containing protein. (170 aa)
	PENSUB_10553	Minor allergen Alt a 7. (202 aa)
	PENSUB_11288	Uncharacterized protein. (121 aa)
	PENSUB_11290	Uncharacterized protein. (376 aa)
	COQ6	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (509 aa)
	PENSUB_2648	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (266 aa)
	PENSUB_2703	Uncharacterized protein. (82 aa)
	PENSUB_6535	FAD_binding_3 domain-containing protein. (536 aa)
	PENSUB_1950	Para-nitrophenol 4-monooxygenase. (421 aa)
	PENSUB_2047	Uncharacterized protein. (638 aa)
	PENSUB_1759	3-dehydroshikimate dehydratase. (364 aa)
	PENSUB_6799	4-hydroxybenzoate polyprenyltransferase, mitochondrial. (325 aa)
	PENSUB_7088	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (418 aa)
	PENSUB_7335	3-dehydroshikimate dehydratase. (364 aa)
	PENSUB_7737	4-coumarate--CoA ligase 1. (567 aa)
	PENSUB_7850	FAD-binding PCMH-type domain-containing protein; Belongs to the oxygen-dependent FAD-linked oxidoreductase family. (482 aa)
	PENSUB_8236	2,4-dichlorophenol 6-monooxygenase. (603 aa)
	PENSUB_2258	FAD_binding_3 domain-containing protein. (526 aa)
	PENSUB_3438	Uncharacterized protein. (567 aa)
	PENSUB_343	Uncharacterized protein. (101 aa)
	PENSUB_252	4-hydroxyphenylpyruvate dioxygenase. (413 aa)
	PENSUB_654	Anhydrotetracycline monooxygenase. (524 aa)
	PENSUB_926	4HBT domain-containing protein. (181 aa)
	COQ5	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (315 aa)
	PENSUB_1216	Protein mms22. (2313 aa)
	PENSUB_1107	Aromatic amino acid aminotransferase C56E4.03. (500 aa)
	PENSUB_1472	2,4-dichlorophenol 6-monooxygenase. (488 aa)
	FDC1	Ferulic acid decarboxylase 1; Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4- vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites; Belongs to the UbiD family. UbiD-like/FDC subfamily. (500 aa)
	PENSUB_51	Para-nitrophenol 4-monooxygenase. (409 aa)
	PENSUB_2843	Uncharacterized protein. (476 aa)
	PENSUB_3063	Maltose fermentation regulatory protein. (585 aa)
	PENSUB_3281	Uncharacterized protein. (247 aa)
	PENSUB_3287	3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase. (195 aa)
	COQ3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (349 aa)
	PENSUB_3339	Zn(2)-C6 fungal-type domain-containing protein. (323 aa)
	PENSUB_3468	3-dehydroshikimate dehydratase. (385 aa)
	PENSUB_3561	Acyl-coenzyme A thioesterase 13. (144 aa)
	PENSUB_3791	Uncharacterized protein. (106 aa)
	PENSUB_3997	Uncharacterized protein. (601 aa)
	PENSUB_11534	Methyltransf_25 domain-containing protein. (58 aa)
	PENSUB_4767	4-coumarate--CoA ligase-like 7. (580 aa)
	PENSUB_5959	Abhydrolase domain-containing protein C22H12.03. (198 aa)
	PENSUB_8213	Uncharacterized protein. (1161 aa)
	PENSUB_8214	Carrier domain-containing protein. (1205 aa)
	PENSUB_8181	Capreomycidine synthase. (412 aa)
	PENSUB_8020	Aromatic amino acid aminotransferase. (584 aa)
	PENSUB_12825	4-hydroxybenzoate octaprenyltransferase. (665 aa)

Your Current Organism:

Penicillium subrubescens

NCBI taxonomy Id: 1316194
Other names: CBS 132785, CBS H-21029, DTO 188-D6, IBT 31985, P. subrubescens

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COQ3	COQ5	A0A1Q5UGY4	A0A1Q5UL60	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).	0.827
COQ3	COQ6	A0A1Q5UGY4	A0A1Q5SXK6	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	0.981
COQ3	COQ7	A0A1Q5UGY4	A0A1Q5TAZ6	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.	0.964
COQ3	PENSUB_10645	A0A1Q5UGY4	A0A1Q5T8D2	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Tetracenomycin polyketide synthesis hydroxylase TcmG.	0.558
COQ3	PENSUB_11288	A0A1Q5UGY4	A0A1Q5T4Q8	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Uncharacterized protein.	0.970
COQ3	PENSUB_12825	A0A1Q5UGY4	A0A1Q5SWB6	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	4-hydroxybenzoate octaprenyltransferase.	0.745
COQ3	PENSUB_13428	A0A1Q5UGY4	A0A1Q5SQY8	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase.	0.558
COQ3	PENSUB_13429	A0A1Q5UGY4	A0A1Q5SQV3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase.	0.558
COQ3	PENSUB_13620	A0A1Q5UGY4	A0A1Q5SNH6	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Uncharacterized protein.	0.558
COQ3	PENSUB_1472	A0A1Q5UGY4	A0A1Q5UJU3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	2,4-dichlorophenol 6-monooxygenase.	0.558
COQ3	PENSUB_1950	A0A1Q5UGY4	A0A1Q5UIC6	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Para-nitrophenol 4-monooxygenase.	0.558
COQ3	PENSUB_2258	A0A1Q5UGY4	A0A1Q5URL2	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.558
COQ3	PENSUB_3287	A0A1Q5UGY4	A0A1Q5UFL2	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase.	0.558
COQ3	PENSUB_51	A0A1Q5UGY4	A0A1Q5UP77	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Para-nitrophenol 4-monooxygenase.	0.558
COQ3	PENSUB_6535	A0A1Q5UGY4	A0A1Q5U0Q0	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.558
COQ3	PENSUB_654	A0A1Q5UGY4	A0A1Q5ULZ2	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Anhydrotetracycline monooxygenase.	0.558
COQ3	PENSUB_6799	A0A1Q5UGY4	A0A1Q5TUB8	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	4-hydroxybenzoate polyprenyltransferase, mitochondrial.	0.742
COQ3	PENSUB_7088	A0A1Q5UGY4	A0A1Q5TQ20	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.748
COQ3	PENSUB_7850	A0A1Q5UGY4	A0A1Q5TJJ7	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD-binding PCMH-type domain-containing protein; Belongs to the oxygen-dependent FAD-linked oxidoreductase family.	0.526
COQ3	PENSUB_8236	A0A1Q5UGY4	A0A1Q5TIJ2	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	2,4-dichlorophenol 6-monooxygenase.	0.558