(91 nodes) Propanoate metabolism network (Penicillium subrubescens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PENSUB_2837	2,3-dimethylmalate lyase. (326 aa)
	PENSUB_2912	Acetyl-coenzyme A synthetase. (648 aa)
	PENSUB_2976	SET domain-containing protein 4. (428 aa)
	PENSUB_3076	Secretory component protein SHR3. (218 aa)
	PENSUB_3225	ATP-dependent DNA helicase MER3. (1385 aa)
	PENSUB_3789	S-(Hydroxymethyl)glutathione dehydrogenase. (447 aa)
	PENSUB_3742	Acetyl-CoA carboxylase. (2295 aa)
	PENSUB_4038	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (472 aa)
	PENSUB_4020	Uncharacterized protein. (123 aa)
	PENSUB_4207	Succinyl-CoA ligase [ADP-forming] subunit beta. (463 aa)
	PENSUB_5666	Epimerase domain-containing protein. (350 aa)
	PENSUB_5693	S-(Hydroxymethyl)glutathione dehydrogenase. (380 aa)
	PENSUB_10017	Dihydrolipoyl dehydrogenase. (513 aa)
	PENSUB_13625	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (695 aa)
	PENSUB_13582	PLD phosphodiesterase domain-containing protein. (363 aa)
	PENSUB_13622	Uncharacterized protein. (231 aa)
	PENSUB_13621	Uncharacterized protein. (81 aa)
	PENSUB_13547	Epimerase domain-containing protein. (330 aa)
	PENSUB_13487	Acetyl-CoA acetyltransferase A, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa)
	PENSUB_13486	Uncharacterized protein. (719 aa)
	PENSUB_13269	Bifunctional dihydroflavonol 4-reductase/flavanone 4-reductase. (288 aa)
	PENSUB_13228	Carboxyvinyl-carboxyphosphonate phosphorylmutase. (308 aa)
	PENSUB_12950	Uncharacterized protein. (474 aa)
	PENSUB_12949	Epimerase domain-containing protein. (335 aa)
	PENSUB_12916	Uncharacterized protein. (253 aa)
	PENSUB_12820	Aldehyde reductase 2. (210 aa)
	PENSUB_12795	Alcohol dehydrogenase. (322 aa)
	PENSUB_12821	Uncharacterized protein. (108 aa)
	PENSUB_12720	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial. (590 aa)
	PENSUB_12066	Decarboxylase DEC1. (265 aa)
	PENSUB_12034	Uncharacterized protein. (116 aa)
	PENSUB_12124	ADH_N domain-containing protein. (402 aa)
	PENSUB_11557	Acetyl-CoA acetyltransferase IB; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
	PENSUB_11343	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (687 aa)
	PENSUB_10937	Epimerase domain-containing protein. (360 aa)
	PENSUB_10566	3-hydroxypropionyl-coenzyme A dehydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (274 aa)
	PENSUB_10555	Epimerase domain-containing protein. (331 aa)
	PENSUB_9964	Uncharacterized protein. (220 aa)
	PENSUB_9277	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (395 aa)
	PENSUB_9123	Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial. (312 aa)
	PENSUB_9089	Epimerase domain-containing protein. (347 aa)
	PENSUB_9028	Uncharacterized protein. (150 aa)
	PENSUB_9027	Uncharacterized protein. (108 aa)
	PENSUB_8505	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (444 aa)
	PENSUB_8653	Peroxisomal hydratase-dehydrogenase-epimerase. (899 aa)
	PENSUB_8721	Probable acetate kinase. (418 aa)
	PENSUB_8142	4-aminobutyrate aminotransferase. (83 aa)
	PENSUB_8143	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (416 aa)
	PENSUB_8195	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (331 aa)
	PENSUB_7532	S-(Hydroxymethyl)glutathione dehydrogenase. (448 aa)
	PENSUB_7622	Alcohol dehydrogenase. (357 aa)
	PENSUB_7114	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial. (381 aa)
	PENSUB_7055	3-hydroxyisobutyrate dehydrogenase, mitochondrial. (307 aa)
	PENSUB_6661	Uncharacterized protein. (2013 aa)
	PENSUB_6266	Uncharacterized protein. (453 aa)
	PENSUB_6425	SET domain-containing protein 8. (477 aa)
	PENSUB_5791	S-(Hydroxymethyl)glutathione dehydrogenase. (314 aa)
	PENSUB_5740	L-lactate dehydrogenase A. (242 aa)
	PENSUB_5743	Alcohol dehydrogenase. (167 aa)
	PENSUB_4740	Propionyl-CoA carboxylase beta chain, mitochondrial. (555 aa)
	PENSUB_1506	Peroxisomal acyl-coenzyme A oxidase 1. (544 aa)
	PENSUB_1462	Extracellular metalloprotease. (368 aa)
	PENSUB_1770	Epimerase domain-containing protein. (331 aa)
	PENSUB_1912	Uncharacterized protein. (437 aa)
	PENSUB_1913	Uncharacterized protein. (268 aa)
	PENSUB_1911	Uncharacterized protein. (84 aa)
	PENSUB_1841	Carnitinyl-CoA dehydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (275 aa)
	PENSUB_2146	Uncharacterized protein. (167 aa)
	PENSUB_2486	Carboxyvinyl-carboxyphosphonate phosphorylmutase. (480 aa)
	PENSUB_2619	3-oxoadipate enol-lactonase 2. (553 aa)
	PENSUB_2802	Uncharacterized protein. (442 aa)
	PENSUB_2718	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (292 aa)
	PENSUB_2200	Uncharacterized protein. (689 aa)
	PENSUB_4305	Acyl-coenzyme A oxidase 2, peroxisomal. (587 aa)
	PENSUB_5868	Epimerase domain-containing protein. (75 aa)
	PENSUB_5866	Uncharacterized protein. (248 aa)
	PENSUB_5869	Uncharacterized protein. (144 aa)
	PENSUB_11503	S-(Hydroxymethyl)glutathione dehydrogenase. (356 aa)
	PENSUB_14060	Uncharacterized protein. (191 aa)
	PENSUB_102	Enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (289 aa)
	PENSUB_160	Ribosomal lysine N-methyltransferase set10. (656 aa)
	PENSUB_164	Acetyl-coenzyme A synthetase. (666 aa)
	PENSUB_462	Uncharacterized protein. (162 aa)
	PENSUB_885	Epimerase domain-containing protein. (265 aa)
	PENSUB_884	Epimerase domain-containing protein. (87 aa)
	PENSUB_828	Uncharacterized protein. (272 aa)
	PENSUB_697	2-methylcitrate dehydratase, mitochondrial. (503 aa)
	PENSUB_655	Epimerase domain-containing protein. (337 aa)
	PENSUB_656	Tetraketide alpha-pyrone reductase 2. (347 aa)
	PENSUB_1109	2-methylcitrate dehydratase. (489 aa)
	PENSUB_1525	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (478 aa)

Your Current Organism:

Penicillium subrubescens

NCBI taxonomy Id: 1316194
Other names: CBS 132785, CBS H-21029, DTO 188-D6, IBT 31985, P. subrubescens

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PENSUB_10017	PENSUB_11343	A0A1Q5TAH6	A0A1Q5T3X1	Dihydrolipoyl dehydrogenase.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.593
PENSUB_10017	PENSUB_13625	A0A1Q5TAH6	A0A1Q5SNH4	Dihydrolipoyl dehydrogenase.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.593
PENSUB_10017	PENSUB_1506	A0A1Q5TAH6	A0A1Q5UJW6	Dihydrolipoyl dehydrogenase.	Peroxisomal acyl-coenzyme A oxidase 1.	0.593
PENSUB_10017	PENSUB_1525	A0A1Q5TAH6	A0A1Q5UK25	Dihydrolipoyl dehydrogenase.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.997
PENSUB_10017	PENSUB_1911	A0A1Q5TAH6	A0A1Q5UJ10	Dihydrolipoyl dehydrogenase.	Uncharacterized protein.	0.539
PENSUB_10017	PENSUB_1912	A0A1Q5TAH6	A0A1Q5UJ23	Dihydrolipoyl dehydrogenase.	Uncharacterized protein.	0.539
PENSUB_10017	PENSUB_2802	A0A1Q5TAH6	A0A1Q5UGW8	Dihydrolipoyl dehydrogenase.	Uncharacterized protein.	0.940
PENSUB_10017	PENSUB_4020	A0A1Q5TAH6	A0A1Q5UE24	Dihydrolipoyl dehydrogenase.	Uncharacterized protein.	0.635
PENSUB_10017	PENSUB_4207	A0A1Q5TAH6	A0A1Q5UD23	Dihydrolipoyl dehydrogenase.	Succinyl-CoA ligase [ADP-forming] subunit beta.	0.940
PENSUB_10017	PENSUB_4305	A0A1Q5TAH6	A0A1Q5UR61	Dihydrolipoyl dehydrogenase.	Acyl-coenzyme A oxidase 2, peroxisomal.	0.539
PENSUB_10017	PENSUB_5740	A0A1Q5TAH6	A0A1Q5U6E6	Dihydrolipoyl dehydrogenase.	L-lactate dehydrogenase A.	0.635
PENSUB_10017	PENSUB_7114	A0A1Q5TAH6	A0A1Q5TQ51	Dihydrolipoyl dehydrogenase.	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial.	0.988
PENSUB_10017	PENSUB_8195	A0A1Q5TAH6	A0A1Q5TID0	Dihydrolipoyl dehydrogenase.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.927
PENSUB_10017	PENSUB_8505	A0A1Q5TAH6	A0A1Q5TFV7	Dihydrolipoyl dehydrogenase.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.967
PENSUB_10017	PENSUB_9123	A0A1Q5TAH6	A0A1Q5TDZ1	Dihydrolipoyl dehydrogenase.	Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial.	0.800
PENSUB_10017	PENSUB_9277	A0A1Q5TAH6	A0A1Q5TD87	Dihydrolipoyl dehydrogenase.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.985
PENSUB_102	PENSUB_11343	A0A1Q5UNZ3	A0A1Q5T3X1	Enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.782
PENSUB_102	PENSUB_11557	A0A1Q5UNZ3	A0A1Q5T228	Enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family.	Acetyl-CoA acetyltransferase IB; Belongs to the thiolase-like superfamily. Thiolase family.	0.844
PENSUB_102	PENSUB_12720	A0A1Q5UNZ3	A0A1Q5SY01	Enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family.	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial.	0.742
PENSUB_102	PENSUB_13486	A0A1Q5UNZ3	A0A1Q5SQW7	Enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein.	0.831