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pgi pgi PU02_0022 PU02_0022 fumC fumC PU02_0182 PU02_0182 PU02_0321 PU02_0321 pgk pgk PU02_0323 PU02_0323 PU02_0324 PU02_0324 tal tal acsA acsA PU02_0363 PU02_0363 PU02_0366 PU02_0366 PU02_0367 PU02_0367 PU02_0368 PU02_0368 PU02_0369 PU02_0369 PU02_0382 PU02_0382 accA accA PU02_0422 PU02_0422 PU02_0423 PU02_0423 PU02_0424 PU02_0424 PU02_0425 PU02_0425 PU02_0426 PU02_0426 PU02_0427 PU02_0427 PU02_0430 PU02_0430 PU02_0431 PU02_0431 PU02_0432 PU02_0432 sucD sucD sucC sucC mdh mdh PU02_0482 PU02_0482 accD accD PU02_0539 PU02_0539 PU02_0556 PU02_0556 PU02_0562 PU02_0562 PU02_0563 PU02_0563 PU02_0564 PU02_0564 PU02_0565 PU02_0565 PU02_0566 PU02_0566 PU02_0567 PU02_0567 PU02_0568 PU02_0568 PU02_0600 PU02_0600 gpmA gpmA prs prs PU02_0904 PU02_0904 PU02_0905 PU02_0905 PU02_0931 PU02_0931 mfd mfd PU02_0988 PU02_0988 lolD lolD PU02_0990 PU02_0990 PU02_0992 PU02_0992 PU02_0993 PU02_0993 nuoN nuoN PU02_0995 PU02_0995 PU02_0996 PU02_0996 nuoK nuoK PU02_0998 PU02_0998 nuoI nuoI nuoH nuoH PU02_1001 PU02_1001 PU02_1002 PU02_1002 PU02_1003 PU02_1003 nuoD nuoD PU02_1005 PU02_1005 nuoC nuoC nuoB nuoB nuoA nuoA PU02_1024 PU02_1024 PU02_1025 PU02_1025 fabH fabH ctaA ctaA PU02_1050 PU02_1050 PU02_1051 PU02_1051 PU02_1052 PU02_1052 PU02_1053 PU02_1053 PU02_1054 PU02_1054 rpiA rpiA gltA gltA PU02_1121 PU02_1121 PU02_1122 PU02_1122 PU02_1123 PU02_1123 pdhA pdhA eno eno tpiA tpiA PU02_1159 PU02_1159 acpP acpP PU02_1161 PU02_1161 PU02_1162 PU02_1162 PU02_1229 PU02_1229 PU02_1235 PU02_1235 ctaB ctaB PU02_1250 PU02_1250
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (552 aa)
PU02_0022Aldehyde dehydrogenase. (476 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa)
PU02_0182Phosphoglucomutase. (542 aa)
PU02_0321Fructose-bisphosphate aldolase class I. (341 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (395 aa)
PU02_0323NAD-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
PU02_0324Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (668 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa)
PU02_0363Outer membrane lipoprotein carrier protein LolA; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (210 aa)
PU02_0366Succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa)
PU02_0367Succinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (614 aa)
PU02_0368Succinate dehydrogenase hydrophobic membrane anchor protein. (128 aa)
PU02_0369Succinate dehydrogenase cytochrome b-556 subunit. (133 aa)
PU02_0382Cytochrome oxidase biogenesis protein Surf1, facilitates heme A insertion. (257 aa)
accAAcetyl-coenzyme A carboxyl transferase alpha chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (318 aa)
PU02_0422Na(+) H(+) antiporter subunit G. (130 aa)
PU02_0423Na(+) H(+) antiporter subunit F. (55 aa)
PU02_0424Na(+) H(+) antiporter subunit E. (145 aa)
PU02_0425Na(+) H(+) antiporter subunit D. (539 aa)
PU02_0426Na(+) H(+) antiporter subunit C. (113 aa)
PU02_0427pH adaptation potassium efflux system a. (972 aa)
PU02_0430Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase. (468 aa)
PU02_0431Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (400 aa)
PU02_04322-oxoglutarate dehydrogenase E1 component. (1001 aa)
sucDSuccinyl-CoA ligase [ADP-forming] alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
sucCSuccinyl-CoA ligase [ADP-forming] beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (398 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
PU02_0482NADH-ubiquinone oxidoreductase 39 kD subunit. (332 aa)
accDAcetyl-coenzyme A carboxyl transferase beta chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (303 aa)
PU02_0539NADP-dependent malic enzyme. (441 aa)
PU02_0556Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (895 aa)
PU02_0562Cytochrome O ubiquinol oxidase subunit II. (322 aa)
PU02_0563Cytochrome O ubiquinol oxidase subunit I; Belongs to the heme-copper respiratory oxidase family. (672 aa)
PU02_0564Cytochrome O ubiquinol oxidase subunit III. (221 aa)
PU02_0565Cytochrome O ubiquinol oxidase subunit IV. (128 aa)
PU02_0566Enoyl-[acyl-carrier-protein] reductase [NADH]. (272 aa)
PU02_05673-oxoacyl-[acyl-carrier-protein] synthase, KASI; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (406 aa)
PU02_05683-hydroxydecanoyl-[acyl-carrier-protein] dehydratase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (169 aa)
PU02_0600Membrane c-type cytochrome cy. (147 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (244 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa)
PU02_0904Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (400 aa)
PU02_0905Fructose-1,6-bisphosphatase, GlpX type. (329 aa)
PU02_0931Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (224 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1163 aa)
PU02_0988YgfY. (96 aa)
lolDLipoprotein releasing system ATP-binding protein LolD; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. (226 aa)
PU02_0990Lipoprotein releasing system transmembrane protein LolC. (422 aa)
PU02_0992Metallo-beta-lactamase family protein, RNA-specific. (558 aa)
PU02_0993Biotin-protein ligase. (267 aa)
nuoNNADH-ubiquinone oxidoreductase chain N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (486 aa)
PU02_0995NADH-ubiquinone oxidoreductase chain M. (489 aa)
PU02_0996NADH-ubiquinone oxidoreductase chain L. (654 aa)
nuoKNADH-ubiquinone oxidoreductase chain K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (102 aa)
PU02_0998NADH-ubiquinone oxidoreductase chain J; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (206 aa)
nuoINADH-ubiquinone oxidoreductase chain I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (163 aa)
nuoHNADH-ubiquinone oxidoreductase chain H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (348 aa)
PU02_1001NADH-ubiquinone oxidoreductase chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (689 aa)
PU02_1002NADH-ubiquinone oxidoreductase chain F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (435 aa)
PU02_1003NADH-ubiquinone oxidoreductase chain E. (223 aa)
nuoDNADH-ubiquinone oxidoreductase chain D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family. (371 aa)
PU02_1005Hypothetical protein. (55 aa)
nuoCNADH-ubiquinone oxidoreductase chain C; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 30 kDa subunit family. (203 aa)
nuoBNADH-ubiquinone oxidoreductase chain B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (193 aa)
nuoANADH ubiquinone oxidoreductase chain A; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. (118 aa)
PU02_1024Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (162 aa)
PU02_1025Biotin carboxylase of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (457 aa)
fabH3-oxoacyl-[acyl-carrier-protein] synthase, KASIII; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (324 aa)
ctaAHeme A synthase, cytochrome oxidase biogenesis protein Cox15-CtaA; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. (348 aa)
PU02_1050NADP-dependent malic enzyme. (784 aa)
PU02_1051Acyl carrier protein. (94 aa)
PU02_10523-oxoacyl-[acyl-carrier-protein] synthase, KASII; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (391 aa)
PU02_10533-oxoacyl-[acyl-carrier-protein] synthase, KASII; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (434 aa)
PU02_1054Alcohol dehydrogenase. (342 aa)
rpiARibose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (234 aa)
gltACitrate synthase (si); Belongs to the citrate synthase family. (434 aa)
PU02_1121Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. (494 aa)
PU02_1122Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (437 aa)
PU02_1123Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (454 aa)
pdhAPyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (350 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (420 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa)
PU02_11593-oxoacyl-[acyl-carrier-protein] synthase, KASII; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (420 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa)
PU02_11613-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa)
PU02_1162Malonyl CoA-acyl carrier protein transacylase. (314 aa)
PU02_1229Pyruvate,phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (890 aa)
PU02_1235Mitochondrial processing peptidase-like protein; Belongs to the peptidase M16 family. (440 aa)
ctaBHeme O synthase, protoheme IX farnesyltransferase COX10-CtaB; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (291 aa)
PU02_1250Enoyl-[acyl-carrier-protein] reductase [NADH]. (272 aa)
Your Current Organism:
Bartonella ancashensis
NCBI taxonomy Id: 1318743
Other names: ATCC BAA-2694, B. ancashensis, Bartonella ancashensis Mullins et al. 2015, Bartonella sp. 20.60, Candidatus Bartonella ancashi, DSM 29364, strain 20-00, strain 20.00
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