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leuA leuA leuC leuC leuD leuD leuB leuB BN4_10123 BN4_10123 ilvE ilvE ilvB ilvB ilvH ilvH ilvC ilvC ilvB-2 ilvB-2 ilvN ilvN BN4_10485 BN4_10485 ilvD ilvD BN4_12300 BN4_12300
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (511 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (355 aa)
BN4_10123Aminotransferase class IV. (313 aa)
ilvEPutative branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa)
ilvBAcetolactate synthase large subunit. (563 aa)
ilvHAcetolactate synthase small subunit. (165 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa)
ilvB-2Acetolactate synthase isozyme 1 large subunit. (558 aa)
ilvNAcetolactate synthase isozyme 1 small subunit. (92 aa)
BN4_10485Uncharacterized AIPM/Hcit synthase family transferase aq_356; Belongs to the alpha-IPM synthase/homocitrate synthase family. (531 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (553 aa)
BN4_12300Acetolactate synthase, small subunit. (159 aa)
Your Current Organism:
Pseudodesulfovibrio piezophilus
NCBI taxonomy Id: 1322246
Other names: Desulfovibrio piezophilus C1TLV30, Desulfovibrio piezophilus DSM 21447, Desulfovibrio piezophilus JCM 15486, Desulfovibrio sp. C1TLV30, P. piezophilus C1TLV30, Pseudodesulfovibrio piezophilus C1TLV30, Pseudodesulfovibrio piezophilus DSM 21447, Pseudodesulfovibrio piezophilus JCM 15486
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