STRINGSTRING
tpiA tpiA rpe rpe BN4_20389 BN4_20389 coaE coaE hisA hisA BN4_12681 BN4_12681 BN4_12660 BN4_12660 groL-2 groL-2 ppiB ppiB BN4_12549 BN4_12549 rpiB rpiB algC algC BN4_12446 BN4_12446 murI murI queA queA gyrB gyrB gyrA gyrA cyp cyp BN4_12126 BN4_12126 purE purE BN4_12078 BN4_12078 BN4_12057 BN4_12057 exoB exoB topA topA dapF dapF BN4_11955 BN4_11955 BN4_11922 BN4_11922 BN4_11852 BN4_11852 truA truA BN4_11733 BN4_11733 hemL hemL hldD hldD alr alr BN4_11558 BN4_11558 rluA rluA Galm Galm BN4_11516 BN4_11516 trpF trpF pheA pheA gmhA gmhA BN4_11354 BN4_11354 BN4_11096 BN4_11096 groL groL celB celB BN4_11005 BN4_11005 ppi ppi BN4_10898 BN4_10898 glmM glmM truB truB mtnA mtnA ppiA ppiA rfbC rfbC algA algA cbiC cbiC nnrE nnrE BN4_10474 BN4_10474 BN4_10472 BN4_10472 BN4_10440 BN4_10440 gpmI gpmI trxA trxA tig tig BN4_10286 BN4_10286 apgM apgM gpmA gpmA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (257 aa)
rpeRibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (216 aa)
BN4_20389Phosphonopyruvate decarboxylase-related protein. (457 aa)
coaEPseudouridine synthase, RluA family; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (558 aa)
hisA1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. (242 aa)
BN4_12681UDP-N-acetylglucosamine 2-epimerase. (384 aa)
BN4_12660Pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (298 aa)
groL-260 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (529 aa)
ppiBPeptidyl-prolyl cis-trans isomerase B; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (165 aa)
BN4_12549Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen. (170 aa)
rpiBPutative ribose-5-phosphate isomerase B; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (146 aa)
algCPhosphomannomutase/phosphoglucomutase. (459 aa)
BN4_12446Homologs of previously reported genes of unknown function. (223 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (279 aa)
queAS-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (372 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (799 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (815 aa)
cypPeptidyl-prolyl cis-trans isomerase cyp18. (226 aa)
BN4_12126Phosphoglycerate mutase. (198 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (160 aa)
BN4_12078dTDP-4-dehydrorhamnose 3,5-epimerase and related enzyme. (155 aa)
BN4_12057Phosphoheptose isomerase (modular protein). (235 aa)
exoBUDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (323 aa)
topADNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (805 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (285 aa)
BN4_11955Homologs of previously reported genes of unknown function. (197 aa)
BN4_11922Glucose-6-phosphate isomerase. (446 aa)
BN4_11852PpiC-type peptidyl-prolyl cis-trans isomerase. (630 aa)
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (250 aa)
BN4_11733Putative enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the 4-oxalocrotonate tautomerase family. (69 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase. (419 aa)
hldDADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (326 aa)
alrAlanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (375 aa)
BN4_11558Homologs of previously reported genes of unknown function. (274 aa)
rluARibosomal large subunit pseudouridine synthase A. (215 aa)
GalmAldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (350 aa)
BN4_11516Glutamine--fructose-6-phosphate transaminase (Isomerizing). (941 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (207 aa)
pheAP-protein [Includes: Chorismate mutase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (405 aa)
gmhAPhosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (206 aa)
BN4_11354Homologs of previously reported genes of unknown function; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (435 aa)
BN4_11096Putative tautomerase K2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the 4-oxalocrotonate tautomerase family. (72 aa)
groL60 kDa chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (550 aa)
celBPhosphoglucomutase. (550 aa)
BN4_11005Peptidyl-prolyl cis-trans isomerase. (142 aa)
ppiPutative peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (182 aa)
BN4_10898Uncharacterized phosphosugar isomerase aq_1546; Belongs to the SIS family. GutQ/KpsF subfamily. (338 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (450 aa)
truBtRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (313 aa)
mtnAMethylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (347 aa)
ppiAPeptidyl-prolyl cis-trans isomerase A; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (168 aa)
rfbCdTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (190 aa)
algAAlginate biosynthesis protein AlgA [Includes: Mannose-6-phosphate isomerase; Mannose-1-phosphate guanylyltransferase]; Belongs to the mannose-6-phosphate isomerase type 2 family. (476 aa)
cbiCCobalt-precorrin-8X methylmutase. (212 aa)
nnrECarbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] (516 aa)
BN4_10474Homologs of previously reported genes of unknown function. (331 aa)
BN4_10472SurA domain protein. (312 aa)
BN4_10440Putative enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the pseudouridine synthase RsuA family. (250 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (509 aa)
trxAThioredoxin-1; Belongs to the thioredoxin family. (106 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (495 aa)
BN4_10286Pseudouridine synthase; Belongs to the pseudouridine synthase RluA family. (276 aa)
apgM2,3-bisphosphoglycerate-independent phosphoglycerate mutase. (398 aa)
gpmA2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (248 aa)
Your Current Organism:
Pseudodesulfovibrio piezophilus
NCBI taxonomy Id: 1322246
Other names: Desulfovibrio piezophilus C1TLV30, Desulfovibrio piezophilus DSM 21447, Desulfovibrio piezophilus JCM 15486, Desulfovibrio sp. C1TLV30, P. piezophilus C1TLV30, Pseudodesulfovibrio piezophilus C1TLV30, Pseudodesulfovibrio piezophilus DSM 21447, Pseudodesulfovibrio piezophilus JCM 15486
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.