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| | thrS | Threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (645 aa) |
| | BN4_20529 | Homologs of previously reported genes of unknown function. (175 aa) |
| | BN4_20517 | Radical SAM domain protein. (397 aa) |
| | BN4_20515 | Radical SAM domain protein. (400 aa) |
| | BN4_20509 | Aldehyde Dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1005 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (374 aa) |
| | BN4_20422 | Ferredoxin. (514 aa) |
| | lipA-2 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (225 aa) |
| | BN4_20396 | Alpha/beta hydrolase fold protein. (333 aa) |
| | BN4_20389 | Phosphonopyruvate decarboxylase-related protein. (457 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. (242 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (195 aa) |
| | guaA | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. (514 aa) |
| | acoB | Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit beta. (323 aa) |
| | acoA | Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha. (319 aa) |
| | pdhC | PdhC. (450 aa) |
| | bdhA | (R,R)-butanediol dehydrogenase. (358 aa) |
| | BN4_20345 | Homologs of previously reported genes of unknown function. (260 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (286 aa) |
| | BN4_20341 | Alginate o-acetyltransferase algI; Belongs to the membrane-bound acyltransferase family. (465 aa) |
| | BN4_20329 | Homologs of previously reported genes of unknown function. (716 aa) |
| | BN4_20328 | Homologs of previously reported genes of unknown function. (208 aa) |
| | glcD | Glycolate oxidase subunit glcD. (464 aa) |
| | aspA | Aspartate ammonia-lyase. (485 aa) |
| | BN4_20301 | GCN5-related N-acetyltransferase. (159 aa) |
| | pheT | Phenylalanyl-tRNA synthetase beta chain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (804 aa) |
| | pheS | Phenylalanyl-tRNA synthetase alpha chain; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (350 aa) |
| | BN4_20253 | FolC bifunctional protein. (392 aa) |
| | csaA | Protein CsaA. (111 aa) |
| | CooK | Carbon monoxide-induced hydrogenase, subunit CooK; Function of strongly homologous gene; enzyme. (316 aa) |
| | gabT | Putative 4-aminobutyrate aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (434 aa) |
| | ykgF | Putative oxidoreductase subunit with NAD(P)-binding domain and ferridoxin-like domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (482 aa) |
| | BN4_20090 | Putative Lactate utilization protein C; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (246 aa) |
| | BN4_20088 | Pyruvate phosphate dikinase PEP/pyruvate-binding. (820 aa) |
| | BN4_20067 | Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (365 aa) |
| | BN4_20035 | Succinylglutamate desuccinylase/aspartoacylase. (342 aa) |
| | BN4_20032 | Glutamine amidotransferase class-I. (234 aa) |
| | BN4_20024 | Pyruvate, water dikinase. (863 aa) |
| | BN4_20016 | FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (409 aa) |
| | BN4_12825 | FMN-dependent alpha-hydroxy acid dehydrogenase. (340 aa) |
| | leuS | Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (833 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (351 aa) |
| | BN4_12754 | Alcohol dehydrogenase zinc-binding domain protein. (331 aa) |
| | glnS | Glutaminyl-tRNA synthetase. (591 aa) |
| | BN4_12742 | Ketose-bisphosphate aldolase class-II. (422 aa) |
| | alaS | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (883 aa) |
| | BN4_12724 | Radical SAM domain protein. (432 aa) |
| | BN4_12715 | Homologs of previously reported genes of unknown function. (333 aa) |
| | BN4_12694 | Alginate o-acetyltransferase algI; Belongs to the membrane-bound acyltransferase family. (465 aa) |
| | BN4_12690 | Asparagine synthase (Glutamine-hydrolyzing). (623 aa) |
| | BN4_12683 | Putative D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa) |
| | cobB-2 | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (467 aa) |
| | BN4_12603 | Dimethylargininase. (252 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (154 aa) |
| | Acsm | Acyl-coenzyme A synthetase ACSM4, mitochondrial; Function of strongly homologous gene; putative enzyme. (545 aa) |
| | tyrS | Tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (427 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (292 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (124 aa) |
| | BN4_12550 | Putative enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the acetyltransferase family. (152 aa) |
| | BN4_12548 | Glutamine amidotransferase class-I. (240 aa) |
| | BN4_12515 | Homocysteine S-methyltransferase. (803 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (303 aa) |
| | serB | Phosphoserine phosphatase. (402 aa) |
| | ald | Alanine dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the AlaDH/PNT family. (367 aa) |
| | glcB | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (723 aa) |
| | BN4_12403 | SlyX family protein. (69 aa) |
| | BN4_12401 | Cyclase family protein. (211 aa) |
| | acsA-2 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa) |
| | BN4_12375 | Putative Asparaginase/glutaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (334 aa) |
| | BN4_12371 | Beta-lactamase domain protein. (278 aa) |
| | aroA-4 | Uncharacterized aldolase aq_1554; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (267 aa) |
| | BN4_12300 | Acetolactate synthase, small subunit. (159 aa) |
| | fumC | Fumarate hydratase class II 2; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa) |
| | BN4_12251 | Predicted Fe-S oxidoreductases. (289 aa) |
| | BN4_12231 | Putative Phenylacetate-coenzyme A ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (421 aa) |
| | PFK-2 | 6-phosphofructokinase 3; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (440 aa) |
| | coaBC | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (408 aa) |
| | BN4_12199 | Homologs of previously reported genes of unknown function. (389 aa) |
| | BN4_12189 | Asparagine synthase (Glutamine-hydrolyzing). (676 aa) |
| | hit | Protein hit. (141 aa) |
| | BN4_12166 | Homologs of previously reported genes of unknown function. (320 aa) |
| | fabD | malonyl-CoA-[acyl-carrier-protein] transacylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (308 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | fabI | Enoyl-[acyl-carrier-protein] reductase [NADH] 1; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (254 aa) |
| | BN4_12143 | Homologs of previously reported genes of unknown function. (387 aa) |
| | BN4_12129 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (290 aa) |
| | BN4_12126 | Phosphoglycerate mutase. (198 aa) |
| | BN4_12120 | Aminotransferase class IV. (256 aa) |
| | BN4_12103 | Homologs of previously reported genes of unknown function. (69 aa) |
| | BN4_12083 | Putative Predicted Fe-S oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (312 aa) |
| | BN4_12067 | Putative amidotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (644 aa) |
| | BN4_12065 | Putative Radical SAM domain protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (359 aa) |
| | BN4_12061 | UDP-glucose/GDP-mannose dehydrogenase. (415 aa) |
| | acsA | Acetyl-coenzyme A synthetase. (667 aa) |
| | glnA-2 | Glutamine synthetase. (447 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (285 aa) |
| | BN4_11987 | Glutamate synthase (NADPH), homotetrameric. (472 aa) |
| | pyrB | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (309 aa) |
| | aspS | Aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (609 aa) |
| | hisS | Histidyl-tRNA synthetase. (413 aa) |
| | selD | Selenide, water dikinase. (299 aa) |
| | rocD | Ornithine aminotransferase; Catalyzes the interconversion of ornithine to glutamate semialdehyde. (399 aa) |
| | BN4_11964 | Homologs of previously reported genes of unknown function. (439 aa) |
| | vdlD | Protein vdlD. (166 aa) |
| | cobB | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (467 aa) |
| | valS | Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (888 aa) |
| | BN4_11930 | Proline dehydrogenase. (315 aa) |
| | BN4_11922 | Glucose-6-phosphate isomerase. (446 aa) |
| | PFK | 6-phosphofructokinase 6. (446 aa) |
| | BN4_11881 | Homologs of previously reported genes of unknown function. (387 aa) |
| | BN4_11878 | Putative Fe-S oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (748 aa) |
| | BN4_11873 | Related to coenzyme F390 synthetase. (436 aa) |
| | BN4_11870 | Phosphoglycerate mutase. (201 aa) |
| | BN4_11863 | Putative Hydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (351 aa) |
| | BN4_11862 | 4Fe-4S ferredoxin iron-sulfur binding domain protein. (317 aa) |
| | hdrB | Heterodisulfide reductase subunit B; Function of strongly homologous gene; enzyme. (298 aa) |
| | BN4_11849 | EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase). (634 aa) |
| | ispDF | Bifunctional enzyme ispD/ispF [Includes: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). (398 aa) |
| | cysS | Cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (485 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa) |
| | folD | Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa) |
| | BN4_11815 | Radical SAM domain protein. (369 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa) |
| | argS | Arginyl-tRNA synthetase. (571 aa) |
| | metX | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (396 aa) |
| | yqeC | Putative 6-phosphogluconate dehydrogenase YqeC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (302 aa) |
| | BN4_11746 | Oxidoreductase, FAD/iron-sulfur cluster-binding domain protein. (940 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ [Includes: Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (393 aa) |
| | BN4_11723 | Malate dehydrogenase (Oxaloacetate-decarboxylating) (NADP(+)). (439 aa) |
| | BN4_11704 | Aminoglycoside phosphotransferase. (313 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (332 aa) |
| | BN4_11683 | FAD linked oxidase domain protein. (481 aa) |
| | mqnB | Purine or other phosphorylase family 1; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (232 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (375 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (553 aa) |
| | cobDQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (895 aa) |
| | gltX | Glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (465 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (352 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (330 aa) |
| | fabG-2 | 3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (77 aa) |
| | fabF | 3-oxoacyl-[acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (412 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | pyk | Pyruvate kinase 1; Function of strongly homologous gene; enzyme; Belongs to the pyruvate kinase family. (480 aa) |
| | BN4_11516 | Glutamine--fructose-6-phosphate transaminase (Isomerizing). (941 aa) |
| | EchB | Ech hydrogenase, subunit EchB; Function experimentally demonstrated in the studied genus; enzyme. (282 aa) |
| | proS | Prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (581 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (356 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (282 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (253 aa) |
| | trpB | Tryptophan synthase beta chain 1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (387 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (207 aa) |
| | BN4_11444 | Indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (256 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (335 aa) |
| | tyrA | Prephenate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (257 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (446 aa) |
| | pheA | P-protein [Includes: Chorismate mutase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (405 aa) |
| | BN4_11437 | 3-dehydroquinate synthase homolog. (327 aa) |
| | aroA-3 | Uncharacterized aldolase aq_1554; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (265 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (128 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa) |
| | BN4_11418 | Homologs of previously reported genes of unknown function. (217 aa) |
| | icd | Isocitrate dehydrogenase [NADP]. (380 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (756 aa) |
| | BN4_11366 | Homologs of previously reported genes of unknown function. (260 aa) |
| | BN4_11365 | Homologs of previously reported genes of unknown function. (381 aa) |
| | BN4_11363 | Homologs of previously reported genes of unknown function. (407 aa) |
| | nahM | Putative 4-hydroxy-2-oxovalerate aldolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (334 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (310 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (386 aa) |
| | FATA | Acyl-ACP thioesterase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (268 aa) |
| | cysK-2 | Cysteine synthase. (318 aa) |
| | BN4_11210 | Protein of unknown function; No homology to any previously reported sequences. (77 aa) |
| | ygeX | 2,3-diaminopropionate ammonia-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (410 aa) |
| | BN4_11191 | Peptidase M20. (392 aa) |
| | BN4_11172 | GCN5-related N-acetyltransferase. (287 aa) |
| | kamA | L-lysine 2,3-aminomutase. (437 aa) |
| | yvgN | Glyoxal reductase. (283 aa) |
| | BN4_11099 | Homologs of previously reported genes of unknown function. (241 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (294 aa) |
| | paaK-3 | Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (429 aa) |
| | BN4_11032 | Threonine aldolase. (346 aa) |
| | BN4_11008 | Cysteine synthase. (759 aa) |
| | trpS | Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (329 aa) |
| | BN4_10996 | Threonine synthase. (377 aa) |
| | BN4_10993 | FAD linked oxidase domain protein. (1176 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (419 aa) |
| | yngI | acyl-CoA synthetase yngI; Function of strongly homologous gene; enzyme. (604 aa) |
| | BN4_10907 | Beta-lactamase domain protein. (293 aa) |
| | metG | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (651 aa) |
| | carB | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1078 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (471 aa) |
| | BN4_10887 | Predicted Fe-S oxidoreductases. (315 aa) |
| | BN4_10876 | Threonine synthase. (522 aa) |
| | paaK-2 | Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (428 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | BN4_10862 | Homologs of previously reported genes of unknown function; Belongs to the UPF0173 family. (227 aa) |
| | BN4_10854 | Glu/Leu/Phe/Val dehydrogenase. (984 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (300 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (410 aa) |
| | argH | Argininosuccinate lyase. (462 aa) |
| | BN4_10841 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (279 aa) |
| | aroL | Shikimate kinase 2; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (354 aa) |
| | gcvPB | Putative glycine dehydrogenase [decarboxylating] subunit 2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (480 aa) |
| | gcvPA | Putative glycine dehydrogenase [decarboxylating] subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (444 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa) |
| | mtnA | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (347 aa) |
| | accA-2 | Acetyl-CoA carboxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (748 aa) |
| | accC-2 | acetyl-CoA carboxylase subunit (biotin carboxylase subunit); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (472 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (412 aa) |
| | dapL | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (388 aa) |
| | BN4_10701 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase (fragment). (144 aa) |
| | BN4_10697 | Pyruvate, water dikinase. (863 aa) |
| | BN4_10686 | Agmatinase; Belongs to the arginase family. (284 aa) |
| | speA | Biosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. (637 aa) |
| | BN4_10682 | CoA-substrate-specific enzyme activase. (265 aa) |
| | BN4_10653 | CoB--CoM heterodisulfide reductase. (285 aa) |
| | BN4_10585 | Malate dehydrogenase (Oxaloacetate-decarboxylating) (NADP(+)). (440 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (547 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | BN4_10532 | Putative enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (406 aa) |
| | MTAP | S-methyl-5'-thioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (249 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (266 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (406 aa) |
| | BN4_10503 | Glutamate synthase; Belongs to the glutamate synthase family. (421 aa) |
| | BN4_10502 | Homologs of previously reported genes of unknown function. (365 aa) |
| | BN4_10501 | Homologs of previously reported genes of unknown function. (253 aa) |
| | eutC | Ethanolamine ammonia-lyase light chain; Function of strongly homologous gene; enzyme; Belongs to the EutC family. (271 aa) |
| | eutB | Ethanolamine ammonia-lyase heavy chain; Function of strongly homologous gene; enzyme. (496 aa) |
| | BN4_10485 | Uncharacterized AIPM/Hcit synthase family transferase aq_356; Belongs to the alpha-IPM synthase/homocitrate synthase family. (531 aa) |
| | lysC | Aspartokinase; Belongs to the aspartokinase family. (411 aa) |
| | acpS | Holo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (123 aa) |
| | udg | UDP-glucose 6-dehydrogenase. (445 aa) |
| | glyQ | Glycyl-tRNA synthetase alpha subunit. (289 aa) |
| | glyS | Glycyl-tRNA synthetase beta subunit. (703 aa) |
| | dsvB | Sulfite reductase, assimilatory-type; Function of strongly homologous gene; enzyme; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (219 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (346 aa) |
| | bioD | Conserved protein of unknown function; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (670 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (257 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (405 aa) |
| | BN4_10443 | Aminomethyltransferase. (361 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (159 aa) |
| | BN4_10420 | Pyruvate phosphate dikinase PEP/pyruvate-binding. (1196 aa) |
| | BN4_10419 | Carbamoyl-phosphate synthase L chain ATP-binding. (1236 aa) |
| | ilvN | Acetolactate synthase isozyme 1 small subunit. (92 aa) |
| | nifS | Cysteine desulfurase; Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. (398 aa) |
| | cysK | O-acetylserine sulfhydrylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. (306 aa) |
| | srpH | Serine acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (306 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (938 aa) |
| | BN4_10385 | O-acetylhomoserine (thiol)-lyase. (436 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa) |
| | ilvH | Acetolactate synthase small subunit. (165 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (509 aa) |
| | paaK | Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (434 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (259 aa) |
| | asnS | Asparaginyl-tRNA synthetase. (455 aa) |
| | BN4_10282 | FAD dependent oxidoreductase. (399 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (213 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa) |
| | BN4_10266 | Homologs of previously reported genes of unknown function. (216 aa) |
| | accA | Acetyl-CoA carboxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (755 aa) |
| | accC | Pyruvate carboxylase/acetyl-CoA carboxylase subunit (biotin carboxylase subunit); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (472 aa) |
| | ilvE | Putative branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa) |
| | yfdZ | Putative aminotransferase, PLP-dependent; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (403 aa) |
| | hom | Homoserine dehydrogenase. (432 aa) |
| | apgM | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase. (398 aa) |
| | BN4_10227 | Glucokinase; Belongs to the bacterial glucokinase family. (316 aa) |
| | fabZ | (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (152 aa) |
| | lysS | Lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (504 aa) |
| | BN4_10123 | Aminotransferase class IV. (313 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (341 aa) |
| | BN4_10121 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (290 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (355 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (511 aa) |
| | gpmA | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (248 aa) |
| | BN4_10071 | Ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (544 aa) |
| | BN4_10070 | Glutamate synthase (NADPH). (378 aa) |
| | aroA-2 | Uncharacterized aldolase aq_1554; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (263 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (404 aa) |
