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| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (404 aa) |
| | cdsA | Phosphatidate cytidylyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CDS family. (267 aa) |
| | uppS | Undecaprenyl pyrophosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (236 aa) |
| | plsC | Phospholipid/glycerol acyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (240 aa) |
| | BN4_10022 | Fumarate reductase respiratory complex transmembrane subunit. (216 aa) |
| | frdA | Fumarate reductase flavoprotein subunit. (611 aa) |
| | frdB | Fumarate reductase iron-sulfur subunit. (246 aa) |
| | BN4_10025 | Putative fumarate hydratase subunit alpha; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (279 aa) |
| | BN4_10026 | Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit. (183 aa) |
| | lysN | 2-aminoadipate transaminase. (391 aa) |
| | aroA-2 | Uncharacterized aldolase aq_1554; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (263 aa) |
| | BN4_10071 | Ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (544 aa) |
| | rmlA | Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (296 aa) |
| | gpmA | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (248 aa) |
| | psd | Phosphatidylserine decarboxylase proenzyme; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (215 aa) |
| | pssA | CDP-diacylglycerol/serine O-phosphatidyltransferase; Function of strongly homologous gene; enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (256 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (511 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (355 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (341 aa) |
| | BN4_10123 | Aminotransferase class IV. (313 aa) |
| | BN4_10126 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (300 aa) |
| | rmlB | dTDP-glucose 4,6 dehydratase, NAD(P)-binding; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (338 aa) |
| | BN4_10227 | Glucokinase; Belongs to the bacterial glucokinase family. (316 aa) |
| | gpt | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (160 aa) |
| | apgM | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase. (398 aa) |
| | hom | Homoserine dehydrogenase. (432 aa) |
| | ilvE | Putative branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa) |
| | BN4_10251 | Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (561 aa) |
| | BN4_10252 | Pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit. (276 aa) |
| | punA | Purine nucleoside phosphorylase 1; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (279 aa) |
| | accC | Pyruvate carboxylase/acetyl-CoA carboxylase subunit (biotin carboxylase subunit); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (472 aa) |
| | accA | Acetyl-CoA carboxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (755 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (213 aa) |
| | yiaY | Fe-containing alcohol dehydrogenase; Function of strongly homologous gene; enzyme. (396 aa) |
| | fbp | Fructose-1,6-bisphosphatase class 1. (343 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (259 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (509 aa) |
| | miaA | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (314 aa) |
| | ilvB | Acetolactate synthase large subunit. (563 aa) |
| | ilvH | Acetolactate synthase small subunit. (165 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa) |
| | srpH | Serine acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (306 aa) |
| | cysK | O-acetylserine sulfhydrylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. (306 aa) |
| | ilvB-2 | Acetolactate synthase isozyme 1 large subunit. (558 aa) |
| | ilvN | Acetolactate synthase isozyme 1 small subunit. (92 aa) |
| | sucD | CoA-binding domain protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (692 aa) |
| | BN4_10420 | Pyruvate phosphate dikinase PEP/pyruvate-binding. (1196 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (159 aa) |
| | BN4_10443 | Aminomethyltransferase. (361 aa) |
| | BN4_10445 | NUDIX hydrolase. (178 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (257 aa) |
| | lysC | Aspartokinase; Belongs to the aspartokinase family. (411 aa) |
| | BN4_10485 | Uncharacterized AIPM/Hcit synthase family transferase aq_356; Belongs to the alpha-IPM synthase/homocitrate synthase family. (531 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (327 aa) |
| | surE | 5'-nucleotidase surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (250 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (406 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (266 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase 1. (271 aa) |
| | BN4_10580 | Fumarate reductase respiratory complex transmembrane subunit. (214 aa) |
| | frdA-2 | Fumarate reductase flavoprotein subunit. (626 aa) |
| | frdB-2 | Fumarate reductase iron-sulfur subunit. (246 aa) |
| | BN4_10583 | Putative fumarate hydratase subunit alpha; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (278 aa) |
| | BN4_10584 | Putative fumarate hydratase subunit beta; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (197 aa) |
| | nifJ | Pyruvate-flavodoxin oxidoreductase. (1200 aa) |
| | sdaA | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (453 aa) |
| | korC | 2-oxoglutarate synthase subunit korC. (196 aa) |
| | korB | 2-oxoglutarate synthase subunit korB. (283 aa) |
| | korA | 2-oxoglutarate synthase subunit korA. (381 aa) |
| | BN4_10605 | 4Fe-4S ferredoxin iron-sulfur binding domain protein. (89 aa) |
| | algA | Alginate biosynthesis protein AlgA [Includes: Mannose-6-phosphate isomerase; Mannose-1-phosphate guanylyltransferase]; Belongs to the mannose-6-phosphate isomerase type 2 family. (476 aa) |
| | rfbC | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (190 aa) |
| | glpB | Glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Function of strongly homologous gene; membrane component. (421 aa) |
| | BN4_10656 | FAD dependent oxidoreductase. (527 aa) |
| | BN4_10684 | Saccharopine dehydrogenase. (396 aa) |
| | BN4_10697 | Pyruvate, water dikinase. (863 aa) |
| | dapL | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (388 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (412 aa) |
| | BN4_10715 | Siroheme synthase. (225 aa) |
| | hemA | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (457 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (221 aa) |
| | accA-2 | Acetyl-CoA carboxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (748 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa) |
| | gcvPA | Putative glycine dehydrogenase [decarboxylating] subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (444 aa) |
| | gcvPB | Putative glycine dehydrogenase [decarboxylating] subunit 2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (480 aa) |
| | BN4_10787 | Dihydrolipoyl dehydrogenase. (454 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (354 aa) |
| | aroL | Shikimate kinase 2; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa) |
| | gtaB | UTP--glucose-1-phosphate uridylyltransferase. (290 aa) |
| | argH | Argininosuccinate lyase. (462 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (410 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (300 aa) |
| | BN4_10858 | UbiD family decarboxylase; Belongs to the UbiD family. (614 aa) |
| | ubiX | Putative aromatic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (188 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (298 aa) |
| | BN4_10876 | Threonine synthase. (522 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (471 aa) |
| | gyaR | Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (326 aa) |
| | Glyctk | Glycerate kinase; Function of strongly homologous gene; putative enzyme. (447 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (419 aa) |
| | BN4_10996 | Threonine synthase. (377 aa) |
| | BN4_11008 | Cysteine synthase. (759 aa) |
| | celB | Phosphoglucomutase. (550 aa) |
| | BN4_11016 | Ste24 endopeptidase. (412 aa) |
| | BN4_11032 | Threonine aldolase. (346 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (294 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (312 aa) |
| | BN4_11083 | Riboflavin biosynthesis protein RibF; Belongs to the ribF family. (330 aa) |
| | cysK-2 | Cysteine synthase. (318 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (386 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (310 aa) |
| | BN4_11354 | Homologs of previously reported genes of unknown function; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (435 aa) |
| | fabG | 3-oxoacyl-[acyl-carrier-protein] reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (242 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (756 aa) |
| | icd | Isocitrate dehydrogenase [NADP]. (380 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (128 aa) |
| | metK | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (389 aa) |
| | aroA-3 | Uncharacterized aldolase aq_1554; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (265 aa) |
| | BN4_11437 | 3-dehydroquinate synthase homolog. (327 aa) |
| | pheA | P-protein [Includes: Chorismate mutase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (405 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (446 aa) |
| | tyrA | Prephenate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (257 aa) |
| | trpE | Anthranilate synthase component 1. (485 aa) |
| | trpG | Anthranilate synthase component II. (196 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (335 aa) |
| | BN4_11444 | Indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (256 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (207 aa) |
| | trpB | Tryptophan synthase beta chain 1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (387 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (253 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (282 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (356 aa) |
| | BN4_11490 | Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (299 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (642 aa) |
| | purB | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa) |
| | Galm | Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (350 aa) |
| | ppnP | Conserved protein of unknown function; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (104 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase. (353 aa) |
| | pyk | Pyruvate kinase 1; Function of strongly homologous gene; enzyme; Belongs to the pyruvate kinase family. (480 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (77 aa) |
| | fabG-2 | 3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (352 aa) |
| | gltX | Glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (465 aa) |
| | BN4_11631 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (366 aa) |
| | ribE | Riboflavin synthase alpha chain. (218 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (553 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (998 aa) |
| | BN4_11671 | Trans-hexaprenyltranstransferase; Belongs to the FPP/GGPP synthase family. (322 aa) |
| | mqnB | Purine or other phosphorylase family 1; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (232 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (292 aa) |
| | BN4_11682 | Homologs of previously reported genes of unknown function. (394 aa) |
| | BN4_11683 | FAD linked oxidase domain protein. (481 aa) |
| | tal | Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase [NAD(P)+]; Function of strongly homologous gene; enzyme; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (330 aa) |
| | hemL | Glutamate-1-semialdehyde 2,1-aminomutase. (419 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ [Includes: Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (393 aa) |
| | yqeC | Putative 6-phosphogluconate dehydrogenase YqeC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (302 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (494 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (251 aa) |
| | BN4_11775 | NmrA family protein. (287 aa) |
| | metX | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (396 aa) |
| | BN4_11780 | 4-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. (287 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa) |
| | sat | Sulfate adenylyltransferase (ATP-sulfurylase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (427 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa) |
| | ispDF | Bifunctional enzyme ispD/ispF [Includes: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). (398 aa) |
| | BN4_11851 | Aconitate hydratase. (640 aa) |
| | yiaY-3 | Fe-containing alcohol dehydrogenase; Function of strongly homologous gene; enzyme. (380 aa) |
| | yiaY-4 | Fe-containing alcohol dehydrogenase; Function of strongly homologous gene; enzyme. (393 aa) |
| | PFK | 6-phosphofructokinase 6. (446 aa) |
| | BN4_11894 | Putative Protoheme IX farnesyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (275 aa) |
| | BN4_11922 | Glucose-6-phosphate isomerase. (446 aa) |
| | BN4_11930 | Proline dehydrogenase. (315 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (234 aa) |
| | BN4_11935 | Uroporphyrin-III C-methyltransferase. (501 aa) |
| | rocD | Ornithine aminotransferase; Catalyzes the interconversion of ornithine to glutamate semialdehyde. (399 aa) |
| | BN4_11982 | S-adenosylhomocysteine deaminase. (376 aa) |
| | BN4_11987 | Glutamate synthase (NADPH), homotetrameric. (472 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (285 aa) |
| | acsA | Acetyl-coenzyme A synthetase. (667 aa) |
| | BN4_12059 | GDP-mannose 3,5-epimerase. (324 aa) |
| | BN4_12067 | Putative amidotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (644 aa) |
| | BN4_12073 | Radical SAM domain protein (fragment). (514 aa) |
| | BN4_12078 | dTDP-4-dehydrorhamnose 3,5-epimerase and related enzyme. (155 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (425 aa) |
| | purE | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (160 aa) |
| | fabI | Enoyl-[acyl-carrier-protein] reductase [NADH] 1; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (254 aa) |
| | BN4_12153 | HAD-superfamily hydrolase, subfamily IA, variant 3. (223 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | fabD | malonyl-CoA-[acyl-carrier-protein] transacylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (308 aa) |
| | BN4_12189 | Asparagine synthase (Glutamine-hydrolyzing). (676 aa) |
| | BN4_12202 | Pyruvate ferredoxin/flavodoxin oxidoreductase. (180 aa) |
| | BN4_12203 | Thiamine pyrophosphate protein domain protein TPP-binding. (256 aa) |
| | vorB | Ketoisovalerate oxidoreductase subunit vorB. (356 aa) |
| | BN4_12205 | 4Fe-4S ferredoxin iron-sulfur binding domain protein. (77 aa) |
| | PFK-2 | 6-phosphofructokinase 3; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (440 aa) |
| | fumC | Fumarate hydratase class II 2; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa) |
| | BN4_12300 | Acetolactate synthase, small subunit. (159 aa) |
| | yiaY-5 | Fe-containing alcohol dehydrogenase; Function of strongly homologous gene; enzyme. (389 aa) |
| | aroA-4 | Uncharacterized aldolase aq_1554; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (267 aa) |
| | BN4_12375 | Putative Asparaginase/glutaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (334 aa) |
| | acsA-2 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa) |
| | BN4_12410 | Putative fructokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (294 aa) |
| | glcB | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (723 aa) |
| | serB | Phosphoserine phosphatase. (402 aa) |
| | algC | Phosphomannomutase/phosphoglucomutase. (459 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (303 aa) |
| | yggF | Putative hexoseP phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (329 aa) |
| | tkt | Transketolase; Belongs to the transketolase family. (654 aa) |
| | rpiB | Putative ribose-5-phosphate isomerase B; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (146 aa) |
| | BN4_12515 | Homocysteine S-methyltransferase. (803 aa) |
| | aatA | Aspartate aminotransferase A. (390 aa) |
| | BN4_12550 | Putative enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the acetyltransferase family. (152 aa) |
| | hpt | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (175 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (124 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (292 aa) |
| | Acsm | Acyl-coenzyme A synthetase ACSM4, mitochondrial; Function of strongly homologous gene; putative enzyme. (545 aa) |
| | otsA | Trehalose-phosphate synthase. (490 aa) |
| | BN4_12683 | Putative D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa) |
| | BN4_12690 | Asparagine synthase (Glutamine-hydrolyzing). (623 aa) |
| | BN4_12742 | Ketose-bisphosphate aldolase class-II. (422 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (351 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (221 aa) |
| | yhdR | Putative aspartate aminotransferase yhdR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (398 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (178 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (310 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (157 aa) |
| | ribBA | Riboflavin biosynthesis protein ribBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (403 aa) |
| | BN4_20016 | FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (409 aa) |
| | BN4_20024 | Pyruvate, water dikinase. (863 aa) |
| | kat | Catalase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the catalase family. (503 aa) |
| | BN4_20088 | Pyruvate phosphate dikinase PEP/pyruvate-binding. (820 aa) |
| | BN4_20184 | Putative alpha-amylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (399 aa) |
| | BN4_20185 | Glycosyl transferase group 1. (428 aa) |
| | gltA | Citrate synthase 1; Belongs to the citrate synthase family. (444 aa) |
| | plsY | Glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (196 aa) |
| | BN4_20295 | IMP cyclohydrolase. (424 aa) |
| | nifJ-2 | Pyruvate-flavodoxin oxidoreductase. (1196 aa) |
| | glcD | Glycolate oxidase subunit glcD. (464 aa) |
| | BN4_20325 | Homologs of previously reported genes of unknown function. (426 aa) |
| | pdhC | PdhC. (450 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (195 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. (242 aa) |
| | BN4_20389 | Phosphonopyruvate decarboxylase-related protein. (457 aa) |
| | mqnA | Conserved protein of unknown function; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (274 aa) |
| | mqnC | Radical SAM domain protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (355 aa) |
| | mqnE | Radical SAM domain protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (364 aa) |
| | mqnD | Conserved protein of unknown function; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (275 aa) |
| | BN4_20509 | Aldehyde Dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1005 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (216 aa) |
| | BN4_20515 | Radical SAM domain protein. (400 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (327 aa) |
| | BN4_20517 | Radical SAM domain protein. (397 aa) |
