(11 nodes) CoA carboxylase activity, and Pyruvate dehydrogenase complex network (Acinetobacter equi)

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	gltA	Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (424 aa)
	accA	acetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (274 aa)
	aceE	Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (900 aa)
	ALH94904.1	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (652 aa)
	acsA	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (647 aa)
	accD	acetyl-CoA carboxyl transferase; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (298 aa)
	ALH95783.1	Malonyl CoA-ACP transacylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
	ALH95912.1	acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (454 aa)
	ALH95913.1	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (139 aa)
	ALH96105.1	6-carboxyhexanoate--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (699 aa)
	ALH96429.1	acetyl/propionyl-CoA carboxylase subuit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (573 aa)

Your Current Organism:

Acinetobacter equi

NCBI taxonomy Id: 1324350
Other names: A. equi, Acinetobacter equi Poppel et al. 2016, Acinetobacter sp. 114, CCUG 65204, DSM 27228, strain 114

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALH94904.1	ALH95783.1	AOY20_04785	AOY20_09710	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Malonyl CoA-ACP transacylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.568
ALH94904.1	ALH95912.1	AOY20_04785	AOY20_10420	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	0.993
ALH94904.1	ALH95913.1	AOY20_04785	AOY20_10425	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	0.911
ALH94904.1	ALH96105.1	AOY20_04785	AOY20_11485	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	6-carboxyhexanoate--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.902
ALH94904.1	ALH96429.1	AOY20_04785	AOY20_13255	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl/propionyl-CoA carboxylase subuit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.992
ALH94904.1	accA	AOY20_04785	AOY20_01285	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.	0.967
ALH94904.1	accD	AOY20_04785	AOY20_06650	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA carboxyl transferase; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family.	0.990
ALH94904.1	aceE	AOY20_04785	AOY20_04780	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.999
ALH94904.1	acsA	AOY20_04785	AOY20_04855	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.931
ALH94904.1	gltA	AOY20_04785	AOY20_00595	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family.	0.968
ALH95783.1	ALH94904.1	AOY20_09710	AOY20_04785	Malonyl CoA-ACP transacylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.568
ALH95783.1	ALH95912.1	AOY20_09710	AOY20_10420	Malonyl CoA-ACP transacylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	0.951
ALH95783.1	ALH95913.1	AOY20_09710	AOY20_10425	Malonyl CoA-ACP transacylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	0.947
ALH95783.1	ALH96429.1	AOY20_09710	AOY20_13255	Malonyl CoA-ACP transacylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl/propionyl-CoA carboxylase subuit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.966
ALH95783.1	accA	AOY20_09710	AOY20_01285	Malonyl CoA-ACP transacylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.	0.958
ALH95783.1	accD	AOY20_09710	AOY20_06650	Malonyl CoA-ACP transacylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA carboxyl transferase; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family.	0.969
ALH95912.1	ALH94904.1	AOY20_10420	AOY20_04785	acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.993
ALH95912.1	ALH95783.1	AOY20_10420	AOY20_09710	acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	Malonyl CoA-ACP transacylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.951
ALH95912.1	ALH95913.1	AOY20_10420	AOY20_10425	acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	0.999
ALH95912.1	ALH96105.1	AOY20_10420	AOY20_11485	acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	6-carboxyhexanoate--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900