(14 nodes) Notch signaling pathway network (Rhodnius prolixus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	R4G877_RHOPR	Putative gamma-secretase subunit pen-2. (101 aa)
	T1H8I2_RHOPR	Notch binding. (1224 aa)
	T1HN85_RHOPR	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (412 aa)
	T1HVI8_RHOPR	Uncharacterized protein. (1890 aa)
	T1HWT7_RHOPR	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (979 aa)
	T1HZX0_RHOPR	Ncstrn_small domain-containing protein. (649 aa)
	T1I9M6_RHOPR	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (702 aa)
	T1ID84_RHOPR	Uncharacterized protein. (438 aa)
	T1IDA5_RHOPR	Uncharacterized protein. (503 aa)
	T1IDL4_RHOPR	Uncharacterized protein. (240 aa)
	T1IF46_RHOPR	F5/8 type C domain-containing protein. (156 aa)
	T1IF47_RHOPR	Uncharacterized protein. (259 aa)
	T1IF48_RHOPR	Uncharacterized protein. (1541 aa)
	T1IFW3_RHOPR	PID domain-containing protein. (623 aa)

Your Current Organism:

Rhodnius prolixus

NCBI taxonomy Id: 13249
Other names: R. prolixus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
R4G877_RHOPR	T1H8I2_RHOPR	R4G877	T1H8I2	Putative gamma-secretase subunit pen-2.	Notch binding.	0.424
R4G877_RHOPR	T1HN85_RHOPR	R4G877	T1HN85	Putative gamma-secretase subunit pen-2.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.991
R4G877_RHOPR	T1HVI8_RHOPR	R4G877	T1HVI8	Putative gamma-secretase subunit pen-2.	Uncharacterized protein.	0.911
R4G877_RHOPR	T1HWT7_RHOPR	R4G877	T1HWT7	Putative gamma-secretase subunit pen-2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.785
R4G877_RHOPR	T1HZX0_RHOPR	R4G877	T1HZX0	Putative gamma-secretase subunit pen-2.	Ncstrn_small domain-containing protein.	0.996
R4G877_RHOPR	T1I9M6_RHOPR	R4G877	T1I9M6	Putative gamma-secretase subunit pen-2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.424
R4G877_RHOPR	T1IDL4_RHOPR	R4G877	T1IDL4	Putative gamma-secretase subunit pen-2.	Uncharacterized protein.	0.992
R4G877_RHOPR	T1IF46_RHOPR	R4G877	T1IF46	Putative gamma-secretase subunit pen-2.	F5/8 type C domain-containing protein.	0.424
R4G877_RHOPR	T1IF47_RHOPR	R4G877	T1IF47	Putative gamma-secretase subunit pen-2.	Uncharacterized protein.	0.424
R4G877_RHOPR	T1IF48_RHOPR	R4G877	T1IF48	Putative gamma-secretase subunit pen-2.	Uncharacterized protein.	0.424
T1H8I2_RHOPR	R4G877_RHOPR	T1H8I2	R4G877	Notch binding.	Putative gamma-secretase subunit pen-2.	0.424
T1H8I2_RHOPR	T1HN85_RHOPR	T1H8I2	T1HN85	Notch binding.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.566
T1H8I2_RHOPR	T1HVI8_RHOPR	T1H8I2	T1HVI8	Notch binding.	Uncharacterized protein.	0.404
T1H8I2_RHOPR	T1HWT7_RHOPR	T1H8I2	T1HWT7	Notch binding.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.912
T1H8I2_RHOPR	T1HZX0_RHOPR	T1H8I2	T1HZX0	Notch binding.	Ncstrn_small domain-containing protein.	0.526
T1H8I2_RHOPR	T1I9M6_RHOPR	T1H8I2	T1I9M6	Notch binding.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.806
T1H8I2_RHOPR	T1ID84_RHOPR	T1H8I2	T1ID84	Notch binding.	Uncharacterized protein.	0.823
T1H8I2_RHOPR	T1IDA5_RHOPR	T1H8I2	T1IDA5	Notch binding.	Uncharacterized protein.	0.904
T1H8I2_RHOPR	T1IDL4_RHOPR	T1H8I2	T1IDL4	Notch binding.	Uncharacterized protein.	0.436
T1H8I2_RHOPR	T1IF46_RHOPR	T1H8I2	T1IF46	Notch binding.	F5/8 type C domain-containing protein.	0.900