(30 nodes) Telomere maintenance network (Rhodnius prolixus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T1I6W3_RHOPR	FAT domain-containing protein. (215 aa)
	T1HN14_RHOPR	FAT domain-containing protein. (354 aa)
	T1HNB6_RHOPR	Rad51 domain-containing protein. (107 aa)
	T1HQ83_RHOPR	Protein kinase domain-containing protein. (129 aa)
	T1HS80_RHOPR	Zinc-hook domain-containing protein. (1298 aa)
	T1HTA7_RHOPR	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (559 aa)
	T1I0U6_RHOPR	Uncharacterized protein. (344 aa)
	T1I0X0_RHOPR	Uncharacterized protein. (428 aa)
	T1I0X2_RHOPR	Uncharacterized protein. (265 aa)
	T1I2T7_RHOPR	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (3349 aa)
	T1I325_RHOPR	Ku domain-containing protein. (582 aa)
	T1I3A7_RHOPR	ATP-dependent DNA helicase (Fragment). (597 aa)
	T1I572_RHOPR	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. (513 aa)
	T1HTC0_RHOPR	NUC194 domain-containing protein. (158 aa)
	T1HZ08_RHOPR	Uncharacterized protein. (1973 aa)
	T1I0G2_RHOPR	DUF3385 domain-containing protein. (363 aa)
	T1IFJ8_RHOPR	Uncharacterized protein. (696 aa)
	T1I7Y7_RHOPR	Ku domain-containing protein. (351 aa)
	T1HLU9_RHOPR	Helicase ATP-binding domain-containing protein. (759 aa)
	R4FKD6_RHOPR	Checkpoint protein; Belongs to the HUS1 family. (276 aa)
	R4FND4_RHOPR	Putative dna repair protein rhp57. (324 aa)
	R4G4E3_RHOPR	Uncharacterized protein. (128 aa)
	R4G7S1_RHOPR	Uncharacterized protein; Belongs to the CGI121/TPRKB family. (170 aa)
	T1HA09_RHOPR	Protein kinase domain-containing protein. (640 aa)
	T1HA10_RHOPR	Uncharacterized protein. (144 aa)
	T1HB49_RHOPR	Protein kinase domain-containing protein. (107 aa)
	T1HBB2_RHOPR	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (540 aa)
	T1HDI7_RHOPR	Lactamase_B domain-containing protein. (270 aa)
	T1HDX0_RHOPR	Uncharacterized protein; Belongs to the ATP-dependent DNA ligase family. (673 aa)
	T1HJS6_RHOPR	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (652 aa)

Your Current Organism:

Rhodnius prolixus

NCBI taxonomy Id: 13249
Other names: R. prolixus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
R4FKD6_RHOPR	R4FND4_RHOPR	R4FKD6	R4FND4	Checkpoint protein; Belongs to the HUS1 family.	Putative dna repair protein rhp57.	0.565
R4FKD6_RHOPR	R4G4E3_RHOPR	R4FKD6	R4G4E3	Checkpoint protein; Belongs to the HUS1 family.	Uncharacterized protein.	0.433
R4FKD6_RHOPR	T1HDX0_RHOPR	R4FKD6	T1HDX0	Checkpoint protein; Belongs to the HUS1 family.	Uncharacterized protein; Belongs to the ATP-dependent DNA ligase family.	0.628
R4FKD6_RHOPR	T1HJS6_RHOPR	R4FKD6	T1HJS6	Checkpoint protein; Belongs to the HUS1 family.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.838
R4FKD6_RHOPR	T1HLU9_RHOPR	R4FKD6	T1HLU9	Checkpoint protein; Belongs to the HUS1 family.	Helicase ATP-binding domain-containing protein.	0.656
R4FKD6_RHOPR	T1HN14_RHOPR	R4FKD6	T1HN14	Checkpoint protein; Belongs to the HUS1 family.	FAT domain-containing protein.	0.838
R4FKD6_RHOPR	T1HNB6_RHOPR	R4FKD6	T1HNB6	Checkpoint protein; Belongs to the HUS1 family.	Rad51 domain-containing protein.	0.633
R4FKD6_RHOPR	T1HS80_RHOPR	R4FKD6	T1HS80	Checkpoint protein; Belongs to the HUS1 family.	Zinc-hook domain-containing protein.	0.643
R4FKD6_RHOPR	T1HTA7_RHOPR	R4FKD6	T1HTA7	Checkpoint protein; Belongs to the HUS1 family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.827
R4FKD6_RHOPR	T1I0G2_RHOPR	R4FKD6	T1I0G2	Checkpoint protein; Belongs to the HUS1 family.	DUF3385 domain-containing protein.	0.838
R4FKD6_RHOPR	T1I325_RHOPR	R4FKD6	T1I325	Checkpoint protein; Belongs to the HUS1 family.	Ku domain-containing protein.	0.601
R4FKD6_RHOPR	T1I572_RHOPR	R4FKD6	T1I572	Checkpoint protein; Belongs to the HUS1 family.	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family.	0.847
R4FKD6_RHOPR	T1I6W3_RHOPR	R4FKD6	T1I6W3	Checkpoint protein; Belongs to the HUS1 family.	FAT domain-containing protein.	0.854
R4FKD6_RHOPR	T1I7Y7_RHOPR	R4FKD6	T1I7Y7	Checkpoint protein; Belongs to the HUS1 family.	Ku domain-containing protein.	0.433
R4FND4_RHOPR	R4FKD6_RHOPR	R4FND4	R4FKD6	Putative dna repair protein rhp57.	Checkpoint protein; Belongs to the HUS1 family.	0.565
R4FND4_RHOPR	R4G4E3_RHOPR	R4FND4	R4G4E3	Putative dna repair protein rhp57.	Uncharacterized protein.	0.470
R4FND4_RHOPR	T1HDX0_RHOPR	R4FND4	T1HDX0	Putative dna repair protein rhp57.	Uncharacterized protein; Belongs to the ATP-dependent DNA ligase family.	0.621
R4FND4_RHOPR	T1HJS6_RHOPR	R4FND4	T1HJS6	Putative dna repair protein rhp57.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.572
R4FND4_RHOPR	T1HLU9_RHOPR	R4FND4	T1HLU9	Putative dna repair protein rhp57.	Helicase ATP-binding domain-containing protein.	0.797
R4FND4_RHOPR	T1HN14_RHOPR	R4FND4	T1HN14	Putative dna repair protein rhp57.	FAT domain-containing protein.	0.572