(146 nodes) Regulation of protein phosphorylation network (Rhodnius prolixus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	R4FLD6_RHOPR	Small ubiquitin-related modifier. (94 aa)
	T1IGJ3_RHOPR	FERM domain-containing protein. (585 aa)
	T1IGD4_RHOPR	Rad60-SLD domain-containing protein. (215 aa)
	T1IGB1_RHOPR	J domain-containing protein. (339 aa)
	T1IFT7_RHOPR	Uncharacterized protein; Belongs to the cyclin family. (349 aa)
	T1IFE5_RHOPR	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (76 aa)
	T1IF73_RHOPR	Uncharacterized protein. (268 aa)
	T1IEZ7_RHOPR	Uncharacterized protein. (434 aa)
	T1IES0_RHOPR	Protein kinase domain-containing protein. (118 aa)
	T1IER8_RHOPR	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (215 aa)
	T1IDV6_RHOPR	WD_REPEATS_REGION domain-containing protein. (1263 aa)
	T1IDS2_RHOPR	Uncharacterized protein. (265 aa)
	T1ICZ2_RHOPR	Uncharacterized protein. (402 aa)
	T1ICV7_RHOPR	Uncharacterized protein. (147 aa)
	T1IBE0_RHOPR	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (603 aa)
	T1IB70_RHOPR	Uncharacterized protein. (192 aa)
	T1IAX7_RHOPR	Uncharacterized protein. (706 aa)
	T1IAS0_RHOPR	Uncharacterized protein. (510 aa)
	T1IAN6_RHOPR	Glass boat bottom. BMP ligand. (422 aa)
	T1IAE4_RHOPR	Uncharacterized protein. (181 aa)
	T1IAD2_RHOPR	Uncharacterized protein. (321 aa)
	T1IAD0_RHOPR	Uncharacterized protein. (253 aa)
	T1IAA9_RHOPR	Uncharacterized protein. (256 aa)
	T1I9S3_RHOPR	Protein kinase domain-containing protein. (522 aa)
	T1I8W3_RHOPR	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (386 aa)
	T1I8U2_RHOPR	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (866 aa)
	T1I8C1_RHOPR	Uncharacterized protein. (473 aa)
	T1I7Y7_RHOPR	Ku domain-containing protein. (351 aa)
	T1I7Q5_RHOPR	Uncharacterized protein. (249 aa)
	T1I7M3_RHOPR	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (397 aa)
	T1I6Y7_RHOPR	Uncharacterized protein. (467 aa)
	T1I5M8_RHOPR	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (345 aa)
	T1I558_RHOPR	Peptidase_M14 domain-containing protein. (214 aa)
	T1I514_RHOPR	Uncharacterized protein. (572 aa)
	T1I510_RHOPR	Uncharacterized protein. (343 aa)
	T1I4N7_RHOPR	TGFb_propeptide domain-containing protein. (184 aa)
	T1I4N3_RHOPR	TGF_BETA_2 domain-containing protein. (197 aa)
	T1I496_RHOPR	TGF_BETA_2 domain-containing protein. (171 aa)
	T1I3X2_RHOPR	Tyrosine-protein kinase Ksr. (918 aa)
	T1I3T8_RHOPR	Uncharacterized protein. (742 aa)
	T1I3K4_RHOPR	PID domain-containing protein. (403 aa)
	T1I311_RHOPR	MH1 domain-containing protein. (121 aa)
	T1I136_RHOPR	DBF4-type domain-containing protein. (1013 aa)
	T1I0S0_RHOPR	Tuberin domain-containing protein. (152 aa)
	T1I097_RHOPR	IlGF domain-containing protein. (98 aa)
	T1HZZ6_RHOPR	Uncharacterized protein. (432 aa)
	T1HZU0_RHOPR	Uncharacterized protein. (229 aa)
	T1HZ23_RHOPR	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1055 aa)
	T1HYE3_RHOPR	Uncharacterized protein. (281 aa)
	T1HYA6_RHOPR	Helicase C-terminal domain-containing protein. (634 aa)
	T1HXR9_RHOPR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2448 aa)
	T1HXJ7_RHOPR	ATG11 domain-containing protein. (1059 aa)
	T1HX66_RHOPR	Cyclin N-terminal domain-containing protein. (84 aa)
	T1HX65_RHOPR	Uncharacterized protein. (116 aa)
	T1HX25_RHOPR	Uncharacterized protein. (413 aa)
	T1HWZ0_RHOPR	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (709 aa)
	T1HWY4_RHOPR	CTCK domain-containing protein. (265 aa)
	T1HWL5_RHOPR	Uncharacterized protein. (143 aa)
	T1HWL4_RHOPR	Uncharacterized protein. (169 aa)
	T1HW40_RHOPR	Uncharacterized protein. (251 aa)
	T1HVU8_RHOPR	Uncharacterized protein. (381 aa)
	T1HV28_RHOPR	Uncharacterized protein. (415 aa)
	T1HUL2_RHOPR	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1334 aa)
	T1HUC4_RHOPR	Uncharacterized protein. (193 aa)
	T1HU31_RHOPR	PPM-type phosphatase domain-containing protein. (374 aa)
	T1HT34_RHOPR	Uncharacterized protein. (1352 aa)
	T1HST5_RHOPR	CYCLIN domain-containing protein; Belongs to the cyclin family. (216 aa)
	T1HSP3_RHOPR	Uncharacterized protein. (1568 aa)
	T1HS48_RHOPR	Uncharacterized protein. (64 aa)
	T1HRP0_RHOPR	IPPc domain-containing protein. (157 aa)
	T1HRA7_RHOPR	Uncharacterized protein. (400 aa)
	T1HQW0_RHOPR	Uncharacterized protein. (207 aa)
	T1HQR1_RHOPR	FERM domain-containing protein. (363 aa)
	T1HQJ2_RHOPR	Uncharacterized protein. (145 aa)
	T1HQG2_RHOPR	Uncharacterized protein. (218 aa)
	T1HP86_RHOPR	Uncharacterized protein. (270 aa)
	T1HP46_RHOPR	Uncharacterized protein. (299 aa)
	T1HNP2_RHOPR	PP1c_bdg domain-containing protein. (390 aa)
	T1HNA7_RHOPR	PPM-type phosphatase domain-containing protein. (462 aa)
	T1HNA4_RHOPR	Protein kinase domain-containing protein. (1314 aa)
	T1HN05_RHOPR	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (437 aa)
	T1HMY0_RHOPR	Uncharacterized protein. (234 aa)
	T1HMR6_RHOPR	TPX2 domain-containing protein. (150 aa)
	T1HMP5_RHOPR	Uncharacterized protein. (270 aa)
	T1HLY2_RHOPR	Uncharacterized protein. (659 aa)
	T1HLD6_RHOPR	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (91 aa)
	T1HL47_RHOPR	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (293 aa)
	T1HKD0_RHOPR	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (239 aa)
	T1HJC7_RHOPR	Protein kinase domain-containing protein. (1053 aa)
	T1HIW4_RHOPR	Uncharacterized protein. (40 aa)
	T1HIF7_RHOPR	Uncharacterized protein. (1308 aa)
	T1HHV6_RHOPR	Uncharacterized protein. (411 aa)
	T1HH10_RHOPR	Ubiquitin-like domain-containing protein. (90 aa)
	T1HGL5_RHOPR	Uncharacterized protein. (285 aa)
	T1HG94_RHOPR	ANK_REP_REGION domain-containing protein. (206 aa)
	T1HFZ8_RHOPR	SAM domain-containing protein. (124 aa)
	T1HFZ0_RHOPR	Uncharacterized protein. (683 aa)
	T1HFY5_RHOPR	Uncharacterized protein. (406 aa)
	T1HFN4_RHOPR	Ig-like domain-containing protein. (593 aa)
	T1HFN3_RHOPR	Uncharacterized protein. (410 aa)
	T1HFD3_RHOPR	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (327 aa)
	T1HEP1_RHOPR	Protein kinase domain-containing protein. (167 aa)
	T1HEE8_RHOPR	Non-specific serine/threonine protein kinase. (699 aa)
	T1HE37_RHOPR	Uncharacterized protein. (116 aa)
	T1HDJ5_RHOPR	Uncharacterized protein. (414 aa)
	T1HD40_RHOPR	TGF_BETA_2 domain-containing protein. (272 aa)
	T1HCY2_RHOPR	Uncharacterized protein. (192 aa)
	T1HC72_RHOPR	Uncharacterized protein. (594 aa)
	T1HBX0_RHOPR	Uncharacterized protein. (602 aa)
	T1HBQ6_RHOPR	Uncharacterized protein. (998 aa)
	T1HB09_RHOPR	Uncharacterized protein. (166 aa)
	T1HAY2_RHOPR	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (393 aa)
	T1HAK6_RHOPR	IRS-type PTB domain-containing protein. (346 aa)
	T1HAI0_RHOPR	Uncharacterized protein. (307 aa)
	T1HA38_RHOPR	Uncharacterized protein. (222 aa)
	T1HA31_RHOPR	Uncharacterized protein. (267 aa)
	T1H9X7_RHOPR	BTB domain-containing protein. (307 aa)
	T1H9W0_RHOPR	Protein kinase domain-containing protein. (105 aa)
	T1H9U4_RHOPR	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (488 aa)
	T1H9J9_RHOPR	TGF_BETA_2 domain-containing protein. (147 aa)
	T1H9I0_RHOPR	Uncharacterized protein. (88 aa)
	T1H9E3_RHOPR	Uncharacterized protein. (753 aa)
	T1H9C4_RHOPR	Uncharacterized protein. (453 aa)
	T1H8D0_RHOPR	Uncharacterized protein. (2138 aa)
	T1H831_RHOPR	Double-time; Belongs to the protein kinase superfamily. (359 aa)
	T1H821_RHOPR	Uncharacterized protein. (95 aa)
	T1H806_RHOPR	ARTD15_N domain-containing protein. (452 aa)
	R4G8Q4_RHOPR	Serine/threonine-protein phosphatase. (309 aa)
	R4G8L9_RHOPR	Putative ras-like gtp-binding protein rho1 isoform 1. (193 aa)
	R4G8I3_RHOPR	Putative ribosomal protein p1; Belongs to the eukaryotic ribosomal protein P1/P2 family. (116 aa)
	R4G897_RHOPR	Protein BCCIP homolog; Belongs to the BCP1 family. (300 aa)
	R4G5J1_RHOPR	Putative microtubule-binding protein involved in cell cycle control. (373 aa)
	R4G5I6_RHOPR	Putative cyclin; Belongs to the cyclin family. (342 aa)
	R4G4R2_RHOPR	Guanine nucleotide-binding protein subunit beta-like protein. (318 aa)
	R4G4N6_RHOPR	Putative ras-like gtp-binding protein rhoa. (187 aa)
	R4G4E3_RHOPR	Uncharacterized protein. (128 aa)
	R4G4B6_RHOPR	Putative fgfr1 oncoprotein partner isoform b. (336 aa)
	R4G464_RHOPR	Putative camp-dependent protein kinase r2. (378 aa)
	R4G445_RHOPR	Putative e3 ubiquitin ligase. (315 aa)
	R4G396_RHOPR	PIP49_C domain-containing protein. (384 aa)
	R4G2X9_RHOPR	Putative cdk activating kin; Belongs to the cyclin family. (329 aa)
	R4FPN2_RHOPR	Putative apoptosis related protein. (210 aa)
	R4FP87_RHOPR	Putative eif 2a kinase. (551 aa)
	R4FNX0_RHOPR	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (723 aa)
	R4FMW9_RHOPR	Putative translationally controlled tumor protein; Belongs to the TCTP family. (172 aa)
	R4FLT2_RHOPR	Putative cell cycle-associated protein. (226 aa)

Your Current Organism:

Rhodnius prolixus

NCBI taxonomy Id: 13249
Other names: R. prolixus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
R4FLD6_RHOPR	R4FMW9_RHOPR	R4FLD6	R4FMW9	Small ubiquitin-related modifier.	Putative translationally controlled tumor protein; Belongs to the TCTP family.	0.400
R4FLD6_RHOPR	T1HLY2_RHOPR	R4FLD6	T1HLY2	Small ubiquitin-related modifier.	Uncharacterized protein.	0.625
R4FLD6_RHOPR	T1HYA6_RHOPR	R4FLD6	T1HYA6	Small ubiquitin-related modifier.	Helicase C-terminal domain-containing protein.	0.473
R4FLD6_RHOPR	T1HYE3_RHOPR	R4FLD6	T1HYE3	Small ubiquitin-related modifier.	Uncharacterized protein.	0.473
R4FLD6_RHOPR	T1IBE0_RHOPR	R4FLD6	T1IBE0	Small ubiquitin-related modifier.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.	0.446
R4FMW9_RHOPR	R4FLD6_RHOPR	R4FMW9	R4FLD6	Putative translationally controlled tumor protein; Belongs to the TCTP family.	Small ubiquitin-related modifier.	0.400
R4FMW9_RHOPR	R4G4R2_RHOPR	R4FMW9	R4G4R2	Putative translationally controlled tumor protein; Belongs to the TCTP family.	Guanine nucleotide-binding protein subunit beta-like protein.	0.981
R4FMW9_RHOPR	R4G8I3_RHOPR	R4FMW9	R4G8I3	Putative translationally controlled tumor protein; Belongs to the TCTP family.	Putative ribosomal protein p1; Belongs to the eukaryotic ribosomal protein P1/P2 family.	0.960
R4FMW9_RHOPR	T1IGD4_RHOPR	R4FMW9	T1IGD4	Putative translationally controlled tumor protein; Belongs to the TCTP family.	Rad60-SLD domain-containing protein.	0.400
R4FNX0_RHOPR	R4G445_RHOPR	R4FNX0	R4G445	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	Putative e3 ubiquitin ligase.	0.661
R4FNX0_RHOPR	R4G4E3_RHOPR	R4FNX0	R4G4E3	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	Uncharacterized protein.	0.410
R4FNX0_RHOPR	T1HX25_RHOPR	R4FNX0	T1HX25	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	Uncharacterized protein.	0.614
R4FNX0_RHOPR	T1HX65_RHOPR	R4FNX0	T1HX65	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	Uncharacterized protein.	0.614
R4FNX0_RHOPR	T1HX66_RHOPR	R4FNX0	T1HX66	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	Cyclin N-terminal domain-containing protein.	0.614
R4FNX0_RHOPR	T1HYA6_RHOPR	R4FNX0	T1HYA6	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	Helicase C-terminal domain-containing protein.	0.402
R4FNX0_RHOPR	T1HYE3_RHOPR	R4FNX0	T1HYE3	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	Uncharacterized protein.	0.402
R4FNX0_RHOPR	T1I5M8_RHOPR	R4FNX0	T1I5M8	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.668
R4FNX0_RHOPR	T1I7Y7_RHOPR	R4FNX0	T1I7Y7	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	Ku domain-containing protein.	0.410
R4FNX0_RHOPR	T1IFT7_RHOPR	R4FNX0	T1IFT7	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	Uncharacterized protein; Belongs to the cyclin family.	0.774
R4FP87_RHOPR	R4G4R2_RHOPR	R4FP87	R4G4R2	Putative eif 2a kinase.	Guanine nucleotide-binding protein subunit beta-like protein.	0.446