(43 nodes) Negative regulation of MAPK cascade network (Rhodnius prolixus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	T1HG94_RHOPR	ANK_REP_REGION domain-containing protein. (206 aa)
	T1HD03_RHOPR	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (294 aa)
	T1HCP5_RHOPR	RING-type domain-containing protein. (373 aa)
	T1HCK5_RHOPR	WD_REPEATS_REGION domain-containing protein. (388 aa)
	T1HA38_RHOPR	Uncharacterized protein. (222 aa)
	T1HA14_RHOPR	SAC domain-containing protein. (601 aa)
	T1H9K0_RHOPR	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (192 aa)
	T1H8D0_RHOPR	Uncharacterized protein. (2138 aa)
	R4G887_RHOPR	Putative phosphoglucosamine acetyltransferase. (200 aa)
	R4G5G6_RHOPR	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (287 aa)
	R4G531_RHOPR	Putative ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	T1HN75_RHOPR	JmjC domain-containing protein. (373 aa)
	T1HN74_RHOPR	Uncharacterized protein. (201 aa)
	T1HMP5_RHOPR	Uncharacterized protein. (270 aa)
	T1IEI6_RHOPR	Uncharacterized protein. (149 aa)
	T1ICJ0_RHOPR	Uncharacterized protein. (432 aa)
	T1IB75_RHOPR	Uncharacterized protein. (271 aa)
	T1IB74_RHOPR	Uncharacterized protein. (137 aa)
	T1IB73_RHOPR	Uncharacterized protein. (184 aa)
	T1IB71_RHOPR	Uncharacterized protein. (175 aa)
	T1IAL3_RHOPR	Uncharacterized protein. (169 aa)
	T1IAL1_RHOPR	Uncharacterized protein. (179 aa)
	T1I949_RHOPR	Uncharacterized protein. (787 aa)
	T1I943_RHOPR	Serine/threonine-protein phosphatase. (309 aa)
	T1I5F2_RHOPR	Uncharacterized protein. (387 aa)
	T1I3T8_RHOPR	Uncharacterized protein. (742 aa)
	T1HZY5_RHOPR	PPM-type phosphatase domain-containing protein. (366 aa)
	T1HZF3_RHOPR	Uncharacterized protein. (612 aa)
	T1HZ40_RHOPR	Uncharacterized protein. (2641 aa)
	T1HYM4_RHOPR	WH1 domain-containing protein. (393 aa)
	T1HV24_RHOPR	Phosphoinositide phospholipase C. (1226 aa)
	T1HUR3_RHOPR	Uncharacterized protein. (432 aa)
	T1HU48_RHOPR	ANK_REP_REGION domain-containing protein. (1091 aa)
	T1HTG7_RHOPR	Uncharacterized protein. (566 aa)
	T1HSJ5_RHOPR	Rhodanese domain-containing protein. (199 aa)
	T1HD86_RHOPR	Uncharacterized protein. (709 aa)
	T1HP17_RHOPR	Uncharacterized protein. (499 aa)
	T1HIQ8_RHOPR	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (275 aa)
	T1IF32_RHOPR	Uncharacterized protein. (348 aa)
	T1HGL5_RHOPR	Uncharacterized protein. (285 aa)
	T1HI54_RHOPR	Non-specific serine/threonine protein kinase. (718 aa)
	T1HE43_RHOPR	Uncharacterized protein. (798 aa)
	T1HDJ5_RHOPR	Uncharacterized protein. (414 aa)

Your Current Organism:

Rhodnius prolixus

NCBI taxonomy Id: 13249
Other names: R. prolixus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
R4G531_RHOPR	T1HCP5_RHOPR	R4G531	T1HCP5	Putative ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family.	RING-type domain-containing protein.	0.576
R4G531_RHOPR	T1HG94_RHOPR	R4G531	T1HG94	Putative ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family.	ANK_REP_REGION domain-containing protein.	0.454
R4G5G6_RHOPR	T1HIQ8_RHOPR	R4G5G6	T1HIQ8	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.999
R4G5G6_RHOPR	T1HU48_RHOPR	R4G5G6	T1HU48	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	ANK_REP_REGION domain-containing protein.	0.667
T1H8D0_RHOPR	T1H9K0_RHOPR	T1H8D0	T1H9K0	Uncharacterized protein.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.663
T1H8D0_RHOPR	T1HA14_RHOPR	T1H8D0	T1HA14	Uncharacterized protein.	SAC domain-containing protein.	0.828
T1H8D0_RHOPR	T1HD03_RHOPR	T1H8D0	T1HD03	Uncharacterized protein.	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.669
T1H8D0_RHOPR	T1HDJ5_RHOPR	T1H8D0	T1HDJ5	Uncharacterized protein.	Uncharacterized protein.	0.663
T1H8D0_RHOPR	T1HN74_RHOPR	T1H8D0	T1HN74	Uncharacterized protein.	Uncharacterized protein.	0.595
T1H8D0_RHOPR	T1HSJ5_RHOPR	T1H8D0	T1HSJ5	Uncharacterized protein.	Rhodanese domain-containing protein.	0.669
T1H8D0_RHOPR	T1HV24_RHOPR	T1H8D0	T1HV24	Uncharacterized protein.	Phosphoinositide phospholipase C.	0.446
T1H8D0_RHOPR	T1I5F2_RHOPR	T1H8D0	T1I5F2	Uncharacterized protein.	Uncharacterized protein.	0.692
T1H9K0_RHOPR	T1H8D0_RHOPR	T1H9K0	T1H8D0	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein.	0.663
T1H9K0_RHOPR	T1HE43_RHOPR	T1H9K0	T1HE43	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein.	0.528
T1H9K0_RHOPR	T1I5F2_RHOPR	T1H9K0	T1I5F2	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein.	0.469
T1HA14_RHOPR	T1H8D0_RHOPR	T1HA14	T1H8D0	SAC domain-containing protein.	Uncharacterized protein.	0.828
T1HA38_RHOPR	T1I3T8_RHOPR	T1HA38	T1I3T8	Uncharacterized protein.	Uncharacterized protein.	0.992
T1HA38_RHOPR	T1I943_RHOPR	T1HA38	T1I943	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.603
T1HCK5_RHOPR	T1I949_RHOPR	T1HCK5	T1I949	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.962
T1HCP5_RHOPR	R4G531_RHOPR	T1HCP5	R4G531	RING-type domain-containing protein.	Putative ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family.	0.576