(67 nodes) Signaling by Insulin receptor network (Rhodnius prolixus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T1HZP9_RHOPR	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (495 aa)
	T1HC48_RHOPR	Protein kinase domain-containing protein. (341 aa)
	T1HCF6_RHOPR	Uncharacterized protein. (1156 aa)
	T1HD50_RHOPR	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (716 aa)
	T1HEP1_RHOPR	Protein kinase domain-containing protein. (167 aa)
	T1HGE0_RHOPR	Uncharacterized protein. (226 aa)
	T1HI64_RHOPR	Uncharacterized protein. (189 aa)
	T1HKM5_RHOPR	PWWP domain-containing protein. (509 aa)
	T1HLC5_RHOPR	Uncharacterized protein. (102 aa)
	T1HLE2_RHOPR	Uncharacterized protein. (150 aa)
	T1HMJ1_RHOPR	Uncharacterized protein. (301 aa)
	T1HNC4_RHOPR	Fe2OG dioxygenase domain-containing protein. (260 aa)
	T1HQC7_RHOPR	Receptor protein-tyrosine kinase. (1249 aa)
	T1HSG5_RHOPR	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (451 aa)
	T1HSZ9_RHOPR	Uncharacterized protein. (219 aa)
	T1HUR3_RHOPR	Uncharacterized protein. (432 aa)
	T1HVD1_RHOPR	Uncharacterized protein. (682 aa)
	T1HVZ3_RHOPR	Receptor protein-tyrosine kinase (Fragment). (847 aa)
	T1HWF6_RHOPR	Uncharacterized protein. (145 aa)
	T1HWI3_RHOPR	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (890 aa)
	T1HWM7_RHOPR	PH domain-containing protein. (72 aa)
	T1HXG0_RHOPR	Uncharacterized protein. (515 aa)
	T1HBF3_RHOPR	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (381 aa)
	T1HB35_RHOPR	Tyrosine-protein kinase receptor. (2263 aa)
	T1HAZ3_RHOPR	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (197 aa)
	T1HAZ2_RHOPR	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (502 aa)
	T1HAU5_RHOPR	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (372 aa)
	T1HAM3_RHOPR	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (532 aa)
	T1HAB1_RHOPR	Uncharacterized protein. (418 aa)
	T1H9Y5_RHOPR	Protein kinase domain-containing protein. (303 aa)
	T1H9W0_RHOPR	Protein kinase domain-containing protein. (105 aa)
	T1H821_RHOPR	Uncharacterized protein. (95 aa)
	T1H7T3_RHOPR	Uncharacterized protein. (236 aa)
	R4G8R2_RHOPR	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (348 aa)
	R4G8H4_RHOPR	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (85 aa)
	R4G8G8_RHOPR	Putative v-atpase subunit a. (613 aa)
	R4G878_RHOPR	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (116 aa)
	R4G5L0_RHOPR	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (482 aa)
	R4G4K3_RHOPR	Putative beta-glucosidase; Belongs to the glycosyl hydrolase 1 family. (470 aa)
	R4G493_RHOPR	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (85 aa)
	R4G471_RHOPR	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (117 aa)
	R4G439_RHOPR	Putative vacuolar atp synthase subunit e. (250 aa)
	R4G3Z1_RHOPR	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (123 aa)
	R4FN52_RHOPR	Putative vacuolar atp synthase 21 kDa proteolipid subunit; Belongs to the V-ATPase proteolipid subunit family. (210 aa)
	R4FMV1_RHOPR	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (157 aa)
	R4FL23_RHOPR	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (121 aa)
	T1HZ23_RHOPR	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1055 aa)
	T1HZE1_RHOPR	Uncharacterized protein. (100 aa)
	T1HZG0_RHOPR	Recep_L_domain domain-containing protein. (248 aa)
	T1HZG1_RHOPR	Pkinase_Tyr domain-containing protein. (135 aa)
	T1HBF8_RHOPR	IRS-type PTB domain-containing protein. (344 aa)
	T1HZR0_RHOPR	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (495 aa)
	T1I122_RHOPR	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (494 aa)
	T1I409_RHOPR	Uncharacterized protein. (380 aa)
	T1I4F0_RHOPR	Uncharacterized protein. (1230 aa)
	T1I5Y1_RHOPR	Rho-GAP domain-containing protein. (159 aa)
	T1I5Y3_RHOPR	Uncharacterized protein. (162 aa)
	T1I5Y5_RHOPR	Uncharacterized protein. (414 aa)
	T1I9S3_RHOPR	Protein kinase domain-containing protein. (522 aa)
	T1I9Y4_RHOPR	Tyrosine-protein kinase Cad96Ca; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1163 aa)
	T1IA43_RHOPR	Uncharacterized protein. (253 aa)
	T1IB68_RHOPR	Uncharacterized protein. (275 aa)
	T1IC14_RHOPR	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (87 aa)
	T1ICB5_RHOPR	Uncharacterized protein. (1906 aa)
	T1IF73_RHOPR	Uncharacterized protein. (268 aa)
	T1IGB3_RHOPR	Uncharacterized protein. (535 aa)
	T1IGN2_RHOPR	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (455 aa)

Your Current Organism:

Rhodnius prolixus

NCBI taxonomy Id: 13249
Other names: R. prolixus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
R4FL23_RHOPR	R4FMV1_RHOPR	R4FL23	R4FMV1	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.994
R4FL23_RHOPR	R4FN52_RHOPR	R4FL23	R4FN52	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Putative vacuolar atp synthase 21 kDa proteolipid subunit; Belongs to the V-ATPase proteolipid subunit family.	0.994
R4FL23_RHOPR	R4G439_RHOPR	R4FL23	R4G439	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Putative vacuolar atp synthase subunit e.	0.988
R4FL23_RHOPR	R4G471_RHOPR	R4FL23	R4G471	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.997
R4FL23_RHOPR	R4G493_RHOPR	R4FL23	R4G493	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.973
R4FL23_RHOPR	R4G5L0_RHOPR	R4FL23	R4G5L0	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.	0.996
R4FL23_RHOPR	R4G878_RHOPR	R4FL23	R4G878	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.997
R4FL23_RHOPR	R4G8G8_RHOPR	R4FL23	R4G8G8	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Putative v-atpase subunit a.	0.999
R4FL23_RHOPR	R4G8H4_RHOPR	R4FL23	R4G8H4	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.973
R4FL23_RHOPR	R4G8R2_RHOPR	R4FL23	R4G8R2	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.997
R4FL23_RHOPR	T1HAB1_RHOPR	R4FL23	T1HAB1	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Uncharacterized protein.	0.977
R4FL23_RHOPR	T1HAU5_RHOPR	R4FL23	T1HAU5	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.993
R4FL23_RHOPR	T1HAZ2_RHOPR	R4FL23	T1HAZ2	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.969
R4FL23_RHOPR	T1HAZ3_RHOPR	R4FL23	T1HAZ3	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.969
R4FL23_RHOPR	T1HBF3_RHOPR	R4FL23	T1HBF3	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.993
R4FL23_RHOPR	T1HD50_RHOPR	R4FL23	T1HD50	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.969
R4FL23_RHOPR	T1HGE0_RHOPR	R4FL23	T1HGE0	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Uncharacterized protein.	0.988
R4FL23_RHOPR	T1HI64_RHOPR	R4FL23	T1HI64	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Uncharacterized protein.	0.988
R4FL23_RHOPR	T1HKM5_RHOPR	R4FL23	T1HKM5	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	PWWP domain-containing protein.	0.856
R4FL23_RHOPR	T1HLC5_RHOPR	R4FL23	T1HLC5	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Uncharacterized protein.	0.993