(27 nodes) Ubiquinone and other terpenoid-quinone biosynthesis network (Rhodnius prolixus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	R4G3T1_RHOPR	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (208 aa)
	T1H994_RHOPR	ABC transmembrane type-1 domain-containing protein. (433 aa)
	T1H9C5_RHOPR	FAD_binding_3 domain-containing protein. (393 aa)
	T1H9P6_RHOPR	FAD_binding_3 domain-containing protein. (394 aa)
	T1HAP0_RHOPR	AB hydrolase-1 domain-containing protein. (333 aa)
	T1HAQ2_RHOPR	Uncharacterized protein. (204 aa)
	T1HAQ3_RHOPR	Uncharacterized protein. (344 aa)
	T1HAY4_RHOPR	Uncharacterized protein. (225 aa)
	T1HC96_RHOPR	Uncharacterized protein. (162 aa)
	T1HC97_RHOPR	SAP domain-containing protein. (905 aa)
	coq2	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (356 aa)
	T1HIK5_RHOPR	4-hydroxyphenylpyruvate dioxygenase. (221 aa)
	T1HK11_RHOPR	Uncharacterized protein. (572 aa)
	T1HQP3_RHOPR	Uncharacterized protein. (215 aa)
	T1HRN1_RHOPR	AMP-binding domain-containing protein. (172 aa)
	T1HSY4_RHOPR	Uncharacterized protein. (261 aa)
	coq3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (272 aa)
	T1HXZ9_RHOPR	Uncharacterized protein. (988 aa)
	coq6	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (446 aa)
	coq5	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (275 aa)
	coq7	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (198 aa)
	T1HW64_RHOPR	4HBT domain-containing protein. (144 aa)
	T1HWG1_RHOPR	Uncharacterized protein. (494 aa)
	T1I648_RHOPR	Uncharacterized protein. (224 aa)
	T1H8X8_RHOPR	AB hydrolase-1 domain-containing protein. (311 aa)
	T1H8K0_RHOPR	AB hydrolase-1 domain-containing protein. (306 aa)
	T1H7X8_RHOPR	Uncharacterized protein. (576 aa)

Your Current Organism:

Rhodnius prolixus

NCBI taxonomy Id: 13249
Other names: R. prolixus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1H7X8_RHOPR	T1H8K0_RHOPR	T1H7X8	T1H8K0	Uncharacterized protein.	AB hydrolase-1 domain-containing protein.	0.429
T1H7X8_RHOPR	T1H8X8_RHOPR	T1H7X8	T1H8X8	Uncharacterized protein.	AB hydrolase-1 domain-containing protein.	0.429
T1H7X8_RHOPR	T1HAP0_RHOPR	T1H7X8	T1HAP0	Uncharacterized protein.	AB hydrolase-1 domain-containing protein.	0.429
T1H7X8_RHOPR	T1HAQ3_RHOPR	T1H7X8	T1HAQ3	Uncharacterized protein.	Uncharacterized protein.	0.424
T1H7X8_RHOPR	T1HWG1_RHOPR	T1H7X8	T1HWG1	Uncharacterized protein.	Uncharacterized protein.	0.418
T1H8K0_RHOPR	T1H7X8_RHOPR	T1H8K0	T1H7X8	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.429
T1H8K0_RHOPR	T1H994_RHOPR	T1H8K0	T1H994	AB hydrolase-1 domain-containing protein.	ABC transmembrane type-1 domain-containing protein.	0.429
T1H8K0_RHOPR	T1H9C5_RHOPR	T1H8K0	T1H9C5	AB hydrolase-1 domain-containing protein.	FAD_binding_3 domain-containing protein.	0.460
T1H8K0_RHOPR	T1H9P6_RHOPR	T1H8K0	T1H9P6	AB hydrolase-1 domain-containing protein.	FAD_binding_3 domain-containing protein.	0.460
T1H8K0_RHOPR	T1HAQ2_RHOPR	T1H8K0	T1HAQ2	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.429
T1H8K0_RHOPR	T1HAQ3_RHOPR	T1H8K0	T1HAQ3	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.429
T1H8K0_RHOPR	T1HAY4_RHOPR	T1H8K0	T1HAY4	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.429
T1H8K0_RHOPR	T1HK11_RHOPR	T1H8K0	T1HK11	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.429
T1H8K0_RHOPR	T1HRN1_RHOPR	T1H8K0	T1HRN1	AB hydrolase-1 domain-containing protein.	AMP-binding domain-containing protein.	0.429
T1H8K0_RHOPR	T1HWG1_RHOPR	T1H8K0	T1HWG1	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.429
T1H8K0_RHOPR	T1HXZ9_RHOPR	T1H8K0	T1HXZ9	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.429
T1H8K0_RHOPR	coq3	T1H8K0	T1HU35	AB hydrolase-1 domain-containing protein.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.733
T1H8K0_RHOPR	coq6	T1H8K0	R4FK38	AB hydrolase-1 domain-containing protein.	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	0.460
T1H8X8_RHOPR	T1H7X8_RHOPR	T1H8X8	T1H7X8	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.429
T1H8X8_RHOPR	T1H994_RHOPR	T1H8X8	T1H994	AB hydrolase-1 domain-containing protein.	ABC transmembrane type-1 domain-containing protein.	0.429