(100 nodes) Glycerophospholipid metabolism network (Rhodnius prolixus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T1HP75_RHOPR	Spondin domain-containing protein. (215 aa)
	T1HNX3_RHOPR	Glycerol-3-phosphate dehydrogenase [NAD(+)]. (356 aa)
	T1HMB2_RHOPR	PLD phosphodiesterase domain-containing protein. (147 aa)
	T1HLX5_RHOPR	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (491 aa)
	T1HKB2_RHOPR	acidPPc domain-containing protein. (287 aa)
	T1HK80_RHOPR	Uncharacterized protein. (224 aa)
	T1HII7_RHOPR	Uncharacterized protein. (98 aa)
	T1HIF7_RHOPR	Uncharacterized protein. (1308 aa)
	T1HHM1_RHOPR	Uncharacterized protein. (70 aa)
	T1HHI6_RHOPR	C2 domain-containing protein. (324 aa)
	T1HG41_RHOPR	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
	T1HFM5_RHOPR	GP-PDE domain-containing protein. (367 aa)
	T1HFI9_RHOPR	Uncharacterized protein. (368 aa)
	T1HEF2_RHOPR	Uncharacterized protein. (197 aa)
	T1HED3_RHOPR	Uncharacterized protein. (324 aa)
	T1HDI3_RHOPR	PlsC domain-containing protein. (487 aa)
	T1HD79_RHOPR	Uncharacterized protein. (135 aa)
	T1HCY1_RHOPR	Uncharacterized protein. (365 aa)
	T1HCN6_RHOPR	Uncharacterized protein. (351 aa)
	T1HCG0_RHOPR	Uncharacterized protein. (311 aa)
	T1HC21_RHOPR	PlsC domain-containing protein. (458 aa)
	T1HBT0_RHOPR	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. (349 aa)
	T1HB26_RHOPR	DDHD domain-containing protein. (723 aa)
	T1H9V9_RHOPR	Uncharacterized protein. (601 aa)
	T1H9M2_RHOPR	Diacylglycerol kinase. (375 aa)
	T1H921_RHOPR	Uncharacterized protein. (376 aa)
	T1H8Y3_RHOPR	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (589 aa)
	T1H8W6_RHOPR	DDHD domain-containing protein. (702 aa)
	T1H8S6_RHOPR	Choline-phosphate cytidylyltransferase activity. (356 aa)
	T1H8N5_RHOPR	Ethanolamine-phosphate cytidylyltransferase activity. (321 aa)
	T1H8E6_RHOPR	Ethanolamine-phosphate cytidylyltransferase activity. (215 aa)
	T1H8D1_RHOPR	Lipase_GDSL domain-containing protein. (400 aa)
	T1H875_RHOPR	Lipase domain-containing protein. (370 aa)
	T1H810_RHOPR	Ndr domain. (471 aa)
	T1H7X2_RHOPR	PA2c domain-containing protein. (167 aa)
	T1H7R6_RHOPR	CBM20 domain-containing protein. (278 aa)
	R4G7P3_RHOPR	Putative lysophosphatidylcholine acyltransferase. (404 aa)
	R4G5F9_RHOPR	Ubiquitin thioesterase. (273 aa)
	R4G5F6_RHOPR	Putative phosphatidylinositol transfer protein. (272 aa)
	R4G422_RHOPR	Uncharacterized protein. (180 aa)
	R4G3S7_RHOPR	Uncharacterized protein. (194 aa)
	R4G3G9_RHOPR	Putative lysophospholipase-like 1. (235 aa)
	R4G3D0_RHOPR	Putative sn-1,2-diacylglycerol ethanolamine-and cholinephosphotransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (375 aa)
	R4FPG7_RHOPR	Phosphatidate cytidylyltransferase; Belongs to the CDS family. (418 aa)
	R4FP27_RHOPR	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (374 aa)
	R4FMY2_RHOPR	Putative diacylglycerol cholinephosphotransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (392 aa)
	R4FME3_RHOPR	Putative ancient ubiquitous protein 1. (416 aa)
	R4FL81_RHOPR	Putative motochondrial complex i intermediate-associated protein 30 cia30. (299 aa)
	R4FJU5_RHOPR	Putative cdp-alcohol phosphatidyltransferase/phosphatidylglycerol-phosphate synthase. (285 aa)
	PLA2	Phospholipase A2. (238 aa)
	T1HSE2_RHOPR	Uncharacterized protein. (337 aa)
	T1HVN8_RHOPR	Uncharacterized protein. (1012 aa)
	T1HVP6_RHOPR	Uncharacterized protein. (684 aa)
	T1HX11_RHOPR	PlsC domain-containing protein. (364 aa)
	T1HX47_RHOPR	PA2c domain-containing protein. (274 aa)
	T1HX49_RHOPR	PA2c domain-containing protein. (149 aa)
	T1HXL2_RHOPR	PlsC domain-containing protein. (376 aa)
	T1HXT5_RHOPR	Diacylglycerol kinase. (904 aa)
	T1HZB5_RHOPR	Uncharacterized protein. (287 aa)
	T1I0L5_RHOPR	acidPPc domain-containing protein. (270 aa)
	PLA2XII	Phospholipase A2. (201 aa)
	T1I243_RHOPR	Uncharacterized protein. (653 aa)
	T1I2T0_RHOPR	LNS2 domain-containing protein. (968 aa)
	T1I3H8_RHOPR	PLD phosphodiesterase domain-containing protein. (243 aa)
	T1I4W6_RHOPR	Uncharacterized protein. (369 aa)
	T1I592_RHOPR	Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (659 aa)
	T1I5E5_RHOPR	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (469 aa)
	T1I5K0_RHOPR	Abhydrolase_2 domain-containing protein. (114 aa)
	T1I616_RHOPR	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (442 aa)
	T1I636_RHOPR	Choline acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (620 aa)
	T1I7K4_RHOPR	PLD phosphodiesterase domain-containing protein. (210 aa)
	T1I7R7_RHOPR	Uncharacterized protein; Belongs to the fructosamine kinase family. (303 aa)
	T1I852_RHOPR	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. (340 aa)
	T1I879_RHOPR	Uncharacterized protein. (568 aa)
	T1I9R3_RHOPR	Acyltransf_C domain-containing protein. (215 aa)
	T1I9Y6_RHOPR	Diacylglycerol kinase. (895 aa)
	T1IA39_RHOPR	Uncharacterized protein. (343 aa)
	T1IB43_RHOPR	Uncharacterized protein. (172 aa)
	T1IB44_RHOPR	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (492 aa)
	T1ICG0_RHOPR	Uncharacterized protein. (247 aa)
	T1ICJ7_RHOPR	Abhydrolase_2 domain-containing protein. (72 aa)
	T1ICL0_RHOPR	Abhydrolase_2 domain-containing protein. (187 aa)
	T1ICQ8_RHOPR	Uncharacterized protein. (345 aa)
	T1ID18_RHOPR	Diacylglycerol kinase. (841 aa)
	T1ID85_RHOPR	Uncharacterized protein. (451 aa)
	T1IDH0_RHOPR	PLD phosphodiesterase domain-containing protein. (204 aa)
	T1IDK1_RHOPR	Uncharacterized protein. (347 aa)
	T1IDU2_RHOPR	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (238 aa)
	T1IEE9_RHOPR	Uncharacterized protein. (392 aa)
	T1IEG7_RHOPR	Uncharacterized protein. (888 aa)
	T1IEY2_RHOPR	EAL domain-containing protein. (524 aa)
	T1IF98_RHOPR	Uncharacterized protein. (175 aa)
	T1IFB1_RHOPR	ASD2 domain-containing protein. (170 aa)
	T1IFM5_RHOPR	Diacylglycerol kinase. (1459 aa)
	T1IFM8_RHOPR	Tafazzin family protein; Belongs to the taffazin family. (264 aa)
	T1IFQ0_RHOPR	DDHD domain-containing protein. (1244 aa)
	T1HRP5_RHOPR	Glycerol-3-phosphate dehydrogenase [NAD(+)]. (339 aa)
	MED16	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (797 aa)
	T1HQD4_RHOPR	Spondin domain-containing protein. (368 aa)
	T1HPZ9_RHOPR	Abhydrolase_2 domain-containing protein. (163 aa)

Your Current Organism:

Rhodnius prolixus

NCBI taxonomy Id: 13249
Other names: R. prolixus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MED16	R4FJU5_RHOPR	T1HRI3	R4FJU5	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Putative cdp-alcohol phosphatidyltransferase/phosphatidylglycerol-phosphate synthase.	0.798
MED16	R4FME3_RHOPR	T1HRI3	R4FME3	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Putative ancient ubiquitous protein 1.	0.540
MED16	R4FMY2_RHOPR	T1HRI3	R4FMY2	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Putative diacylglycerol cholinephosphotransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.522
MED16	R4FPG7_RHOPR	T1HRI3	R4FPG7	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Phosphatidate cytidylyltransferase; Belongs to the CDS family.	0.626
MED16	R4G3D0_RHOPR	T1HRI3	R4G3D0	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Putative sn-1,2-diacylglycerol ethanolamine-and cholinephosphotransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.522
MED16	R4G3S7_RHOPR	T1HRI3	R4G3S7	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.453
MED16	R4G5F6_RHOPR	T1HRI3	R4G5F6	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Putative phosphatidylinositol transfer protein.	0.434
MED16	R4G7P3_RHOPR	T1HRI3	R4G7P3	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Putative lysophosphatidylcholine acyltransferase.	0.483
MED16	T1H7R6_RHOPR	T1HRI3	T1H7R6	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	CBM20 domain-containing protein.	0.416
MED16	T1H921_RHOPR	T1HRI3	T1H921	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.750
MED16	T1H9M2_RHOPR	T1HRI3	T1H9M2	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Diacylglycerol kinase.	0.462
MED16	T1H9V9_RHOPR	T1HRI3	T1H9V9	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.673
MED16	T1HBT0_RHOPR	T1HRI3	T1HBT0	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family.	0.520
MED16	T1HC21_RHOPR	T1HRI3	T1HC21	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	PlsC domain-containing protein.	0.540
MED16	T1HCG0_RHOPR	T1HRI3	T1HCG0	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.479
MED16	T1HCN6_RHOPR	T1HRI3	T1HCN6	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.479
MED16	T1HDI3_RHOPR	T1HRI3	T1HDI3	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	PlsC domain-containing protein.	0.616
MED16	T1HII7_RHOPR	T1HRI3	T1HII7	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.434
MED16	T1HLX5_RHOPR	T1HRI3	T1HLX5	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	0.680
MED16	T1HMB2_RHOPR	T1HRI3	T1HMB2	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	PLD phosphodiesterase domain-containing protein.	0.506