(13 nodes) Non-homologous end-joining network (Rhodnius prolixus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T1I325_RHOPR	Ku domain-containing protein. (582 aa)
	T1I572_RHOPR	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. (513 aa)
	T1I5H0_RHOPR	Uncharacterized protein. (820 aa)
	Fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	T1I7Y7_RHOPR	Ku domain-containing protein. (351 aa)
	R4FMJ7_RHOPR	Putative u2 small nuclear ribonucleoprotein a. (229 aa)
	R4G4E3_RHOPR	Uncharacterized protein. (128 aa)
	T1HCV8_RHOPR	Uncharacterized protein. (358 aa)
	T1HDI7_RHOPR	Lactamase_B domain-containing protein. (270 aa)
	T1HDX0_RHOPR	Uncharacterized protein; Belongs to the ATP-dependent DNA ligase family. (673 aa)
	T1HS80_RHOPR	Zinc-hook domain-containing protein. (1298 aa)
	T1HTC0_RHOPR	NUC194 domain-containing protein. (158 aa)
	T1HZU0_RHOPR	Uncharacterized protein. (229 aa)

Your Current Organism:

Rhodnius prolixus

NCBI taxonomy Id: 13249
Other names: R. prolixus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Fen1	R4G4E3_RHOPR	T1I6X2	R4G4E3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.569
Fen1	T1HDI7_RHOPR	T1I6X2	T1HDI7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Lactamase_B domain-containing protein.	0.416
Fen1	T1HDX0_RHOPR	T1I6X2	T1HDX0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein; Belongs to the ATP-dependent DNA ligase family.	0.850
Fen1	T1HS80_RHOPR	T1I6X2	T1HS80	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Zinc-hook domain-containing protein.	0.975
Fen1	T1I325_RHOPR	T1I6X2	T1I325	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ku domain-containing protein.	0.733
Fen1	T1I572_RHOPR	T1I6X2	T1I572	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family.	0.988
Fen1	T1I7Y7_RHOPR	T1I6X2	T1I7Y7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ku domain-containing protein.	0.569
R4G4E3_RHOPR	Fen1	R4G4E3	T1I6X2	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.569
R4G4E3_RHOPR	T1HCV8_RHOPR	R4G4E3	T1HCV8	Uncharacterized protein.	Uncharacterized protein.	0.523
R4G4E3_RHOPR	T1HDI7_RHOPR	R4G4E3	T1HDI7	Uncharacterized protein.	Lactamase_B domain-containing protein.	0.963
R4G4E3_RHOPR	T1HDX0_RHOPR	R4G4E3	T1HDX0	Uncharacterized protein.	Uncharacterized protein; Belongs to the ATP-dependent DNA ligase family.	0.980
R4G4E3_RHOPR	T1HS80_RHOPR	R4G4E3	T1HS80	Uncharacterized protein.	Zinc-hook domain-containing protein.	0.812
R4G4E3_RHOPR	T1HTC0_RHOPR	R4G4E3	T1HTC0	Uncharacterized protein.	NUC194 domain-containing protein.	0.981
R4G4E3_RHOPR	T1HZU0_RHOPR	R4G4E3	T1HZU0	Uncharacterized protein.	Uncharacterized protein.	0.952
R4G4E3_RHOPR	T1I325_RHOPR	R4G4E3	T1I325	Uncharacterized protein.	Ku domain-containing protein.	0.987
R4G4E3_RHOPR	T1I572_RHOPR	R4G4E3	T1I572	Uncharacterized protein.	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family.	0.971
T1HCV8_RHOPR	R4G4E3_RHOPR	T1HCV8	R4G4E3	Uncharacterized protein.	Uncharacterized protein.	0.523
T1HCV8_RHOPR	T1HDI7_RHOPR	T1HCV8	T1HDI7	Uncharacterized protein.	Lactamase_B domain-containing protein.	0.416
T1HCV8_RHOPR	T1HDX0_RHOPR	T1HCV8	T1HDX0	Uncharacterized protein.	Uncharacterized protein; Belongs to the ATP-dependent DNA ligase family.	0.800
T1HCV8_RHOPR	T1HS80_RHOPR	T1HCV8	T1HS80	Uncharacterized protein.	Zinc-hook domain-containing protein.	0.918