(90 nodes) MAPK signaling pathway - fly network (Rhodnius prolixus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T1IFJ4_RHOPR	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (362 aa)
	T1IF54_RHOPR	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (330 aa)
	T1IFT0_RHOPR	Uncharacterized protein. (668 aa)
	T1IES0_RHOPR	Protein kinase domain-containing protein. (118 aa)
	T1IER8_RHOPR	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (215 aa)
	T1IEI6_RHOPR	Uncharacterized protein. (149 aa)
	T1IEE5_RHOPR	USP domain-containing protein. (265 aa)
	T1ID46_RHOPR	Uncharacterized protein. (739 aa)
	T1ID44_RHOPR	Protein kinase domain-containing protein. (241 aa)
	T1ID21_RHOPR	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (191 aa)
	T1IBT9_RHOPR	Uncharacterized protein. (260 aa)
	T1IBT5_RHOPR	Uncharacterized protein. (660 aa)
	T1IBR6_RHOPR	Uncharacterized protein. (426 aa)
	T1IBR5_RHOPR	Ras-GEF domain-containing protein. (137 aa)
	T1IA05_RHOPR	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (372 aa)
	T1I9M4_RHOPR	Tyrosine-protein kinase. (605 aa)
	T1I5Z9_RHOPR	Uncharacterized protein. (476 aa)
	T1I5X6_RHOPR	ETS domain-containing protein. (202 aa)
	T1I5A2_RHOPR	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
	T1I4F0_RHOPR	Uncharacterized protein. (1230 aa)
	T1I409_RHOPR	Uncharacterized protein. (380 aa)
	T1I3X2_RHOPR	Tyrosine-protein kinase Ksr. (918 aa)
	T1I328_RHOPR	Uncharacterized protein. (107 aa)
	T1I2V6_RHOPR	NR LBD domain-containing protein. (195 aa)
	T1I2S2_RHOPR	Uncharacterized protein. (102 aa)
	T1I1G4_RHOPR	Tyrosine-protein kinase. (501 aa)
	T1I0D5_RHOPR	Uncharacterized protein. (345 aa)
	T1HZY5_RHOPR	PPM-type phosphatase domain-containing protein. (366 aa)
	T1HZB6_RHOPR	Spitz. Epidermal Growth factor ligand. (136 aa)
	T1HZ01_RHOPR	Prospero domain-containing protein. (156 aa)
	T1HXT4_RHOPR	Uncharacterized protein. (60 aa)
	T1HXT3_RHOPR	Uncharacterized protein. (116 aa)
	T1HXL4_RHOPR	Mitogen-activated protein kinase kinase kinase. (538 aa)
	T1HWY3_RHOPR	Uncharacterized protein. (189 aa)
	T1HWP2_RHOPR	Uncharacterized protein. (710 aa)
	T1HWM7_RHOPR	PH domain-containing protein. (72 aa)
	T1HWF6_RHOPR	Uncharacterized protein. (145 aa)
	T1HWB6_RHOPR	Tyrosine-protein kinase. (534 aa)
	T1HU71_RHOPR	Mitogen-activated protein kinase. (389 aa)
	T1HT97_RHOPR	Uncharacterized protein. (68 aa)
	T1HSZ9_RHOPR	Uncharacterized protein. (219 aa)
	T1HSK5_RHOPR	Uncharacterized protein. (370 aa)
	T1HSJ7_RHOPR	PH domain-containing protein. (194 aa)
	T1HSJ5_RHOPR	Rhodanese domain-containing protein. (199 aa)
	T1HSD0_RHOPR	Uncharacterized protein. (412 aa)
	T1HSC1_RHOPR	Uncharacterized protein. (1286 aa)
	T1HS40_RHOPR	Receptor protein-tyrosine kinase. (1206 aa)
	T1HRR6_RHOPR	Uncharacterized protein. (378 aa)
	T1HR43_RHOPR	Uncharacterized protein. (362 aa)
	T1HR36_RHOPR	Uncharacterized protein. (163 aa)
	T1HQT4_RHOPR	N-terminal Ras-GEF domain-containing protein. (306 aa)
	T1HQ26_RHOPR	Uncharacterized protein. (729 aa)
	T1HP78_RHOPR	Uncharacterized protein. (189 aa)
	T1HP26_RHOPR	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (226 aa)
	T1HP17_RHOPR	Uncharacterized protein. (499 aa)
	T1HNZ4_RHOPR	Uncharacterized protein. (794 aa)
	T1HMW7_RHOPR	Runt domain-containing protein. (151 aa)
	T1HM83_RHOPR	Uncharacterized protein. (928 aa)
	T1HLF9_RHOPR	Dual oxidase. (1450 aa)
	T1HKF7_RHOPR	TNFR-Cys domain-containing protein. (497 aa)
	T1HKB0_RHOPR	Uncharacterized protein. (771 aa)
	T1HJK8_RHOPR	Raf homolog kinase phl. (686 aa)
	T1HJC7_RHOPR	Protein kinase domain-containing protein. (1053 aa)
	T1HHL8_RHOPR	BZIP domain-containing protein. (274 aa)
	T1HFU2_RHOPR	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (373 aa)
	T1HFN4_RHOPR	Ig-like domain-containing protein. (593 aa)
	T1HEU9_RHOPR	Uncharacterized protein. (222 aa)
	T1HD54_RHOPR	Ras-GEF domain-containing protein. (424 aa)
	T1HD03_RHOPR	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (294 aa)
	T1HCK5_RHOPR	WD_REPEATS_REGION domain-containing protein. (388 aa)
	T1HBP5_RHOPR	Importin N-terminal domain-containing protein. (544 aa)
	T1HBI4_RHOPR	Ig-like domain-containing protein. (741 aa)
	T1HBC6_RHOPR	MADS-box domain-containing protein. (264 aa)
	T1HB35_RHOPR	Tyrosine-protein kinase receptor. (2263 aa)
	T1HAR3_RHOPR	Protein kinase domain-containing protein. (796 aa)
	T1HAN5_RHOPR	HMG box domain-containing protein. (1884 aa)
	T1HAL6_RHOPR	Uncharacterized protein. (971 aa)
	T1HA38_RHOPR	Uncharacterized protein. (222 aa)
	T1H9W6_RHOPR	Uncharacterized protein. (495 aa)
	T1H8Q4_RHOPR	Decapentaplegic BMP ligand. (356 aa)
	T1H7T3_RHOPR	Uncharacterized protein. (236 aa)
	T1H7P8_RHOPR	Runt domain-containing protein. (145 aa)
	R4G8Q4_RHOPR	Serine/threonine-protein phosphatase. (309 aa)
	R4G8D4_RHOPR	Putative transcriptional activator of the jun family. (251 aa)
	R4G5D9_RHOPR	Putative 14-3-3-like protein; Belongs to the 14-3-3 family. (247 aa)
	R4G578_RHOPR	Putative ras-related protein rac1 isoform 1. (192 aa)
	R4G508_RHOPR	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa)
	R4G4C2_RHOPR	Mitogen-activated protein kinase. (358 aa)
	R4FJZ0_RHOPR	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (218 aa)
	R4FJV5_RHOPR	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (336 aa)

Your Current Organism:

Rhodnius prolixus

NCBI taxonomy Id: 13249
Other names: R. prolixus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
R4FJV5_RHOPR	T1HP17_RHOPR	R4FJV5	T1HP17	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	Uncharacterized protein.	0.945
R4FJV5_RHOPR	T1IBT5_RHOPR	R4FJV5	T1IBT5	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	Uncharacterized protein.	0.914
R4FJZ0_RHOPR	T1HU71_RHOPR	R4FJZ0	T1HU71	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	Mitogen-activated protein kinase.	0.908
R4G4C2_RHOPR	R4G578_RHOPR	R4G4C2	R4G578	Mitogen-activated protein kinase.	Putative ras-related protein rac1 isoform 1.	0.756
R4G4C2_RHOPR	R4G5D9_RHOPR	R4G4C2	R4G5D9	Mitogen-activated protein kinase.	Putative 14-3-3-like protein; Belongs to the 14-3-3 family.	0.748
R4G4C2_RHOPR	R4G8D4_RHOPR	R4G4C2	R4G8D4	Mitogen-activated protein kinase.	Putative transcriptional activator of the jun family.	0.935
R4G4C2_RHOPR	R4G8Q4_RHOPR	R4G4C2	R4G8Q4	Mitogen-activated protein kinase.	Serine/threonine-protein phosphatase.	0.851
R4G4C2_RHOPR	T1HAR3_RHOPR	R4G4C2	T1HAR3	Mitogen-activated protein kinase.	Protein kinase domain-containing protein.	0.821
R4G4C2_RHOPR	T1HB35_RHOPR	R4G4C2	T1HB35	Mitogen-activated protein kinase.	Tyrosine-protein kinase receptor.	0.603
R4G4C2_RHOPR	T1HBC6_RHOPR	R4G4C2	T1HBC6	Mitogen-activated protein kinase.	MADS-box domain-containing protein.	0.995
R4G4C2_RHOPR	T1HBP5_RHOPR	R4G4C2	T1HBP5	Mitogen-activated protein kinase.	Importin N-terminal domain-containing protein.	0.727
R4G4C2_RHOPR	T1HD03_RHOPR	R4G4C2	T1HD03	Mitogen-activated protein kinase.	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.974
R4G4C2_RHOPR	T1HFU2_RHOPR	R4G4C2	T1HFU2	Mitogen-activated protein kinase.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.988
R4G4C2_RHOPR	T1HHL8_RHOPR	R4G4C2	T1HHL8	Mitogen-activated protein kinase.	BZIP domain-containing protein.	0.976
R4G4C2_RHOPR	T1HJC7_RHOPR	R4G4C2	T1HJC7	Mitogen-activated protein kinase.	Protein kinase domain-containing protein.	0.766
R4G4C2_RHOPR	T1HJK8_RHOPR	R4G4C2	T1HJK8	Mitogen-activated protein kinase.	Raf homolog kinase phl.	0.870
R4G4C2_RHOPR	T1HKB0_RHOPR	R4G4C2	T1HKB0	Mitogen-activated protein kinase.	Uncharacterized protein.	0.873
R4G4C2_RHOPR	T1HLF9_RHOPR	R4G4C2	T1HLF9	Mitogen-activated protein kinase.	Dual oxidase.	0.772
R4G4C2_RHOPR	T1HP78_RHOPR	R4G4C2	T1HP78	Mitogen-activated protein kinase.	Uncharacterized protein.	0.756
R4G4C2_RHOPR	T1HS40_RHOPR	R4G4C2	T1HS40	Mitogen-activated protein kinase.	Receptor protein-tyrosine kinase.	0.441