STRINGSTRING
metK metK luxS luxS mtnD mtnD mtnB mtnB mtnX mtnX mtnW mtnW GCA_001418025_00395 GCA_001418025_00395 mtnK mtnK mtnA mtnA GCA_001418025_00458 GCA_001418025_00458 GCA_001418025_00459 GCA_001418025_00459 GCA_001418025_00646 GCA_001418025_00646 GCA_001418025_00647 GCA_001418025_00647 GCA_001418025_01685 GCA_001418025_01685 cysI cysI GCA_001418025_01743 GCA_001418025_01743 GCA_001418025_01827 GCA_001418025_01827 metAA metAA GCA_001418025_02306 GCA_001418025_02306 Ga0061060_1213 Ga0061060_1213 Ga0061060_1214 Ga0061060_1214 mtnN mtnN Ga0061060_1216 Ga0061060_1216 GCA_001418025_02491 GCA_001418025_02491 metE metE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
metKUnannotated protein; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (401 aa)
luxSUnannotated protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (157 aa)
mtnDUnannotated protein; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (178 aa)
mtnBUnannotated protein; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). (202 aa)
mtnXUnannotated protein; Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). (218 aa)
mtnWUnannotated protein; Catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphate (HK-MTPenyl-1-P); Belongs to the RuBisCO large chain family. Type IV subfamily. (407 aa)
GCA_001418025_00395Unannotated protein. (390 aa)
mtnKUnannotated protein; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (389 aa)
mtnAUnannotated protein; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (344 aa)
GCA_001418025_00458Unannotated protein. (379 aa)
GCA_001418025_00459Unannotated protein. (367 aa)
GCA_001418025_00646Unannotated protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1129 aa)
GCA_001418025_00647Unannotated protein. (615 aa)
GCA_001418025_01685Unannotated protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (305 aa)
cysIUnannotated protein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (571 aa)
GCA_001418025_01743Unannotated protein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (590 aa)
GCA_001418025_01827Unannotated protein. (430 aa)
metAAUnannotated protein; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (302 aa)
GCA_001418025_02306Unannotated protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (308 aa)
Ga0061060_1213Unannotated protein. (377 aa)
Ga0061060_1214Unannotated protein. (307 aa)
mtnNUnannotated protein; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (232 aa)
Ga0061060_1216Unannotated protein; Could be a S-adenosyl-L-methionine-dependent methyltransferase. (212 aa)
GCA_001418025_02491Unannotated protein. (221 aa)
metEUnannotated protein; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (757 aa)
Your Current Organism:
Anoxybacillus suryakundensis
NCBI taxonomy Id: 1325335
Other names: A. suryakundensis, Anoxybacillus sp. JS1, Anoxybacillus sp. JS11, Anoxybacillus sp. JS15, Anoxybacillus sp. JS5, DSM 27374, JCM19211, LMG 27616, LMG:27616, strain JS1
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