STRINGSTRING
L486_03328 L486_03328 L486_02016 L486_02016 L486_01875 L486_01875 L486_01784 L486_01784 L486_01742 L486_01742 L486_01550 L486_01550 L486_01462 L486_01462 L486_01356 L486_01356 L486_01324 L486_01324 L486_00951 L486_00951 L486_00916 L486_00916 L486_00888 L486_00888 L486_00753 L486_00753 L486_00394 L486_00394 L486_00418 L486_00418 SLX1 SLX1 L486_00396 L486_00396 KAE1 KAE1 L486_00337 L486_00337 L486_00106 L486_00106 L486_02921 L486_02921 L486_02765 L486_02765 L486_02577 L486_02577 L486_02487 L486_02487 L486_02551 L486_02551 L486_02519 L486_02519 L486_02435 L486_02435 L486_02384 L486_02384 L486_02314 L486_02314 L486_02298 L486_02298 L486_02231 L486_02231 L486_02059 L486_02059 L486_02061 L486_02061 L486_03662 L486_03662 L486_03602 L486_03602 FEN1 FEN1 L486_04585 L486_04585 L486_04337 L486_04337 L486_04050 L486_04050 L486_04062 L486_04062 L486_04018 L486_04018 L486_03966 L486_03966 L486_05153 L486_05153 L486_05238 L486_05238 L486_04987 L486_04987 L486_04839 L486_04839 L486_04706 L486_04706 L486_04836 L486_04836 L486_04625 L486_04625 L486_05959 L486_05959 L486_04632 L486_04632 L486_05994 L486_05994 L486_05774 L486_05774 L486_05677 L486_05677 L486_05630 L486_05630 L486_05583 L486_05583 L486_05357 L486_05357 L486_06225 L486_06225 L486_06211 L486_06211 L486_06214 L486_06214 L486_06697 L486_06697 MCM7 MCM7 L486_06674 L486_06674 L486_06435 L486_06435 L486_06610 L486_06610 L486_06675 L486_06675 L486_07078 L486_07078 L486_07128 L486_07128 L486_06538 L486_06538 L486_07077 L486_07077 L486_07051 L486_07051 L486_06991 L486_06991 L486_07373 L486_07373 L486_07272 L486_07272 L486_07365 L486_07365 L486_07382 L486_07382 L486_07663 L486_07663 L486_07200 L486_07200 L486_07664 L486_07664 L486_07595 L486_07595 L486_07803 L486_07803 L486_07706 L486_07706 L486_07902 L486_07902 L486_08084 L486_08084 L486_07882 L486_07882 L486_08088 L486_08088 L486_08249 L486_08249 L486_08418 L486_08418
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
L486_03328DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (973 aa)
L486_02016SMC_N domain-containing protein. (1187 aa)
L486_01875Uncharacterized protein. (996 aa)
L486_01784Meiotic Sister-Chromatid recombination aldehyde dehydrogenase. (632 aa)
L486_01742RING-type domain-containing protein. (459 aa)
L486_01550DNA_LIGASE_A3 domain-containing protein. (933 aa)
L486_01462Cell division control protein 45. (727 aa)
L486_01356Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (388 aa)
L486_01324DNA repair protein Swi5/Sae3. (107 aa)
L486_00951DNA ligase. (817 aa)
L486_00916Ku domain-containing protein. (753 aa)
L486_00888Mitochondrial genome maintenance protein. (329 aa)
L486_00753Uncharacterized protein. (985 aa)
L486_00394DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1492 aa)
L486_00418DNA_MISMATCH_REPAIR_2 domain-containing protein. (821 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (435 aa)
L486_00396Rad51 domain-containing protein. (411 aa)
KAE1tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (380 aa)
L486_00337Deacetylase sirtuin-type domain-containing protein. (591 aa)
L486_00106AAA domain-containing protein. (1051 aa)
L486_02921DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1129 aa)
L486_02765Serine/threonine-protein phosphatase. (308 aa)
L486_02577PLK/PLK1 protein kinase. (773 aa)
L486_02487Uncharacterized protein. (358 aa)
L486_02551Checkpoint protein; Belongs to the HUS1 family. (307 aa)
L486_02519Helicase. (859 aa)
L486_02435RECA_2 domain-containing protein. (590 aa)
L486_02384TBPIP domain-containing protein. (283 aa)
L486_02314DNA ligase. (1078 aa)
L486_02298AAA domain-containing protein; Belongs to the AAA ATPase family. (560 aa)
L486_02231ERCC4 domain-containing protein. (598 aa)
L486_02059Uncharacterized protein. (370 aa)
L486_02061Meiotic nuclear division protein 1; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (171 aa)
L486_03662Uncharacterized protein. (346 aa)
L486_03602Uncharacterized protein. (635 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (439 aa)
L486_04585DNA mismatch repair protein MSH2; Component of the post-replicative DNA mismatch repair system (MMR). (973 aa)
L486_04337DNA excision repair protein ERCC-4. (1129 aa)
L486_04050DNA ligase 1. (1005 aa)
L486_04062Uncharacterized protein. (307 aa)
L486_04018Uncharacterized protein. (719 aa)
L486_03966DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1202 aa)
L486_05153DNA replication complex GINS protein PSF1. (228 aa)
L486_05238DNA helicase; Belongs to the MCM family. (929 aa)
L486_04987DUF1767 domain-containing protein. (565 aa)
L486_04839DNA mismatch repair protein MLH1. (761 aa)
L486_04706Endonuclease. (369 aa)
L486_04836Deacetylase sirtuin-type domain-containing protein. (474 aa)
L486_04625DNA helicase; Belongs to the MCM family. (874 aa)
L486_05959Replication factor A2. (279 aa)
L486_04632Uncharacterized protein. (1321 aa)
L486_05994SMC_N domain-containing protein. (1172 aa)
L486_05774WD_REPEATS_REGION domain-containing protein. (1288 aa)
L486_05677DNA repair protein RAD50. (1360 aa)
L486_0563026S proteasome complex subunit DSS1. (107 aa)
L486_05583Uncharacterized protein. (185 aa)
L486_05357Uncharacterized protein; Belongs to the CGI121/TPRKB family. (226 aa)
L486_06225DNA excision repair protein ERCC-1. (384 aa)
L486_06211Uncharacterized protein. (1474 aa)
L486_06214DNA helicase; Belongs to the MCM family. (998 aa)
L486_06697DNA helicase; Belongs to the MCM family. (755 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (797 aa)
L486_066743'-5' exonuclease domain-containing protein. (354 aa)
L486_06435DNA polymerase. (1969 aa)
L486_06610DNA helicase; Belongs to the MCM family. (965 aa)
L486_066753'-5' exonuclease domain-containing protein. (643 aa)
L486_07078Uncharacterized protein. (76 aa)
L486_07128Rad51 domain-containing protein. (369 aa)
L486_06538ERCC4 domain-containing protein. (836 aa)
L486_07077Uncharacterized protein. (1173 aa)
L486_07051DNA repair and recombination protein RAD54B. (1082 aa)
L486_06991DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (194 aa)
L486_07373Ku domain-containing protein. (865 aa)
L486_07272Uncharacterized protein. (549 aa)
L486_07365Uncharacterized protein. (879 aa)
L486_07382ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (956 aa)
L486_07663SP-RING-type domain-containing protein. (311 aa)
L486_07200Uncharacterized protein. (841 aa)
L486_07664Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (613 aa)
L486_07595DNA repair and recombination protein RAD54-like protein. (817 aa)
L486_07803DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (344 aa)
L486_07706Meiotic recombinase Dmc1; Belongs to the RecA family. (350 aa)
L486_07902DUF3421 domain-containing protein. (398 aa)
L486_08084SWIM-type domain-containing protein. (239 aa)
L486_07882CDC7 protein kinase. (915 aa)
L486_08088Uncharacterized protein. (618 aa)
L486_08249Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa)
L486_08418TP6A_N domain-containing protein. (755 aa)
Your Current Organism:
Kwoniella mangroviensis
NCBI taxonomy Id: 1331196
Other names: K. mangroviensis CBS 10435, Kwoniella mangroviensis CBS 10435, Kwoniella mangroviensis CBS10435
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