Your Input: | |||||
L486_03328 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (973 aa) | ||||
L486_08344 | Chromo domain-containing protein. (908 aa) | ||||
L486_08316 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (554 aa) | ||||
L486_08396 | Uncharacterized protein. (1166 aa) | ||||
L486_08203 | HABP4_PAI-RBP1 domain-containing protein. (375 aa) | ||||
L486_08213 | CBFD_NFYB_HMF domain-containing protein. (212 aa) | ||||
L486_08169 | Nuclear DNA helicase II. (1611 aa) | ||||
L486_08217 | Uncharacterized protein. (881 aa) | ||||
L486_08378 | Uncharacterized protein. (357 aa) | ||||
L486_08325 | Zf-rbx1 domain-containing protein. (91 aa) | ||||
L486_08357 | Chromo domain-containing protein. (658 aa) | ||||
L486_07974 | TTK protein kinase. (895 aa) | ||||
L486_08397 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (358 aa) | ||||
L486_08109 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (749 aa) | ||||
L486_08001 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (507 aa) | ||||
L486_07960 | Uncharacterized protein. (173 aa) | ||||
L486_07760 | Uncharacterized protein. (894 aa) | ||||
PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (717 aa) | ||||
L486_07780 | ATP-dependent helicase. (1054 aa) | ||||
L486_07801 | Chromatin assembly factor 1 subunit B. (833 aa) | ||||
L486_07822 | RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. (451 aa) | ||||
L486_08092 | Anaphase-promoting complex subunit 10. (237 aa) | ||||
L486_07787 | Compass component swd1. (482 aa) | ||||
L486_07902 | DUF3421 domain-containing protein. (398 aa) | ||||
L486_07706 | Meiotic recombinase Dmc1; Belongs to the RecA family. (350 aa) | ||||
L486_07803 | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (344 aa) | ||||
L486_07887 | Condensin complex subunit 3. (1013 aa) | ||||
L486_07886 | Kinetochore protein Nuf2. (452 aa) | ||||
L486_07585 | Cytoplasmic protein. (378 aa) | ||||
L486_07898 | TFIIH basal transcription factor complex TTD-A subunit. (81 aa) | ||||
L486_07595 | DNA repair and recombination protein RAD54-like protein. (817 aa) | ||||
L486_07752 | SWR1-complex protein 4. (462 aa) | ||||
L486_07488 | Uncharacterized protein. (1430 aa) | ||||
L486_07664 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (613 aa) | ||||
L486_07900 | Uncharacterized protein. (793 aa) | ||||
L486_07209 | Histone H2B; Belongs to the histone H2B family. (139 aa) | ||||
L486_07926 | DNA excision repair protein ERCC-3. (876 aa) | ||||
L486_07570 | Structural maintenance of chromosomes protein. (1306 aa) | ||||
L486_07576 | CBFD_NFYB_HMF domain-containing protein. (138 aa) | ||||
L486_07382 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (956 aa) | ||||
L486_07212 | RFX-type winged-helix domain-containing protein. (753 aa) | ||||
L486_07395 | Uncharacterized protein. (483 aa) | ||||
L486_07310 | Uncharacterized protein. (1365 aa) | ||||
L486_06922 | FACT complex subunit SPT16. (1045 aa) | ||||
L486_07447 | Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (784 aa) | ||||
L486_07327 | Uncharacterized protein. (1210 aa) | ||||
L486_07373 | Ku domain-containing protein. (865 aa) | ||||
L486_07043 | HRDC domain-containing protein. (969 aa) | ||||
L486_07439 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (317 aa) | ||||
L486_06429 | Bromo domain-containing protein. (833 aa) | ||||
L486_06961 | Uncharacterized protein. (470 aa) | ||||
L486_06457 | SUN domain-containing protein. (911 aa) | ||||
L486_07051 | DNA repair and recombination protein RAD54B. (1082 aa) | ||||
L486_07077 | Uncharacterized protein. (1173 aa) | ||||
L486_06984 | SET domain-containing protein. (1404 aa) | ||||
L486_07078 | Uncharacterized protein. (76 aa) | ||||
L486_06585 | Transcription elongation factor SPT6. (1560 aa) | ||||
L486_06610 | DNA helicase; Belongs to the MCM family. (965 aa) | ||||
L486_06755 | SHNi-TPR domain-containing protein. (475 aa) | ||||
L486_06580 | Sua5/YciO/YrdC/YwlC family protein. (492 aa) | ||||
L486_06472 | Structural maintenance of chromosomes protein. (1246 aa) | ||||
L486_06451 | HTH APSES-type domain-containing protein. (398 aa) | ||||
L486_06623 | GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (274 aa) | ||||
L486_06704 | RP/EB family microtubule-associated protein. (253 aa) | ||||
L486_06690 | Uncharacterized protein. (369 aa) | ||||
L486_06688 | Chromosome transmission fidelity protein 1. (891 aa) | ||||
L486_06670 | Brg1-associated factor b; Belongs to the actin family. (474 aa) | ||||
MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (797 aa) | ||||
L486_06697 | DNA helicase; Belongs to the MCM family. (755 aa) | ||||
L486_06163 | mRNA export factor. (360 aa) | ||||
L486_06041 | Mortality factor 4-like protein 1. (313 aa) | ||||
L486_06223 | Uncharacterized protein. (225 aa) | ||||
L486_06208 | Spc7 domain-containing protein. (1096 aa) | ||||
L486_06214 | DNA helicase; Belongs to the MCM family. (998 aa) | ||||
L486_06393 | Uncharacterized protein. (346 aa) | ||||
L486_06211 | Uncharacterized protein. (1474 aa) | ||||
L486_05334 | Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (921 aa) | ||||
L486_06361 | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (3049 aa) | ||||
L486_05342 | Uncharacterized protein. (717 aa) | ||||
L486_05375 | Uncharacterized protein. (577 aa) | ||||
L486_05392 | Uncharacterized protein. (307 aa) | ||||
L486_05357 | Uncharacterized protein; Belongs to the CGI121/TPRKB family. (226 aa) | ||||
L486_05583 | Uncharacterized protein. (185 aa) | ||||
L486_05603 | PHD-type domain-containing protein. (1125 aa) | ||||
L486_05495 | Uncharacterized protein. (734 aa) | ||||
L486_05677 | DNA repair protein RAD50. (1360 aa) | ||||
L486_05718 | Uncharacterized protein. (721 aa) | ||||
L486_05805 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (620 aa) | ||||
L486_05763 | WD_REPEATS_REGION domain-containing protein. (429 aa) | ||||
L486_05604 | Compass component swd2. (428 aa) | ||||
L486_05615 | Uncharacterized protein. (559 aa) | ||||
L486_05883 | Uncharacterized protein. (645 aa) | ||||
L486_05685 | INCENP_ARK-bind domain-containing protein. (1234 aa) | ||||
L486_05889 | Uncharacterized protein. (1073 aa) | ||||
L486_05907 | Sister chromatid cohesion protein DCC1. (414 aa) | ||||
L486_05709 | Uncharacterized protein. (111 aa) | ||||
L486_05945 | Helicase C-terminal domain-containing protein. (912 aa) | ||||
L486_05951 | Chromatin modification-related protein. (350 aa) | ||||
L486_05971 | Helicase ATP-binding domain-containing protein. (891 aa) | ||||
L486_04602 | RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. (489 aa) | ||||
L486_04654 | B30.2/SPRY domain-containing protein. (657 aa) | ||||
L486_04675 | RNA polymerase II-associated factor 1. (453 aa) | ||||
L486_04632 | Uncharacterized protein. (1321 aa) | ||||
L486_05877 | JmjC domain-containing protein. (425 aa) | ||||
L486_04674 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2240 aa) | ||||
L486_04625 | DNA helicase; Belongs to the MCM family. (874 aa) | ||||
L486_04789 | Uncharacterized protein. (693 aa) | ||||
L486_04799 | Uncharacterized protein. (733 aa) | ||||
L486_04836 | Deacetylase sirtuin-type domain-containing protein. (474 aa) | ||||
L486_04846 | TATA-binding protein-associated factor. (1880 aa) | ||||
L486_04757 | DNA replication ATP-dependent helicase Dna2. (1348 aa) | ||||
L486_04860 | Nucleosome assembly protein 1-like 1; Belongs to the nucleosome assembly protein (NAP) family. (424 aa) | ||||
L486_04750 | DNA polymerase eta subunit. (743 aa) | ||||
L486_04934 | Uncharacterized protein. (438 aa) | ||||
L486_04944 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (265 aa) | ||||
L486_04915 | Transcriptional activator SPT8. (742 aa) | ||||
L486_04994 | Chromatin modification-related protein. (540 aa) | ||||
L486_04997 | RNA-dependent RNA polymerase. (882 aa) | ||||
L486_04996 | Uncharacterized protein. (222 aa) | ||||
EFM7 | Protein N-terminal and lysine N-methyltransferase EFM7; S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono-and dimethylation of 'Lys-3'. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family. (296 aa) | ||||
L486_04898 | Anaphase-promoting complex subunit 6. (880 aa) | ||||
L486_05062 | PHD-type domain-containing protein. (917 aa) | ||||
L486_05107 | Uncharacterized protein. (680 aa) | ||||
L486_05183 | JmjC domain-containing protein. (789 aa) | ||||
L486_05214 | DNA repair protein. (329 aa) | ||||
L486_05208 | Chromo domain-containing protein. (243 aa) | ||||
L486_05094 | Uncharacterized protein. (263 aa) | ||||
L486_05238 | DNA helicase; Belongs to the MCM family. (929 aa) | ||||
L486_05222 | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1207 aa) | ||||
L486_05153 | DNA replication complex GINS protein PSF1. (228 aa) | ||||
L486_05252 | Uncharacterized protein. (477 aa) | ||||
L486_05291 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1130 aa) | ||||
L486_05292 | Zinc finger HIT domain-containing protein 1. (169 aa) | ||||
L486_03912 | DNA helicase II/ATP-dependent DNA helicase PcrA. (1078 aa) | ||||
L486_03934 | H15 domain-containing protein. (134 aa) | ||||
L486_03946 | Uncharacterized protein. (884 aa) | ||||
L486_03918 | Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (446 aa) | ||||
L486_03933 | Histone deacetylase 6/10. (861 aa) | ||||
L486_03991 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (740 aa) | ||||
L486_04015 | Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (289 aa) | ||||
L486_04062 | Uncharacterized protein. (307 aa) | ||||
L486_04038 | Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. (608 aa) | ||||
L486_04084 | Acetyltransf_13 domain-containing protein. (454 aa) | ||||
L486_04089 | Uncharacterized protein. (1144 aa) | ||||
L486_04011 | Uncharacterized protein. (1339 aa) | ||||
L486_04057 | DNA excision repair protein ERCC-2. (806 aa) | ||||
L486_04078 | Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (423 aa) | ||||
L486_04103 | Cleft lip and palate associated transmembrane protein. (616 aa) | ||||
L486_04316 | Uncharacterized protein. (1646 aa) | ||||
L486_04347 | Transcription activator snf2l1. (1095 aa) | ||||
L486_04354 | BCNT-C domain-containing protein. (286 aa) | ||||
L486_04351 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (478 aa) | ||||
L486_04459 | Cohesin complex subunit SA-1/2. (1359 aa) | ||||
L486_04559 | Uncharacterized protein. (1769 aa) | ||||
L486_04585 | DNA mismatch repair protein MSH2; Component of the post-replicative DNA mismatch repair system (MMR). (973 aa) | ||||
L486_04457 | Ubiquitin-conjugating enzyme E2 2; Belongs to the ubiquitin-conjugating enzyme family. (182 aa) | ||||
L486_03108 | Uncharacterized protein. (1660 aa) | ||||
L486_03105 | NAD-dependent histone deacetylase SIR2. (565 aa) | ||||
L486_03263 | Uncharacterized protein. (614 aa) | ||||
L486_03269 | 26S protease regulatory subunit 8; Belongs to the AAA ATPase family. (407 aa) | ||||
L486_03277 | Uncharacterized protein. (1262 aa) | ||||
L486_03315 | COP9 signalosome complex subunit 12. (403 aa) | ||||
L486_03354 | Uncharacterized protein. (496 aa) | ||||
L486_03373 | PAPA-1 domain-containing protein. (413 aa) | ||||
L486_03367 | Poly(RC)-binding protein 2/3/4. (394 aa) | ||||
L486_03368 | Uncharacterized protein. (1067 aa) | ||||
L486_03274 | Actin-like protein ARP6; Belongs to the actin family. (464 aa) | ||||
L486_03435 | Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (140 aa) | ||||
L486_03468 | Beta-lactamase domain-containing protein. (299 aa) | ||||
L486_03509 | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (898 aa) | ||||
L486_03549 | Nuclear pore complex protein Nup155. (1331 aa) | ||||
FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (439 aa) | ||||
L486_03577 | Uncharacterized protein. (1981 aa) | ||||
L486_03560 | E3 ubiquitin-protein ligase SHPRH. (1660 aa) | ||||
L486_03602 | Uncharacterized protein. (635 aa) | ||||
L486_03618 | Uncharacterized protein. (526 aa) | ||||
SUS1 | Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex required for deubiquitination of [...] (100 aa) | ||||
L486_03631 | ATPase. (572 aa) | ||||
L486_03704 | Uncharacterized protein. (1702 aa) | ||||
L486_03802 | CUE domain-containing protein. (934 aa) | ||||
L486_03696 | Uncharacterized protein. (492 aa) | ||||
L486_02077 | CENP-C_C domain-containing protein. (724 aa) | ||||
L486_02049 | Anaphase-promoting complex subunit 8. (596 aa) | ||||
L486_02152 | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (648 aa) | ||||
L486_02184 | Chromatin modification-related protein. (485 aa) | ||||
L486_02222 | DNA repair protein Rad8. (2472 aa) | ||||
L486_02241 | Uncharacterized protein. (665 aa) | ||||
L486_02310 | HORMA domain-containing protein. (926 aa) | ||||
L486_02325 | Uncharacterized protein. (641 aa) | ||||
L486_02343 | 26S proteasome regulatory subunit N7. (382 aa) | ||||
L486_02221 | Uncharacterized protein. (804 aa) | ||||
L486_02234 | Transcription initiation factor TFIID subunit 9B. (214 aa) | ||||
L486_02384 | TBPIP domain-containing protein. (283 aa) | ||||
L486_02405 | ATP-dependent helicase STH1/SNF2. (1540 aa) | ||||
L486_02419 | Uncharacterized protein. (653 aa) | ||||
L486_02366 | Uncharacterized protein; Belongs to the actin family. (745 aa) | ||||
L486_02495 | Histone H2A; Belongs to the histone H2A family. (139 aa) | ||||
L486_02519 | Helicase. (859 aa) | ||||
L486_02526 | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1412 aa) | ||||
L486_02544 | Uncharacterized protein. (1003 aa) | ||||
L486_02551 | Checkpoint protein; Belongs to the HUS1 family. (307 aa) | ||||
L486_02594 | Bromodomain-containing factor 1. (906 aa) | ||||
L486_02628 | General transcriptional repressor. (1155 aa) | ||||
L486_02664 | Histone deacetylase 1/2. (626 aa) | ||||
L486_02680 | Uncharacterized protein. (1558 aa) | ||||
L486_02577 | PLK/PLK1 protein kinase. (773 aa) | ||||
L486_02671 | C2H2-type domain-containing protein. (845 aa) | ||||
L486_02721 | SET domain-containing protein. (452 aa) | ||||
L486_02783 | Uncharacterized protein. (684 aa) | ||||
L486_02826 | TYR_PHOSPHATASE_2 domain-containing protein. (747 aa) | ||||
L486_02833 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) | ||||
L486_02867 | Sister chromatid cohesion protein. (1959 aa) | ||||
L486_02915 | FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (584 aa) | ||||
L486_02824 | Uncharacterized protein. (183 aa) | ||||
L486_03031 | Uncharacterized protein. (307 aa) | ||||
L486_00074 | Histone chaperone ASF1. (293 aa) | ||||
L486_00106 | AAA domain-containing protein. (1051 aa) | ||||
L486_00139 | DNA repair protein RAD5. (1197 aa) | ||||
L486_00148 | INO80 complex subunit C. (264 aa) | ||||
L486_00182 | Uncharacterized protein. (476 aa) | ||||
L486_00244 | Kinesin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1045 aa) | ||||
L486_00157 | Uncharacterized protein. (1130 aa) | ||||
L486_00323 | Histone acetyltransferase. (913 aa) | ||||
L486_00337 | Deacetylase sirtuin-type domain-containing protein. (591 aa) | ||||
L486_00219 | ARID domain-containing protein. (1199 aa) | ||||
L486_00318 | Uncharacterized protein. (765 aa) | ||||
KAE1 | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (380 aa) | ||||
L486_00239 | Uncharacterized protein. (481 aa) | ||||
L486_00396 | Rad51 domain-containing protein. (411 aa) | ||||
L486_00409 | tRNA dimethylallyltransferase. (553 aa) | ||||
L486_00407 | JmjC domain-containing protein. (280 aa) | ||||
L486_00394 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1492 aa) | ||||
L486_00589 | DNA helicase. (754 aa) | ||||
L486_00528 | Uncharacterized protein. (1933 aa) | ||||
L486_00661 | Uncharacterized protein. (234 aa) | ||||
L486_00675 | Hist_deacetyl domain-containing protein. (464 aa) | ||||
L486_00687 | FK506-binding protein. (430 aa) | ||||
L486_00618 | Uncharacterized protein. (933 aa) | ||||
L486_00753 | Uncharacterized protein. (985 aa) | ||||
L486_00668 | zf-GRF domain-containing protein. (265 aa) | ||||
L486_00766 | Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (872 aa) | ||||
L486_00821 | Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. (115 aa) | ||||
L486_00887 | Uncharacterized protein. (389 aa) | ||||
L486_00916 | Ku domain-containing protein. (753 aa) | ||||
L486_00969 | Telomere_reg-2 domain-containing protein. (1068 aa) | ||||
L486_00850 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (905 aa) | ||||
L486_00978 | E3 ubiquitin protein ligase. (840 aa) | ||||
L486_00911 | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (801 aa) | ||||
L486_01055 | Chromodomain-helicase-DNA-binding protein 1. (1562 aa) | ||||
L486_01069 | Uncharacterized protein. (676 aa) | ||||
L486_01138 | Structural maintenance of chromosomes protein. (1220 aa) | ||||
L486_01157 | CULLIN_2 domain-containing protein; Belongs to the cullin family. (814 aa) | ||||
L486_01176 | NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (413 aa) | ||||
L486_01222 | Uncharacterized protein. (762 aa) | ||||
L486_01246 | DNA polymerase epsilon p12 subunit. (335 aa) | ||||
L486_01231 | SCA7 domain-containing protein. (461 aa) | ||||
L486_01298 | ATP-dependent DNA helicase; Belongs to the helicase family. (619 aa) | ||||
L486_01371 | DNA repair protein RAD16. (1127 aa) | ||||
L486_01281 | Uncharacterized protein. (689 aa) | ||||
L486_01464 | SAGA-associated factor 11. (352 aa) | ||||
L486_01478 | DNA cross-link repair 1A protein. (847 aa) | ||||
L486_01384 | SMC hinge domain-containing protein. (1597 aa) | ||||
L486_01529 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) | ||||
L486_01544 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1111 aa) | ||||
L486_01556 | WD_REPEATS_REGION domain-containing protein. (583 aa) | ||||
L486_01567 | DASH complex subunit DAM1. (189 aa) | ||||
L486_01708 | Uncharacterized protein. (424 aa) | ||||
L486_01848 | Histone acetyltransferase type B subunit 2. (433 aa) | ||||
L486_01894 | Protein FAM50. (341 aa) | ||||
L486_01964 | YL1_C domain-containing protein. (620 aa) | ||||
L486_01956 | Uncharacterized protein. (1816 aa) | ||||
L486_01861 | SWIB domain-containing protein. (481 aa) | ||||
L486_01997 | Uncharacterized protein. (980 aa) |