STRINGSTRING
L486_03328 L486_03328 L486_08344 L486_08344 L486_08316 L486_08316 L486_08396 L486_08396 L486_08203 L486_08203 L486_08213 L486_08213 L486_08169 L486_08169 L486_08217 L486_08217 L486_08378 L486_08378 L486_08325 L486_08325 L486_08357 L486_08357 L486_07974 L486_07974 L486_08397 L486_08397 L486_08109 L486_08109 L486_08001 L486_08001 L486_07960 L486_07960 L486_07760 L486_07760 PIF1 PIF1 L486_07780 L486_07780 L486_07801 L486_07801 L486_07822 L486_07822 L486_08092 L486_08092 L486_07787 L486_07787 L486_07902 L486_07902 L486_07706 L486_07706 L486_07803 L486_07803 L486_07887 L486_07887 L486_07886 L486_07886 L486_07585 L486_07585 L486_07898 L486_07898 L486_07595 L486_07595 L486_07752 L486_07752 L486_07488 L486_07488 L486_07664 L486_07664 L486_07900 L486_07900 L486_07209 L486_07209 L486_07926 L486_07926 L486_07570 L486_07570 L486_07576 L486_07576 L486_07382 L486_07382 L486_07212 L486_07212 L486_07395 L486_07395 L486_07310 L486_07310 L486_06922 L486_06922 L486_07447 L486_07447 L486_07327 L486_07327 L486_07373 L486_07373 L486_07043 L486_07043 L486_07439 L486_07439 L486_06429 L486_06429 L486_06961 L486_06961 L486_06457 L486_06457 L486_07051 L486_07051 L486_07077 L486_07077 L486_06984 L486_06984 L486_07078 L486_07078 L486_06585 L486_06585 L486_06610 L486_06610 L486_06755 L486_06755 L486_06580 L486_06580 L486_06472 L486_06472 L486_06451 L486_06451 L486_06623 L486_06623 L486_06704 L486_06704 L486_06690 L486_06690 L486_06688 L486_06688 L486_06670 L486_06670 MCM7 MCM7 L486_06697 L486_06697 L486_06163 L486_06163 L486_06041 L486_06041 L486_06223 L486_06223 L486_06208 L486_06208 L486_06214 L486_06214 L486_06393 L486_06393 L486_06211 L486_06211 L486_05334 L486_05334 L486_06361 L486_06361 L486_05342 L486_05342 L486_05375 L486_05375 L486_05392 L486_05392 L486_05357 L486_05357 L486_05583 L486_05583 L486_05603 L486_05603 L486_05495 L486_05495 L486_05677 L486_05677 L486_05718 L486_05718 L486_05805 L486_05805 L486_05763 L486_05763 L486_05604 L486_05604 L486_05615 L486_05615 L486_05883 L486_05883 L486_05685 L486_05685 L486_05889 L486_05889 L486_05907 L486_05907 L486_05709 L486_05709 L486_05945 L486_05945 L486_05951 L486_05951 L486_05971 L486_05971 L486_04602 L486_04602 L486_04654 L486_04654 L486_04675 L486_04675 L486_04632 L486_04632 L486_05877 L486_05877 L486_04674 L486_04674 L486_04625 L486_04625 L486_04789 L486_04789 L486_04799 L486_04799 L486_04836 L486_04836 L486_04846 L486_04846 L486_04757 L486_04757 L486_04860 L486_04860 L486_04750 L486_04750 L486_04934 L486_04934 L486_04944 L486_04944 L486_04915 L486_04915 L486_04994 L486_04994 L486_04997 L486_04997 L486_04996 L486_04996 EFM7 EFM7 L486_04898 L486_04898 L486_05062 L486_05062 L486_05107 L486_05107 L486_05183 L486_05183 L486_05214 L486_05214 L486_05208 L486_05208 L486_05094 L486_05094 L486_05238 L486_05238 L486_05222 L486_05222 L486_05153 L486_05153 L486_05252 L486_05252 L486_05291 L486_05291 L486_05292 L486_05292 L486_03912 L486_03912 L486_03934 L486_03934 L486_03946 L486_03946 L486_03918 L486_03918 L486_03933 L486_03933 L486_03991 L486_03991 L486_04015 L486_04015 L486_04062 L486_04062 L486_04038 L486_04038 L486_04084 L486_04084 L486_04089 L486_04089 L486_04011 L486_04011 L486_04057 L486_04057 L486_04078 L486_04078 L486_04103 L486_04103 L486_04316 L486_04316 L486_04347 L486_04347 L486_04354 L486_04354 L486_04351 L486_04351 L486_04459 L486_04459 L486_04559 L486_04559 L486_04585 L486_04585 L486_04457 L486_04457 L486_03108 L486_03108 L486_03105 L486_03105 L486_03263 L486_03263 L486_03269 L486_03269 L486_03277 L486_03277 L486_03315 L486_03315 L486_03354 L486_03354 L486_03373 L486_03373 L486_03367 L486_03367 L486_03368 L486_03368 L486_03274 L486_03274 L486_03435 L486_03435 L486_03468 L486_03468 L486_03509 L486_03509 L486_03549 L486_03549 FEN1 FEN1 L486_03577 L486_03577 L486_03560 L486_03560 L486_03602 L486_03602 L486_03618 L486_03618 SUS1 SUS1 L486_03631 L486_03631 L486_03704 L486_03704 L486_03802 L486_03802 L486_03696 L486_03696 L486_02077 L486_02077 L486_02049 L486_02049 L486_02152 L486_02152 L486_02184 L486_02184 L486_02222 L486_02222 L486_02241 L486_02241 L486_02310 L486_02310 L486_02325 L486_02325 L486_02343 L486_02343 L486_02221 L486_02221 L486_02234 L486_02234 L486_02384 L486_02384 L486_02405 L486_02405 L486_02419 L486_02419 L486_02366 L486_02366 L486_02495 L486_02495 L486_02519 L486_02519 L486_02526 L486_02526 L486_02544 L486_02544 L486_02551 L486_02551 L486_02594 L486_02594 L486_02628 L486_02628 L486_02664 L486_02664 L486_02680 L486_02680 L486_02577 L486_02577 L486_02671 L486_02671 L486_02721 L486_02721 L486_02783 L486_02783 L486_02826 L486_02826 L486_02833 L486_02833 L486_02867 L486_02867 L486_02915 L486_02915 L486_02824 L486_02824 L486_03031 L486_03031 L486_00074 L486_00074 L486_00106 L486_00106 L486_00139 L486_00139 L486_00148 L486_00148 L486_00182 L486_00182 L486_00244 L486_00244 L486_00157 L486_00157 L486_00323 L486_00323 L486_00337 L486_00337 L486_00219 L486_00219 L486_00318 L486_00318 KAE1 KAE1 L486_00239 L486_00239 L486_00396 L486_00396 L486_00409 L486_00409 L486_00407 L486_00407 L486_00394 L486_00394 L486_00589 L486_00589 L486_00528 L486_00528 L486_00661 L486_00661 L486_00675 L486_00675 L486_00687 L486_00687 L486_00618 L486_00618 L486_00753 L486_00753 L486_00668 L486_00668 L486_00766 L486_00766 L486_00821 L486_00821 L486_00887 L486_00887 L486_00916 L486_00916 L486_00969 L486_00969 L486_00850 L486_00850 L486_00978 L486_00978 L486_00911 L486_00911 L486_01055 L486_01055 L486_01069 L486_01069 L486_01138 L486_01138 L486_01157 L486_01157 L486_01176 L486_01176 L486_01222 L486_01222 L486_01246 L486_01246 L486_01231 L486_01231 L486_01298 L486_01298 L486_01371 L486_01371 L486_01281 L486_01281 L486_01464 L486_01464 L486_01478 L486_01478 L486_01384 L486_01384 L486_01529 L486_01529 L486_01544 L486_01544 L486_01556 L486_01556 L486_01567 L486_01567 L486_01708 L486_01708 L486_01848 L486_01848 L486_01894 L486_01894 L486_01964 L486_01964 L486_01956 L486_01956 L486_01861 L486_01861 L486_01997 L486_01997
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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L486_03328DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (973 aa)
L486_08344Chromo domain-containing protein. (908 aa)
L486_08316Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (554 aa)
L486_08396Uncharacterized protein. (1166 aa)
L486_08203HABP4_PAI-RBP1 domain-containing protein. (375 aa)
L486_08213CBFD_NFYB_HMF domain-containing protein. (212 aa)
L486_08169Nuclear DNA helicase II. (1611 aa)
L486_08217Uncharacterized protein. (881 aa)
L486_08378Uncharacterized protein. (357 aa)
L486_08325Zf-rbx1 domain-containing protein. (91 aa)
L486_08357Chromo domain-containing protein. (658 aa)
L486_07974TTK protein kinase. (895 aa)
L486_08397GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (358 aa)
L486_08109Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (749 aa)
L486_08001Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (507 aa)
L486_07960Uncharacterized protein. (173 aa)
L486_07760Uncharacterized protein. (894 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (717 aa)
L486_07780ATP-dependent helicase. (1054 aa)
L486_07801Chromatin assembly factor 1 subunit B. (833 aa)
L486_07822RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. (451 aa)
L486_08092Anaphase-promoting complex subunit 10. (237 aa)
L486_07787Compass component swd1. (482 aa)
L486_07902DUF3421 domain-containing protein. (398 aa)
L486_07706Meiotic recombinase Dmc1; Belongs to the RecA family. (350 aa)
L486_07803DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (344 aa)
L486_07887Condensin complex subunit 3. (1013 aa)
L486_07886Kinetochore protein Nuf2. (452 aa)
L486_07585Cytoplasmic protein. (378 aa)
L486_07898TFIIH basal transcription factor complex TTD-A subunit. (81 aa)
L486_07595DNA repair and recombination protein RAD54-like protein. (817 aa)
L486_07752SWR1-complex protein 4. (462 aa)
L486_07488Uncharacterized protein. (1430 aa)
L486_07664Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (613 aa)
L486_07900Uncharacterized protein. (793 aa)
L486_07209Histone H2B; Belongs to the histone H2B family. (139 aa)
L486_07926DNA excision repair protein ERCC-3. (876 aa)
L486_07570Structural maintenance of chromosomes protein. (1306 aa)
L486_07576CBFD_NFYB_HMF domain-containing protein. (138 aa)
L486_07382ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (956 aa)
L486_07212RFX-type winged-helix domain-containing protein. (753 aa)
L486_07395Uncharacterized protein. (483 aa)
L486_07310Uncharacterized protein. (1365 aa)
L486_06922FACT complex subunit SPT16. (1045 aa)
L486_07447Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (784 aa)
L486_07327Uncharacterized protein. (1210 aa)
L486_07373Ku domain-containing protein. (865 aa)
L486_07043HRDC domain-containing protein. (969 aa)
L486_07439Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (317 aa)
L486_06429Bromo domain-containing protein. (833 aa)
L486_06961Uncharacterized protein. (470 aa)
L486_06457SUN domain-containing protein. (911 aa)
L486_07051DNA repair and recombination protein RAD54B. (1082 aa)
L486_07077Uncharacterized protein. (1173 aa)
L486_06984SET domain-containing protein. (1404 aa)
L486_07078Uncharacterized protein. (76 aa)
L486_06585Transcription elongation factor SPT6. (1560 aa)
L486_06610DNA helicase; Belongs to the MCM family. (965 aa)
L486_06755SHNi-TPR domain-containing protein. (475 aa)
L486_06580Sua5/YciO/YrdC/YwlC family protein. (492 aa)
L486_06472Structural maintenance of chromosomes protein. (1246 aa)
L486_06451HTH APSES-type domain-containing protein. (398 aa)
L486_06623GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (274 aa)
L486_06704RP/EB family microtubule-associated protein. (253 aa)
L486_06690Uncharacterized protein. (369 aa)
L486_06688Chromosome transmission fidelity protein 1. (891 aa)
L486_06670Brg1-associated factor b; Belongs to the actin family. (474 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (797 aa)
L486_06697DNA helicase; Belongs to the MCM family. (755 aa)
L486_06163mRNA export factor. (360 aa)
L486_06041Mortality factor 4-like protein 1. (313 aa)
L486_06223Uncharacterized protein. (225 aa)
L486_06208Spc7 domain-containing protein. (1096 aa)
L486_06214DNA helicase; Belongs to the MCM family. (998 aa)
L486_06393Uncharacterized protein. (346 aa)
L486_06211Uncharacterized protein. (1474 aa)
L486_05334Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (921 aa)
L486_06361Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (3049 aa)
L486_05342Uncharacterized protein. (717 aa)
L486_05375Uncharacterized protein. (577 aa)
L486_05392Uncharacterized protein. (307 aa)
L486_05357Uncharacterized protein; Belongs to the CGI121/TPRKB family. (226 aa)
L486_05583Uncharacterized protein. (185 aa)
L486_05603PHD-type domain-containing protein. (1125 aa)
L486_05495Uncharacterized protein. (734 aa)
L486_05677DNA repair protein RAD50. (1360 aa)
L486_05718Uncharacterized protein. (721 aa)
L486_05805Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (620 aa)
L486_05763WD_REPEATS_REGION domain-containing protein. (429 aa)
L486_05604Compass component swd2. (428 aa)
L486_05615Uncharacterized protein. (559 aa)
L486_05883Uncharacterized protein. (645 aa)
L486_05685INCENP_ARK-bind domain-containing protein. (1234 aa)
L486_05889Uncharacterized protein. (1073 aa)
L486_05907Sister chromatid cohesion protein DCC1. (414 aa)
L486_05709Uncharacterized protein. (111 aa)
L486_05945Helicase C-terminal domain-containing protein. (912 aa)
L486_05951Chromatin modification-related protein. (350 aa)
L486_05971Helicase ATP-binding domain-containing protein. (891 aa)
L486_04602RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. (489 aa)
L486_04654B30.2/SPRY domain-containing protein. (657 aa)
L486_04675RNA polymerase II-associated factor 1. (453 aa)
L486_04632Uncharacterized protein. (1321 aa)
L486_05877JmjC domain-containing protein. (425 aa)
L486_04674Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2240 aa)
L486_04625DNA helicase; Belongs to the MCM family. (874 aa)
L486_04789Uncharacterized protein. (693 aa)
L486_04799Uncharacterized protein. (733 aa)
L486_04836Deacetylase sirtuin-type domain-containing protein. (474 aa)
L486_04846TATA-binding protein-associated factor. (1880 aa)
L486_04757DNA replication ATP-dependent helicase Dna2. (1348 aa)
L486_04860Nucleosome assembly protein 1-like 1; Belongs to the nucleosome assembly protein (NAP) family. (424 aa)
L486_04750DNA polymerase eta subunit. (743 aa)
L486_04934Uncharacterized protein. (438 aa)
L486_04944Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (265 aa)
L486_04915Transcriptional activator SPT8. (742 aa)
L486_04994Chromatin modification-related protein. (540 aa)
L486_04997RNA-dependent RNA polymerase. (882 aa)
L486_04996Uncharacterized protein. (222 aa)
EFM7Protein N-terminal and lysine N-methyltransferase EFM7; S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono-and dimethylation of 'Lys-3'. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family. (296 aa)
L486_04898Anaphase-promoting complex subunit 6. (880 aa)
L486_05062PHD-type domain-containing protein. (917 aa)
L486_05107Uncharacterized protein. (680 aa)
L486_05183JmjC domain-containing protein. (789 aa)
L486_05214DNA repair protein. (329 aa)
L486_05208Chromo domain-containing protein. (243 aa)
L486_05094Uncharacterized protein. (263 aa)
L486_05238DNA helicase; Belongs to the MCM family. (929 aa)
L486_05222Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1207 aa)
L486_05153DNA replication complex GINS protein PSF1. (228 aa)
L486_05252Uncharacterized protein. (477 aa)
L486_05291Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1130 aa)
L486_05292Zinc finger HIT domain-containing protein 1. (169 aa)
L486_03912DNA helicase II/ATP-dependent DNA helicase PcrA. (1078 aa)
L486_03934H15 domain-containing protein. (134 aa)
L486_03946Uncharacterized protein. (884 aa)
L486_03918Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (446 aa)
L486_03933Histone deacetylase 6/10. (861 aa)
L486_03991Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (740 aa)
L486_04015Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (289 aa)
L486_04062Uncharacterized protein. (307 aa)
L486_04038Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. (608 aa)
L486_04084Acetyltransf_13 domain-containing protein. (454 aa)
L486_04089Uncharacterized protein. (1144 aa)
L486_04011Uncharacterized protein. (1339 aa)
L486_04057DNA excision repair protein ERCC-2. (806 aa)
L486_04078Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (423 aa)
L486_04103Cleft lip and palate associated transmembrane protein. (616 aa)
L486_04316Uncharacterized protein. (1646 aa)
L486_04347Transcription activator snf2l1. (1095 aa)
L486_04354BCNT-C domain-containing protein. (286 aa)
L486_04351Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (478 aa)
L486_04459Cohesin complex subunit SA-1/2. (1359 aa)
L486_04559Uncharacterized protein. (1769 aa)
L486_04585DNA mismatch repair protein MSH2; Component of the post-replicative DNA mismatch repair system (MMR). (973 aa)
L486_04457Ubiquitin-conjugating enzyme E2 2; Belongs to the ubiquitin-conjugating enzyme family. (182 aa)
L486_03108Uncharacterized protein. (1660 aa)
L486_03105NAD-dependent histone deacetylase SIR2. (565 aa)
L486_03263Uncharacterized protein. (614 aa)
L486_0326926S protease regulatory subunit 8; Belongs to the AAA ATPase family. (407 aa)
L486_03277Uncharacterized protein. (1262 aa)
L486_03315COP9 signalosome complex subunit 12. (403 aa)
L486_03354Uncharacterized protein. (496 aa)
L486_03373PAPA-1 domain-containing protein. (413 aa)
L486_03367Poly(RC)-binding protein 2/3/4. (394 aa)
L486_03368Uncharacterized protein. (1067 aa)
L486_03274Actin-like protein ARP6; Belongs to the actin family. (464 aa)
L486_03435Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (140 aa)
L486_03468Beta-lactamase domain-containing protein. (299 aa)
L486_03509Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (898 aa)
L486_03549Nuclear pore complex protein Nup155. (1331 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (439 aa)
L486_03577Uncharacterized protein. (1981 aa)
L486_03560E3 ubiquitin-protein ligase SHPRH. (1660 aa)
L486_03602Uncharacterized protein. (635 aa)
L486_03618Uncharacterized protein. (526 aa)
SUS1Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex required for deubiquitination of [...] (100 aa)
L486_03631ATPase. (572 aa)
L486_03704Uncharacterized protein. (1702 aa)
L486_03802CUE domain-containing protein. (934 aa)
L486_03696Uncharacterized protein. (492 aa)
L486_02077CENP-C_C domain-containing protein. (724 aa)
L486_02049Anaphase-promoting complex subunit 8. (596 aa)
L486_02152Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (648 aa)
L486_02184Chromatin modification-related protein. (485 aa)
L486_02222DNA repair protein Rad8. (2472 aa)
L486_02241Uncharacterized protein. (665 aa)
L486_02310HORMA domain-containing protein. (926 aa)
L486_02325Uncharacterized protein. (641 aa)
L486_0234326S proteasome regulatory subunit N7. (382 aa)
L486_02221Uncharacterized protein. (804 aa)
L486_02234Transcription initiation factor TFIID subunit 9B. (214 aa)
L486_02384TBPIP domain-containing protein. (283 aa)
L486_02405ATP-dependent helicase STH1/SNF2. (1540 aa)
L486_02419Uncharacterized protein. (653 aa)
L486_02366Uncharacterized protein; Belongs to the actin family. (745 aa)
L486_02495Histone H2A; Belongs to the histone H2A family. (139 aa)
L486_02519Helicase. (859 aa)
L486_02526Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1412 aa)
L486_02544Uncharacterized protein. (1003 aa)
L486_02551Checkpoint protein; Belongs to the HUS1 family. (307 aa)
L486_02594Bromodomain-containing factor 1. (906 aa)
L486_02628General transcriptional repressor. (1155 aa)
L486_02664Histone deacetylase 1/2. (626 aa)
L486_02680Uncharacterized protein. (1558 aa)
L486_02577PLK/PLK1 protein kinase. (773 aa)
L486_02671C2H2-type domain-containing protein. (845 aa)
L486_02721SET domain-containing protein. (452 aa)
L486_02783Uncharacterized protein. (684 aa)
L486_02826TYR_PHOSPHATASE_2 domain-containing protein. (747 aa)
L486_02833Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
L486_02867Sister chromatid cohesion protein. (1959 aa)
L486_02915FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (584 aa)
L486_02824Uncharacterized protein. (183 aa)
L486_03031Uncharacterized protein. (307 aa)
L486_00074Histone chaperone ASF1. (293 aa)
L486_00106AAA domain-containing protein. (1051 aa)
L486_00139DNA repair protein RAD5. (1197 aa)
L486_00148INO80 complex subunit C. (264 aa)
L486_00182Uncharacterized protein. (476 aa)
L486_00244Kinesin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1045 aa)
L486_00157Uncharacterized protein. (1130 aa)
L486_00323Histone acetyltransferase. (913 aa)
L486_00337Deacetylase sirtuin-type domain-containing protein. (591 aa)
L486_00219ARID domain-containing protein. (1199 aa)
L486_00318Uncharacterized protein. (765 aa)
KAE1tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (380 aa)
L486_00239Uncharacterized protein. (481 aa)
L486_00396Rad51 domain-containing protein. (411 aa)
L486_00409tRNA dimethylallyltransferase. (553 aa)
L486_00407JmjC domain-containing protein. (280 aa)
L486_00394DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1492 aa)
L486_00589DNA helicase. (754 aa)
L486_00528Uncharacterized protein. (1933 aa)
L486_00661Uncharacterized protein. (234 aa)
L486_00675Hist_deacetyl domain-containing protein. (464 aa)
L486_00687FK506-binding protein. (430 aa)
L486_00618Uncharacterized protein. (933 aa)
L486_00753Uncharacterized protein. (985 aa)
L486_00668zf-GRF domain-containing protein. (265 aa)
L486_00766Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (872 aa)
L486_00821Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. (115 aa)
L486_00887Uncharacterized protein. (389 aa)
L486_00916Ku domain-containing protein. (753 aa)
L486_00969Telomere_reg-2 domain-containing protein. (1068 aa)
L486_00850DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (905 aa)
L486_00978E3 ubiquitin protein ligase. (840 aa)
L486_00911Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (801 aa)
L486_01055Chromodomain-helicase-DNA-binding protein 1. (1562 aa)
L486_01069Uncharacterized protein. (676 aa)
L486_01138Structural maintenance of chromosomes protein. (1220 aa)
L486_01157CULLIN_2 domain-containing protein; Belongs to the cullin family. (814 aa)
L486_01176NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (413 aa)
L486_01222Uncharacterized protein. (762 aa)
L486_01246DNA polymerase epsilon p12 subunit. (335 aa)
L486_01231SCA7 domain-containing protein. (461 aa)
L486_01298ATP-dependent DNA helicase; Belongs to the helicase family. (619 aa)
L486_01371DNA repair protein RAD16. (1127 aa)
L486_01281Uncharacterized protein. (689 aa)
L486_01464SAGA-associated factor 11. (352 aa)
L486_01478DNA cross-link repair 1A protein. (847 aa)
L486_01384SMC hinge domain-containing protein. (1597 aa)
L486_01529Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
L486_01544Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1111 aa)
L486_01556WD_REPEATS_REGION domain-containing protein. (583 aa)
L486_01567DASH complex subunit DAM1. (189 aa)
L486_01708Uncharacterized protein. (424 aa)
L486_01848Histone acetyltransferase type B subunit 2. (433 aa)
L486_01894Protein FAM50. (341 aa)
L486_01964YL1_C domain-containing protein. (620 aa)
L486_01956Uncharacterized protein. (1816 aa)
L486_01861SWIB domain-containing protein. (481 aa)
L486_01997Uncharacterized protein. (980 aa)
Your Current Organism:
Kwoniella mangroviensis
NCBI taxonomy Id: 1331196
Other names: K. mangroviensis CBS 10435, Kwoniella mangroviensis CBS 10435, Kwoniella mangroviensis CBS10435
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