STRINGSTRING
L486_08249 L486_08249 L486_07778 L486_07778 L486_08071 L486_08071 L486_07794 L486_07794 L486_07604 L486_07604 L486_07507 L486_07507 L486_07165 L486_07165 L486_07008 L486_07008 L486_07025 L486_07025 L486_06438 L486_06438 L486_06565 L486_06565 L486_06553 L486_06553 L486_06126 L486_06126 L486_05633 L486_05633 L486_05647 L486_05647 L486_05585 L486_05585 L486_05910 L486_05910 L486_04871 L486_04871 L486_05205 L486_05205 L486_03879 L486_03879 L486_05219 L486_05219 L486_05255 L486_05255 L486_03929 L486_03929 L486_04447 L486_04447 L486_03262 L486_03262 L486_03281 L486_03281 L486_03507 L486_03507 FEN1 FEN1 L486_03451 L486_03451 L486_03813 L486_03813 L486_02538 L486_02538 L486_02548 L486_02548 L486_02537 L486_02537 L486_02641 L486_02641 L486_02763 L486_02763 L486_02820 L486_02820 L486_02922 L486_02922 L486_02932 L486_02932 L486_00171 L486_00171 L486_00273 L486_00273 L486_00395 L486_00395 L486_00462 L486_00462 L486_00543 L486_00543 L486_00902 L486_00902 L486_00936 L486_00936 L486_01003 L486_01003 L486_01305 L486_01305 L486_01345 L486_01345 L486_01372 L486_01372 L486_01405 L486_01405 L486_01544 L486_01544 L486_01793 L486_01793 L486_01878 L486_01878
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
L486_08249Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa)
L486_07778tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (303 aa)
L486_08071Ketol-acid reductoisomerase, mitochondrial; Belongs to the ketol-acid reductoisomerase family. (405 aa)
L486_07794Inositol-1-monophosphatase. (302 aa)
L486_07604Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1572 aa)
L486_07507Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1789 aa)
L486_07165Citrate lyase subunit beta-like protein. (342 aa)
L486_07008Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (487 aa)
L486_07025Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (430 aa)
L486_06438Isocitrate lyase. (491 aa)
L486_06565Magnesium transporter. (497 aa)
L486_06553Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (422 aa)
L486_06126Pyruvate kinase; Belongs to the pyruvate kinase family. (584 aa)
L486_05633Plasma membrane ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. (998 aa)
L486_05647Phosphoglucomutase; Belongs to the phosphohexose mutase family. (572 aa)
L486_05585PP2Cc protein phosphatase. (538 aa)
L486_05910Probable acetate kinase. (434 aa)
L486_04871Fatty acid synthase subunit alpha. (1435 aa)
L486_05205Protein phosphatase; Belongs to the PP2C family. (371 aa)
L486_03879Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (365 aa)
L486_05219DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. (1687 aa)
L486_05255Plasma membrane ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. (1108 aa)
L486_03929Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (367 aa)
L486_04447Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (421 aa)
L486_03262ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (967 aa)
L486_03281Pyruvate decarboxylase. (618 aa)
L486_03507Glutathione synthetase. (522 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (439 aa)
L486_03451Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (688 aa)
L486_03813Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1551 aa)
L486_02538Protein phosphatase; Belongs to the PP2C family. (670 aa)
L486_02548Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1121 aa)
L486_02537Isocitrate lyase. (551 aa)
L486_02641PPM-type phosphatase domain-containing protein. (511 aa)
L486_02763S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (396 aa)
L486_02820Protein phosphatase. (498 aa)
L486_02922Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (679 aa)
L486_029325-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (230 aa)
L486_00171Acetolactate synthase. (722 aa)
L486_00273Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (193 aa)
L486_00395Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1333 aa)
L486_00462Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (430 aa)
L486_00543Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1265 aa)
L486_00902DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. (668 aa)
L486_00936Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (874 aa)
L486_01003Pyridoxal phosphate phosphatase phospho2. (244 aa)
L486_01305Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (395 aa)
L486_01345Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
L486_013723,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (241 aa)
L486_01405Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins. Belongs to the phosphohexose mutase family. (562 aa)
L486_01544Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1111 aa)
L486_01793Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (335 aa)
L486_01878Inositol-1-monophosphatase. (315 aa)
Your Current Organism:
Kwoniella mangroviensis
NCBI taxonomy Id: 1331196
Other names: K. mangroviensis CBS 10435, Kwoniella mangroviensis CBS 10435, Kwoniella mangroviensis CBS10435
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