46 items (Kwoniella mangroviensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	L486_07664	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (613 aa)
	L486_01815	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (432 aa)
	L486_01642	PA28_beta domain-containing protein. (275 aa)
	L486_01462	Cell division control protein 45. (727 aa)
	L486_01246	DNA polymerase epsilon p12 subunit. (335 aa)
	L486_01222	Uncharacterized protein. (762 aa)
	L486_00739	Uncharacterized protein. (611 aa)
	L486_00342	ORC_WH_C domain-containing protein. (443 aa)
	L486_00296	Uncharacterized protein. (542 aa)
	L486_00123	Uncharacterized protein. (584 aa)
	L486_02978	DNA polymerase epsilon subunit B. (626 aa)
	L486_02623	Polyubiquitin. (381 aa)
	L486_02193	Uncharacterized protein. (545 aa)
	L486_02199	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2244 aa)
	L486_02107	Importin subunit alpha; Belongs to the importin alpha family. (525 aa)
	L486_02082	CMGC/CDK/CDK5 protein kinase; Belongs to the protein kinase superfamily. (285 aa)
	L486_02083	Uncharacterized protein. (162 aa)
	L486_02045	CIA30 domain-containing protein. (271 aa)
	L486_03790	Zf-primase domain-containing protein. (738 aa)
	L486_03795	DNA polymerase. (1496 aa)
	L486_03205	AAA domain-containing protein. (884 aa)
	L486_03176	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (510 aa)
	L486_04120	CMGC/CDK/CDC2 protein kinase; Belongs to the protein kinase superfamily. (296 aa)
	L486_04125	TPR_REGION domain-containing protein. (512 aa)
	L486_04081	ANAPC5 domain-containing protein. (729 aa)
	L486_05312	UDP-galactopyranose mutase. (527 aa)
	L486_05238	DNA helicase; Belongs to the MCM family. (929 aa)
	L486_05110	DNAJ domain-containing protein. (332 aa)
	L486_04625	DNA helicase; Belongs to the MCM family. (874 aa)
	L486_05959	Replication factor A2. (279 aa)
	L486_04728	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (829 aa)
	L486_05954	Ubiquitin-conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (211 aa)
	L486_05882	Regulatory subunit for Cdc7 protein kinase. (694 aa)
	L486_06364	Zds_C domain-containing protein. (1106 aa)
	L486_06214	DNA helicase; Belongs to the MCM family. (998 aa)
	L486_06697	DNA helicase; Belongs to the MCM family. (755 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (797 aa)
	L486_06799	Chromo domain-containing protein. (765 aa)
	L486_06610	DNA helicase; Belongs to the MCM family. (965 aa)
	L486_06818	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (725 aa)
	L486_07209	Histone H2B; Belongs to the histone H2B family. (139 aa)
	L486_07591	Polyubiquitin. (160 aa)
	L486_07882	CDC7 protein kinase. (915 aa)
	L486_08213	CBFD_NFYB_HMF domain-containing protein. (212 aa)
	L486_08299	Uncharacterized protein. (137 aa)
	L486_08312	Replication factor A3. (108 aa)

Your Current Organism:

Kwoniella mangroviensis

NCBI taxonomy Id: 1331196
Other names: K. mangroviensis CBS 10435, Kwoniella mangroviensis CBS 10435, Kwoniella mangroviensis CBS10435

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
L486_00123	L486_02045	A0A1B9IY90	A0A1B9IV12	Uncharacterized protein.	CIA30 domain-containing protein.	0.573
L486_00123	L486_02082	A0A1B9IY90	A0A1B9IV70	Uncharacterized protein.	CMGC/CDK/CDK5 protein kinase; Belongs to the protein kinase superfamily.	0.471
L486_00123	L486_02083	A0A1B9IY90	A0A1B9IV67	Uncharacterized protein.	Uncharacterized protein.	0.471
L486_00123	L486_02199	A0A1B9IY90	A0A1B9IVH1	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.469
L486_00123	L486_02623	A0A1B9IY90	A0A1B9IWN4	Uncharacterized protein.	Polyubiquitin.	0.579
L486_00123	L486_04120	A0A1B9IY90	A0A1B9IRC7	Uncharacterized protein.	CMGC/CDK/CDC2 protein kinase; Belongs to the protein kinase superfamily.	0.471
L486_00123	L486_05959	A0A1B9IY90	A0A1B9INZ1	Uncharacterized protein.	Replication factor A2.	0.797
L486_00123	L486_07209	A0A1B9IY90	A0A1B9IHD3	Uncharacterized protein.	Histone H2B; Belongs to the histone H2B family.	0.549
L486_00123	L486_07591	A0A1B9IY90	A0A1B9IHC7	Uncharacterized protein.	Polyubiquitin.	0.573
L486_00123	L486_07664	A0A1B9IY90	A0A1B9IH48	Uncharacterized protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.785
L486_00296	L486_00342	A0A1B9IYQ4	A0A1B9IZ67	Uncharacterized protein.	ORC_WH_C domain-containing protein.	0.999
L486_00296	L486_00739	A0A1B9IYQ4	A0A1B9IZX9	Uncharacterized protein.	Uncharacterized protein.	0.728
L486_00296	L486_01222	A0A1B9IYQ4	A0A1B9J1A0	Uncharacterized protein.	Uncharacterized protein.	0.999
L486_00296	L486_01462	A0A1B9IYQ4	A0A1B9J1Y7	Uncharacterized protein.	Cell division control protein 45.	0.943
L486_00296	L486_01815	A0A1B9IYQ4	A0A1B9J2Y8	Uncharacterized protein.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.889
L486_00296	L486_02082	A0A1B9IYQ4	A0A1B9IV70	Uncharacterized protein.	CMGC/CDK/CDK5 protein kinase; Belongs to the protein kinase superfamily.	0.716
L486_00296	L486_02083	A0A1B9IYQ4	A0A1B9IV67	Uncharacterized protein.	Uncharacterized protein.	0.716
L486_00296	L486_02107	A0A1B9IYQ4	A0A1B9IV76	Uncharacterized protein.	Importin subunit alpha; Belongs to the importin alpha family.	0.664
L486_00296	L486_02193	A0A1B9IYQ4	A0A1B9IVH5	Uncharacterized protein.	Uncharacterized protein.	0.999
L486_00296	L486_02199	A0A1B9IYQ4	A0A1B9IVH1	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.758