(57 nodes) Pyrimidine metabolism network (Kwoniella mangroviensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	L486_01787	Nucleoside diphosphate kinase. (152 aa)
	L486_07213	Uncharacterized protein. (134 aa)
	L486_07358	Malonic semialdehyde reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (272 aa)
	L486_07326	dCMP deaminase. (363 aa)
	L486_06982	Cytidine deaminase. (115 aa)
	L486_06817	dUTP pyrophosphatase. (173 aa)
	L486_07419	Nudix hydrolase domain-containing protein. (205 aa)
	L486_07103	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (624 aa)
	L486_06981	Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. (396 aa)
	L486_07018	Thymidylate kinase. (226 aa)
	L486_06483	Chaperonin GroES; Belongs to the GroES chaperonin family. (125 aa)
	L486_06651	Guanosine-diphosphatase; Belongs to the GDA1/CD39 NTPase family. (712 aa)
	L486_06712	Uncharacterized protein. (244 aa)
	L486_06749	Endoribonuclease L-PSP. (130 aa)
	L486_06046	Endoribonuclease. (129 aa)
	L486_06291	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (882 aa)
	L486_06317	Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (298 aa)
	L486_05736	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (632 aa)
	L486_05930	Vacuolar protein. (610 aa)
	L486_04703	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (857 aa)
	L486_04739	MFS domain-containing protein. (559 aa)
	L486_04805	Hydrolase. (411 aa)
	L486_04639	Dihydropyrimidinase. (500 aa)
	L486_04849	Carbamoyl-phosphate synthase, large subunit. (2347 aa)
	L486_04786	Uncharacterized protein. (517 aa)
	L486_04930	Uncharacterized protein. (121 aa)
	L486_05202	Uridine kinase; Belongs to the uridine kinase family. (567 aa)
	L486_04178	Uncharacterized protein. (710 aa)
	L486_04219	Uncharacterized protein. (193 aa)
	L486_04223	Uncharacterized protein. (620 aa)
	L486_04485	Dihydroorotase, homodimeric type. (357 aa)
	L486_03175	Uncharacterized protein. (636 aa)
	L486_03208	Thymidylate synthase. (322 aa)
	L486_03294	TLC domain-containing protein. (307 aa)
	L486_03365	Nucleoside-diphosphate kinase; Belongs to the NDK family. (210 aa)
	L486_03539	Carbamoyl-phosphate synthase, small subunit. (450 aa)
	L486_03612	Zn(2)-C6 fungal-type domain-containing protein. (852 aa)
	L486_03740	HD domain-containing protein. (268 aa)
	L486_03819	Membrane transporter. (679 aa)
	L486_02135	MFS domain-containing protein. (568 aa)
	L486_02603	Ribonucleoside-diphosphate reductase subunit M2. (399 aa)
	L486_02880	Uncharacterized protein. (122 aa)
	L486_03011	Uncharacterized protein; Belongs to the 5'-nucleotidase family. (771 aa)
	L486_00061	5'/3'-nucleotidase SurE. (391 aa)
	L486_03047	Uncharacterized protein. (958 aa)
	L486_01221	Orotate phosphoribosyltransferase. (222 aa)
	L486_01307	Ribonucleoside-diphosphate reductase subunit M2. (442 aa)
	L486_08487	Fungal_trans domain-containing protein. (501 aa)
	L486_08540	Uncharacterized protein. (120 aa)
	L486_08202	Carbamoyl-phosphate synthase arginine-specific large chain. (1159 aa)
	L486_01758	Cytoplasmic protein. (546 aa)
	L486_01728	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (276 aa)
	L486_01706	Importin N-terminal domain-containing protein. (1062 aa)
	L486_01684	MFS domain-containing protein. (527 aa)
	L486_01553	Uracil phosphoribosyltransferase. (233 aa)
	L486_01555	Uracil phosphoribosyltransferase. (217 aa)
	L486_07536	Uncharacterized protein. (133 aa)

Your Current Organism:

Kwoniella mangroviensis

NCBI taxonomy Id: 1331196
Other names: K. mangroviensis CBS 10435, Kwoniella mangroviensis CBS 10435, Kwoniella mangroviensis CBS10435

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
L486_00061	L486_01758	A0A1B9IY20	A0A1B9J2S5	5'/3'-nucleotidase SurE.	Cytoplasmic protein.	0.896
L486_00061	L486_03011	A0A1B9IY20	A0A1B9IXS9	5'/3'-nucleotidase SurE.	Uncharacterized protein; Belongs to the 5'-nucleotidase family.	0.490
L486_00061	L486_06651	A0A1B9IY20	A0A1B9IK14	5'/3'-nucleotidase SurE.	Guanosine-diphosphatase; Belongs to the GDA1/CD39 NTPase family.	0.658
L486_00061	L486_06982	A0A1B9IY20	A0A1B9IIK3	5'/3'-nucleotidase SurE.	Cytidine deaminase.	0.666
L486_01221	L486_01553	A0A1B9J1C0	A0A1B9J284	Orotate phosphoribosyltransferase.	Uracil phosphoribosyltransferase.	0.428
L486_01221	L486_01706	A0A1B9J1C0	A0A1B9J2P2	Orotate phosphoribosyltransferase.	Importin N-terminal domain-containing protein.	0.496
L486_01221	L486_01728	A0A1B9J1C0	A0A1B9J2P8	Orotate phosphoribosyltransferase.	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family.	0.884
L486_01221	L486_03011	A0A1B9J1C0	A0A1B9IXS9	Orotate phosphoribosyltransferase.	Uncharacterized protein; Belongs to the 5'-nucleotidase family.	0.475
L486_01221	L486_03208	A0A1B9J1C0	A0A1B9IT45	Orotate phosphoribosyltransferase.	Thymidylate synthase.	0.459
L486_01221	L486_03539	A0A1B9J1C0	A0A1B9IU24	Orotate phosphoribosyltransferase.	Carbamoyl-phosphate synthase, small subunit.	0.713
L486_01221	L486_03612	A0A1B9J1C0	A0A1B9IU91	Orotate phosphoribosyltransferase.	Zn(2)-C6 fungal-type domain-containing protein.	0.773
L486_01221	L486_04485	A0A1B9J1C0	A0A1B9ISD8	Orotate phosphoribosyltransferase.	Dihydroorotase, homodimeric type.	0.725
L486_01221	L486_04639	A0A1B9J1C0	A0A1B9IP85	Orotate phosphoribosyltransferase.	Dihydropyrimidinase.	0.537
L486_01221	L486_04849	A0A1B9J1C0	A0A1B9IPG1	Orotate phosphoribosyltransferase.	Carbamoyl-phosphate synthase, large subunit.	0.757
L486_01221	L486_05202	A0A1B9J1C0	A0A1B9IQE5	Orotate phosphoribosyltransferase.	Uridine kinase; Belongs to the uridine kinase family.	0.475
L486_01221	L486_05930	A0A1B9J1C0	A0A1B9INP5	Orotate phosphoribosyltransferase.	Vacuolar protein.	0.475
L486_01221	L486_06317	A0A1B9J1C0	A0A1B9ILX4	Orotate phosphoribosyltransferase.	Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	0.768
L486_01221	L486_06651	A0A1B9J1C0	A0A1B9IK14	Orotate phosphoribosyltransferase.	Guanosine-diphosphatase; Belongs to the GDA1/CD39 NTPase family.	0.493
L486_01221	L486_07018	A0A1B9J1C0	A0A1B9IJI0	Orotate phosphoribosyltransferase.	Thymidylate kinase.	0.650
L486_01221	L486_07103	A0A1B9J1C0	A0A1B9IIW5	Orotate phosphoribosyltransferase.	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	0.969