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| | AGN02626.1 | COG1958 Small nuclear ribonucleoprotein (snRNP) homolog. (88 aa) |
| | tyrS | tyrosyl-tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily. (331 aa) |
| | rpoH | DNA-directed RNA polymerase subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (75 aa) |
| | AGN02645.1 | COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit; Belongs to the RNA polymerase beta chain family. (522 aa) |
| | AGN02646.1 | DNA-directed RNA polymerase subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (609 aa) |
| | AGN02647.1 | DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (974 aa) |
| | rpoA2 | DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (399 aa) |
| | nusA | Transcription elongation factor NusA-like protein; Participates in transcription termination. Belongs to the NusA family. (142 aa) |
| | alaS | alanyl-tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (926 aa) |
| | AGN01633.1 | KEOPS complex Cgi121-like subunit. (183 aa) |
| | polC | DNA polymerase II large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1206 aa) |
| | AGN01579.1 | COG0180 Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (344 aa) |
| | leuS-2 | COG0495 Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (912 aa) |
| | rplX | COG2157 Ribosomal protein L20A (L18A). (58 aa) |
| | AGN01505.1 | Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family protein; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Belongs to the eIF-2B alpha/beta/delta subunits family. (440 aa) |
| | AGN01494.1 | Methyltransferase type 11; COG0500 SAM-dependent methyltransferases. (210 aa) |
| | AGN01447.1 | COG0681 Signal peptidase I. (265 aa) |
| | ileS | isoleucyl-tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1092 aa) |
| | AGN01360.1 | Hypothetical protein; COG1553 Uncharacterized conserved protein involved in intracellular sulfur reduction. (107 aa) |
| | AGN01301.1 | COG1094 Predicted RNA-binding protein (contains KH domains). (186 aa) |
| | AGN01299.1 | L-seryl-tRNA(Ser) seleniumtransferase; COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase]. (402 aa) |
| | AGN01296.1 | COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS. (105 aa) |
| | rtcB | Hypothetical protein; Belongs to the RtcB family. (977 aa) |
| | AGN01179.1 | COG0456 Acetyltransferases. (184 aa) |
| | taw1 | tRNA-modifying enzyme; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (331 aa) |
| | AGN01169.1 | tRNA-guanine transglycosylase; COG0343 Queuine/archaeosine tRNA-ribosyltransferase. (572 aa) |
| | AGN01167.1 | tRNA-guanine transglycosylase; COG0343 Queuine/archaeosine tRNA-ribosyltransferase. (416 aa) |
| | AGN01153.1 | tRNA-modifying enzyme; COG0731 Fe-S oxidoreductases. (46 aa) |
| | argS | COG0018 Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (605 aa) |
| | prf1 | Peptide chain release factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (422 aa) |
| | AGN01130.1 | GCN5-like N-acetyltransferase; COG0454 Histone acetyltransferase HPA2 and related acetyltransferases. (187 aa) |
| | AGN01128.1 | COG0681 Signal peptidase I. (387 aa) |
| | trm1 | N(2),N(2)-dimethylguanosine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (368 aa) |
| | rps8e | COG2007 Ribosomal protein S8E. (123 aa) |
| | AGN01072.1 | Hypothetical protein; COG1645 Uncharacterized Zn-finger containing protein. (222 aa) |
| | AGN01066.1 | COG0423 Glycyl-tRNA synthetase (class II). (605 aa) |
| | rpl39e | COG2167 Ribosomal protein L39E; Belongs to the eukaryotic ribosomal protein eL39 family. (50 aa) |
| | rpl31e | COG2097 Ribosomal protein L31E; Belongs to the ribosomal protein L31e family. (92 aa) |
| | eif6 | Translation initiation factor IF-6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (221 aa) |
| | rrmJ | 23S rRNA methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (270 aa) |
| | rps13p | 30S ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (178 aa) |
| | rps4p | 30S ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (174 aa) |
| | rps11p | 30S ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (129 aa) |
| | rpoD | DNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. (260 aa) |
| | rpl18e | COG1727 Ribosomal protein L18E; Belongs to the eukaryotic ribosomal protein eL18 family. (116 aa) |
| | rpl13p | 50S ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (145 aa) |
| | rps9p | COG0103 Ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (131 aa) |
| | rpoN | DNA-directed RNA polymerase subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (66 aa) |
| | rpoK | DNA-directed RNA polymerase subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (58 aa) |
| | rps2P | COG0052 Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (258 aa) |
| | AGN00987.1 | Hypothetical protein; COG1266 Predicted metal-dependent membrane protease. (232 aa) |
| | AGN00960.1 | COG0456 Acetyltransferases. (157 aa) |
| | AGN00959.1 | Hypothetical protein; COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase). (473 aa) |
| | rpl44e | 50S ribosomal protein L44e; Binds to the 23S rRNA. (93 aa) |
| | rps27e | COG2051 Ribosomal protein S27E. (62 aa) |
| | AGN00950.1 | COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha). (265 aa) |
| | nop10 | H/ACA RNA-protein complex component Nop10p; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (58 aa) |
| | AGN00835.1 | Hypothetical protein; COG1266 Predicted metal-dependent membrane protease. (311 aa) |
| | AGN00833.1 | Hypothetical protein; COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit. (295 aa) |
| | AGN00832.1 | Hypothetical protein; COG0607 Rhodanese-related sulfurtransferase. (261 aa) |
| | AGN00816.1 | COG1601 Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain. (202 aa) |
| | AGN00813.1 | Beta-lactamase domain protein; COG0607 Rhodanese-related sulfurtransferase. (381 aa) |
| | rpl40e | COG1552 Ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. (49 aa) |
| | AGN00810.1 | Hypothetical protein; Probable pre-rRNA processing protein involved in ribosome biogenesis; Belongs to the TSR3 family. (173 aa) |
| | aspC | aspartyl-tRNA ligase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn). (434 aa) |
| | gatB | aspartyl/glutamyl-tRNA amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (501 aa) |
| | lysK | COG1384 Lysyl-tRNA synthetase (class I); Belongs to the class-I aminoacyl-tRNA synthetase family. (617 aa) |
| | rpl15e | COG1632 Ribosomal protein L15E; Belongs to the eukaryotic ribosomal protein eL15 family. (196 aa) |
| | AGN00700.1 | COG0478 RIO-like serine/threonine protein kinase fused to N-terminal HTH domain. (301 aa) |
| | AGN00641.1 | COG0607 Rhodanese-related sulfurtransferase. (147 aa) |
| | eif5a | Translation initiation factor IF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (127 aa) |
| | AGN00631.1 | COG1899 Deoxyhypusine synthase. (352 aa) |
| | leuS | COG0495 Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (925 aa) |
| | AGN00589.1 | COG2016 Predicted RNA-binding protein (contains PUA domain). (164 aa) |
| | nusG | Transcription antitermination protein NusG; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (150 aa) |
| | rps19e | 30S ribosomal protein S19e; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (151 aa) |
| | AGN00564.1 | SirA family protein. (57 aa) |
| | AGN00557.1 | COG0425 Predicted redox protein, regulator of disulfide bond formation. (81 aa) |
| | pth | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. (112 aa) |
| | truD | tRNA pseudouridine synthase D; Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (495 aa) |
| | rpl37ae | 50S ribosomal protein L37Ae; Binds to the 23S rRNA. (94 aa) |
| | rpoP | DNA-directed RNA polymerase subunit P; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (45 aa) |
| | AGN00536.1 | KEOPS complex Pcc1-like subunit. (81 aa) |
| | ef1B | Elongation factor 1-beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (88 aa) |
| | map | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. (299 aa) |
| | AGN00511.1 | COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP. (740 aa) |
| | tbp | Transcription factor; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (186 aa) |
| | AGN00503.1 | RNA methylase; COG1041 Predicted DNA modification methylase. (358 aa) |
| | AGN00492.1 | COG0095 Lipoate-protein ligase A. (227 aa) |
| | AGN00447.1 | Thioesterase; COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism. (128 aa) |
| | AGN00445.1 | N-acetyltransferase GCN5; COG1246 N-acetylglutamate synthase and related acetyltransferases. (159 aa) |
| | gatD | glutamyl-tRNA(Gln) amidotransferase subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (427 aa) |
| | top6B | DNA topoisomerase VI subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (821 aa) |
| | eif1a | Translation initiation factor aIF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (94 aa) |
| | AGN00295.1 | Hypothetical protein; COG2520 Predicted methyltransferase. (328 aa) |
| | cca | tRNA CCA-pyrophosphorylase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (461 aa) |
| | AGN00289.1 | COG2036 Histones H3 and H4. (145 aa) |
| | AGN00279.1 | COG0095 Lipoate-protein ligase A. (287 aa) |
| | tfx | Transcriptional regulator; COG1356 Uncharacterized protein conserved in archaea. (169 aa) |
| | AGN00241.1 | COG1243 Histone acetyltransferase. (567 aa) |
| | AGN00238.1 | Nucleic acid binding OB-fold tRNA/helicase-type; COG1107 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain. (737 aa) |
| | rpl21e | COG2139 Ribosomal protein L21E; Belongs to the eukaryotic ribosomal protein eL21 family. (96 aa) |
| | AGN00234.1 | DNA-directed RNA polymerase subunit F; COG1460 Uncharacterized protein conserved in archaea. (118 aa) |
| | ksgA | 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. (279 aa) |
| | AGN00224.1 | COG2075 Ribosomal protein L24E. (100 aa) |
| | rps28e | COG2053 Ribosomal protein S28E/S33; Belongs to the eukaryotic ribosomal protein eS28 family. (74 aa) |
| | rpl7ae | 50S ribosomal protein L7Ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (120 aa) |
| | kptA | RNA:NAD 2'-phosphotransferase; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase. (209 aa) |
| | tmcA | Putative P-loop ATPase fused to an acetyltransferase; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (824 aa) |
| | tfb | Transcription factor TFIIB cyclin-like protein; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (320 aa) |
| | AGN00185.1 | Hypothetical protein; COG1503 Peptide chain release factor 1 (eRF1). (300 aa) |
| | gltX | glutamyl-tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (571 aa) |
| | rtcA | RNA 3'-terminal-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. (350 aa) |
| | AGN00128.1 | MiaB-like tRNA modifying enzyme; COG0621 2-methylthioadenine synthetase. (418 aa) |
| | rps10 | Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (106 aa) |
| | AGM99992.1 | Dihydropyrimidine dehydrogenase; COG0042 tRNA-dihydrouridine synthase. (254 aa) |
| | AGM99986.1 | Beta-lactamase; COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III. (248 aa) |
| | AGN02662.1 | PBS lyase HEAT domain-containing protein repeat-containing protein; COG1413 FOG: HEAT repeat. (404 aa) |
| | rps3ae | COG1890 Ribosomal protein S3AE; Belongs to the eukaryotic ribosomal protein eS1 family. (211 aa) |
| | rps15p | COG0184 Ribosomal protein S15P/S13E. (154 aa) |
| | AGN02688.1 | Small GTP-binding protein; COG1163 Predicted GTPase. (368 aa) |
| | truB | H/ACA RNA-protein complex component Cbf5p; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (333 aa) |
| | eif2g | Translation initiation factor IF-2 subunit gamma; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (412 aa) |
| | AGN02718.1 | COG1095 DNA-directed RNA polymerase, subunit E'. (190 aa) |
| | spt4 | DNA-directed RNA polymerase subunit E; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. (65 aa) |
| | rps24e | COG2004 Ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family. (104 aa) |
| | rps27ae | COG1998 Ribosomal protein S27AE; Belongs to the eukaryotic ribosomal protein eS31 family. (44 aa) |
| | AGN02724.1 | Bifunctional UGMP family protein/serine/threonine protein kinase; COG0533 Metal-dependent proteases with possible chaperone activity. (565 aa) |
| | serS | seryl-tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (460 aa) |
| | valS | valyl-tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (975 aa) |
| | AGN02766.1 | ATPase RIL; COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog. (610 aa) |
| | trmY | Hypothetical protein; Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs; Belongs to the methyltransferase superfamily. TrmY family. (197 aa) |
| | pus10 | Pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. (459 aa) |
| | tfb-5 | Transcription factor TFIIB cyclin-related protein; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (322 aa) |
| | gatC | glutamyl-tRNA(Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (96 aa) |
| | gatA | aspartyl/glutamyl-tRNA amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (422 aa) |
| | AGN02900.1 | Elongator protein 3/MiaB/NifB; COG1244 Predicted Fe-S oxidoreductase. (369 aa) |
| | rpoL | DNA-directed RNA polymerase subunit L; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. (92 aa) |
| | tiaS | Hypothetical protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. (448 aa) |
| | cysS | COG0215 Cysteinyl-tRNA synthetase. (492 aa) |
| | pheS | COG0016 Phenylalanyl-tRNA synthetase alpha subunit. (560 aa) |
| | pheT | COG0072 Phenylalanyl-tRNA synthetase beta subunit. (620 aa) |
| | trpS | tryptophanyl-tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). (568 aa) |
| | AGN01693.1 | Hypothetical protein; Belongs to the LarC family. (491 aa) |
| | eif1a-2 | Translation initiation factor IF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (97 aa) |
| | tgtA | 7-cyano-7-deazaguanine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (502 aa) |
| | AGN01728.1 | tRNA-guanine transglycosylase, various specificities; COG1549 Queuine tRNA-ribosyltransferases, contain PUA domain. (605 aa) |
| | AGN01743.1 | RNA methylase, NOL1/NOP2/sun family protein; COG0144 tRNA and rRNA cytosine-C5-methylases; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (303 aa) |
| | tfb-2 | Transcription initiation factor TFB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (375 aa) |
| | tfb-3 | Transcription initiation factor TFIIIB, Brf1 subunit/transcription initiation factor TFIIB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (318 aa) |
| | AGN01807.1 | Bifunctional CAAX prenyl proteinase / zinc metalloproteinase; COG0501 Zn-dependent protease with chaperone function. (432 aa) |
| | proS | prolyl-tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (486 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (328 aa) |
| | thiI | Thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (402 aa) |
| | AGN01844.1 | tRNA 2'-O-methylase; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. (202 aa) |
| | tfe | Transcription factor TFIIE subunit alpha; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation [...] (175 aa) |
| | fusA | Elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (730 aa) |
| | AGN01868.1 | COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases. (493 aa) |
| | metG | methionyl-tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (732 aa) |
| | rnz | Ribonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (312 aa) |
| | rps10p | 30S ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa) |
| | tuf | Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (422 aa) |
| | AGN01906.1 | Alanyl-tRNA synthetase, class IIc-like protein; COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain. (250 aa) |
| | AGN01915.1 | Methyltransferase; COG2520 Predicted methyltransferase. (402 aa) |
| | AGN01918.1 | Putative transcriptional regulator, BolA superfamily protein; COG0271 Stress-induced morphogen (activity unknown). (81 aa) |
| | hisS | COG0124 Histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (438 aa) |
| | truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family. (283 aa) |
| | rps7 | 30S ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (190 aa) |
| | rps12P | 30S ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (142 aa) |
| | tfb-4 | Transcription initiation factor TFIIIB, Brf1 subunit/transcription initiation factor TFIIB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (332 aa) |
| | eif2b | Translation initiation factor IF-2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (134 aa) |
| | rnp2 | Ribonuclease P subunit P14; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family. (177 aa) |
| | rnp3 | RNase P subunit p30; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family. (234 aa) |
| | AGN01978.1 | Transcription factor TFIIB cyclin-like protein; COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB. (102 aa) |
| | AGN01985.1 | COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (107 aa) |
| | rps17E | COG1383 Ribosomal protein S17E; Belongs to the eukaryotic ribosomal protein eS17 family. (62 aa) |
| | rpl11p | 50S ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (162 aa) |
| | AGN02075.1 | Prefoldin subunit alpha; COG1370 Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit. (167 aa) |
| | flpA | Fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (209 aa) |
| | AGN02098.1 | Transcription termination factor Tfs; COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (107 aa) |
| | AGN02099.1 | COG2519 tRNA(1-methyladenosine) methyltransferase and related methyltransferases. (249 aa) |
| | fau-1 | RNA-binding protein AU-1; Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences. (479 aa) |
| | AGN02130.1 | Hypothetical protein; COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control. (327 aa) |
| | rpl10e | COG0197 Ribosomal protein L16/L10E; Belongs to the universal ribosomal protein uL16 family. (176 aa) |
| | rpl3p | 50S ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (337 aa) |
| | rpl4lp | 50S ribosomal protein L4P; Forms part of the polypeptide exit tunnel. (249 aa) |
| | rpl23 | 50S ribosomal protein L23P; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (89 aa) |
| | rpl2p | 50S ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (240 aa) |
| | rps19p | 30S ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (141 aa) |
| | rpl22p | 50S ribosomal protein L22P; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (158 aa) |
| | rps3p | 30S ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (329 aa) |
| | rpl29 | COG0255 Ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (69 aa) |
| | rnp1 | Ribonuclease P protein component 1; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family. (136 aa) |
| | rps17p | 30S ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (115 aa) |
| | rpl14p | 50S ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (132 aa) |
| | rpl24p | 50S ribosomal protein L24P; Located at the polypeptide exit tunnel on the outside of the subunit. (120 aa) |
| | rps4e | COG1471 Ribosomal protein S4E; Belongs to the eukaryotic ribosomal protein eS4 family. (266 aa) |
| | rpl5p | 50S ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (172 aa) |
| | rps14P | 30S ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (61 aa) |
| | rps8p | 30S ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | rpl6p | COG0097 Ribosomal protein L6P/L9E. (199 aa) |
| | rpl32e | 50S ribosomal protein L32e; COG0468 RecA/RadA recombinase; Belongs to the eukaryotic ribosomal protein eL32 family. (326 aa) |
| | rpl19e | 50S ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (155 aa) |
| | rpl18p | 50S ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (181 aa) |
| | rps5p | 30S ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (216 aa) |
| | rpl30p | COG1841 Ribosomal protein L30/L7E. (154 aa) |
| | rpl15p | 50S ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (174 aa) |
| | endA | tRNA splicing endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. (347 aa) |
| | AGN02263.1 | Hypothetical protein. (137 aa) |
| | AGN02269.1 | Hypothetical protein; COG1522 Transcriptional regulators. (116 aa) |
| | infB | Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. (601 aa) |
| | rpl12p | 50S ribosomal protein L12P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (115 aa) |
| | rplP0 | Acidic ribosomal protein P0; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (353 aa) |
| | rpl1P | 50S ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (212 aa) |
| | AGN02359.1 | Protein synthesis factor GTP-binding protein; COG5258 GTPase. (568 aa) |
| | AGN02454.1 | COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins; Belongs to the SUI1 family. (97 aa) |
| | AGN02458.1 | COG1184 Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family; Belongs to the eIF-2B alpha/beta/delta subunits family. (283 aa) |
| | AGN02460.1 | Hypothetical protein. (166 aa) |
| | AGN02472.1 | Hypothetical protein; COG1326 Uncharacterized archaeal Zn-finger protein. (216 aa) |
| | rps6e | COG2125 Ribosomal protein S6E (S10); Belongs to the eukaryotic ribosomal protein eS6 family. (129 aa) |
| | AGN02499.1 | Hypothetical protein; COG0565 rRNA methylase. (259 aa) |
| | gatE | glutamyl-tRNA(Gln) amidotransferase subunit E; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (628 aa) |
| | thrS | COG0441 Threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (648 aa) |
| | AGN02549.1 | N-acetyltransferase GCN5; COG0454 Histone acetyltransferase HPA2 and related acetyltransferases. (164 aa) |
| | AGN02577.1 | Abortive infection protein; COG1266 Predicted metal-dependent membrane protease. (256 aa) |
| | AGN02579.1 | Hypothetical protein; COG1439 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module. (154 aa) |
| | AGN02582.1 | COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein. (82 aa) |
| | rnp4 | RNase P subunit RPR2; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (93 aa) |
| | AGN02586.1 | Deoxyribonuclease/rho motif-related TRAM; COG3269 Predicted RNA-binding protein, contains TRAM domain. (135 aa) |
| | rpl37e | 50S ribosomal protein L37e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (56 aa) |
