STRINGSTRING
AGN00107.1 AGN00107.1 AGN00110.1 AGN00110.1 leuC leuC ilvC ilvC AGN00114.1 AGN00114.1 AGN00115.1 AGN00115.1 AGN00116.1 AGN00116.1 AGN00442.1 AGN00442.1 AGN00445.1 AGN00445.1 AGN00521.1 AGN00521.1 AGN00541.1 AGN00541.1 AGN01112.1 AGN01112.1 ilvE ilvE AGN01522.1 AGN01522.1 argC argC lysZ lysZ lysJ lysJ lysK-2 lysK-2 AGN01675.1 AGN01675.1 AGN01717.1 AGN01717.1 ilvD ilvD AGN01814.1 AGN01814.1 AGN01862.1 AGN01862.1 AGN02025.1 AGN02025.1 AGN02395.1 AGN02395.1 AGN02557.1 AGN02557.1 AGN02615.1 AGN02615.1 AGN02780.1 AGN02780.1 AGN02789.1 AGN02789.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGN00107.1COG0473 Isocitrate/isopropylmalate dehydrogenase. (326 aa)
AGN00110.1COG0066 3-isopropylmalate dehydratase small subunit. (214 aa)
leuCIsopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (473 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (347 aa)
AGN00114.1COG0440 Acetolactate synthase, small (regulatory) subunit. (219 aa)
AGN00115.1Acetolactate synthase large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (629 aa)
AGN00116.1COG0119 Isopropylmalate/homocitrate/citramalate synthases. (345 aa)
AGN00442.1Acetolactate synthase large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (573 aa)
AGN00445.1N-acetyltransferase GCN5; COG1246 N-acetylglutamate synthase and related acetyltransferases. (159 aa)
AGN00521.1COG0538 Isocitrate dehydrogenases. (422 aa)
AGN00541.1COG0372 Citrate synthase. (377 aa)
AGN01112.1(R)-citramalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. (507 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (309 aa)
AGN01522.1COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase). (298 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (348 aa)
lysZAcetylglutamate/acetylaminoadipate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (299 aa)
lysJAcetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (382 aa)
lysK-2Acetyl-lysine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (372 aa)
AGN01675.1COG0527 Aspartokinases; Belongs to the aspartokinase family. (392 aa)
AGN01717.12-methylcitrate synthase/citrate synthase II; COG0372 Citrate synthase. (383 aa)
ilvDCOG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (580 aa)
AGN01814.1COG0436 Aspartate/tyrosine/aromatic aminotransferase. (378 aa)
AGN01862.1Aconitate hydratase; COG1048 Aconitase A. (657 aa)
AGN02025.1COG0136 Aspartate-semialdehyde dehydrogenase. (345 aa)
AGN02395.1Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (557 aa)
AGN02557.1COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (287 aa)
AGN02615.1COG0436 Aspartate/tyrosine/aromatic aminotransferase. (380 aa)
AGN02780.1COG0436 Aspartate/tyrosine/aromatic aminotransferase. (373 aa)
AGN02789.1COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (380 aa)
Your Current Organism:
Salinarchaeum sp. HarchtBsk1
NCBI taxonomy Id: 1333523
Other names: S. sp. Harcht-Bsk1, Salinarchaeum sp. Harcht-Bsk1
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