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AHY14418.1 AHY14418.1 lhgD lhgD AHY10136.1 AHY10136.1 serA serA AHY10390.1 AHY10390.1 dhaT dhaT gldA gldA garR garR mdh mdh fadB fadB wecC wecC ilvC ilvC aroE aroE glpD glpD AHY10906.1 AHY10906.1 AHY10910.1 AHY10910.1 AHY10916.1 AHY10916.1 ghrB ghrB dlgD dlgD yiaY yiaY mtlD mtlD lldD lldD gpsA gpsA tdh tdh AHY11261.1 AHY11261.1 AHY11282.1 AHY11282.1 metL metL gldA-2 gldA-2 murB murB AHY11661.1 AHY11661.1 AHY11663.1 AHY11663.1 AHY11691.1 AHY11691.1 AHY11696.1 AHY11696.1 AHY11721.1 AHY11721.1 AHY11722.1 AHY11722.1 thrA thrA pdxA pdxA leuB leuB pdxA-2 pdxA-2 AHY11892.1 AHY11892.1 ispC ispC ribD ribD panE panE AHY12343.1 AHY12343.1 AHY12420.1 AHY12420.1 AHY12645.1 AHY12645.1 ghrA ghrA fabG fabG AHY12932.1 AHY12932.1 AHY12983.1 AHY12983.1 AHY12985.1 AHY12985.1 AHY13071.1 AHY13071.1 AHY13115.1 AHY13115.1 AHY13163.1 AHY13163.1 AHY13275.1 AHY13275.1 ydfG ydfG uxaB uxaB AHY13327.1 AHY13327.1 maeA maeA AHY13407.1 AHY13407.1 ldhA ldhA AHY13445.1 AHY13445.1 AHY13608.1 AHY13608.1 AHY13693.1 AHY13693.1 g6pd g6pd AHY13959.1 AHY13959.1 hisD hisD AHY13988.1 AHY13988.1 gnd gnd fcl fcl dld dld AHY14139.1 AHY14139.1 mqo mqo glpA glpA glpB glpB arnA arnA pdxB pdxB fadJ fadJ AHY14428.1 AHY14428.1 guaB guaB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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AHY14418.1Ethanolamine utilization protein EutG; Aldehyde reductase; catalyzes the conversion of acetaldehyde to ethanol; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
lhgDHydroxyglutarate oxidase; Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Reaction=(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665; Belongs to the L2HGDH family. (422 aa)
AHY10136.11,2-propanediol oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
serAD-3-phosphoglycerate dehydrogenase; Catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa)
AHY10390.1Aldehyde reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
dhaT1,3-propanediol dehydrogenase; Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate; Belongs to the iron-containing alcohol dehydrogenase family. (387 aa)
gldAGlycerol dehydrogenase; Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions. Exhibits a rather broad substrate specificity since it can also oxidize 1,2-propanediol and 2,3-butanediol and reduce dihydroxyacetone. Cannot use NADP(+) as an electron acceptor for the oxidation of glycerol. (365 aa)
garRTartronate semialdehyde reductase; Catalyzes the reduction of tatronate semialdehyde to D- glycerate; Belongs to the HIBADH-related family. 2-hydroxy-3- oxopropionate reductase subfamily. (296 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa)
fadBMultifunctional fatty acid oxidation complex subunit alpha; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (729 aa)
wecCUDP-N-acetyl-D-mannosamine dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (273 aa)
glpDGlycerol-3-phosphate dehydrogenase; In Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (502 aa)
AHY10906.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
AHY10910.1FAD-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
AHY10916.1D-mannonate oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the mannitol dehydrogenase family. (490 aa)
ghrBBifunctional glyoxylate/hydroxypyruvate reductase B; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. (324 aa)
dlgD2,3-diketo-L-gulonate reductase; Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate. (332 aa)
yiaYAlcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
mtlDMannitol-1-phosphate 5-dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
lldDLactate dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (396 aa)
gpsAGlycerol-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (339 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa)
AHY11261.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (298 aa)
AHY11282.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
metLAspartate kinase; Multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; Derived by automated computational analysis using gene prediction method: Protein Homology. (810 aa)
gldA-2Glycerol dehydrogenase; Forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (342 aa)
AHY11661.1L-idonate 5-dehydrogenase; NAD-binding; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
AHY11663.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
AHY11691.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
AHY11696.1D-mannonate oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (491 aa)
AHY11721.1Galactonate oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (340 aa)
AHY11722.1Altronate oxidoreductase; Catalyzes the formation of D-tagaturonate from D-altronate; Derived by automated computational analysis using gene prediction method: Protein Homology. (481 aa)
thrAAspartate kinase; Multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; Derived by automated computational analysis using gene prediction method: Protein Homology. (820 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (330 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa)
pdxA-24-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)
AHY11892.1Quinoprotein glucose dehydrogenase; catalyzes the formation of D-glucono-1,5-lactone from D-glucose and ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology. (796 aa)
ispC1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). (398 aa)
ribD5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (367 aa)
panE2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (303 aa)
AHY12343.1Tartronate semialdehyde reductase; NADH-dependent; catalyzed the reversible formation of glycerate from tartronate semialdehyde; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
AHY12420.1Oxidoreductase; Member of the iron-containing alcohol dehydrogenase family; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa)
AHY12645.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
ghrABifunctional glyoxylate/hydroxypyruvate reductase A; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. (312 aa)
fabG3-ketoacyl-ACP reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa)
AHY12932.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa)
AHY12983.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
AHY12985.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
AHY13071.1Diacetylchitobiose-6-phosphate hydrolase; Catalyzes the fromation of N-acetyl-D-glucosamine and N-acetyl-D-glucosamine-6-phosphate from diacetylchitobiose-6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (451 aa)
AHY13115.1YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
AHY13163.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
AHY13275.1D-mannonate oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the mannitol dehydrogenase family. (488 aa)
ydfGMalonic semialdehyde reductase; NADP(+)-dependent; catalyzes the formation of 3-hydroxypropionate from the toxic malonic semialdehyde, catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa)
uxaBAltronate oxidoreductase; Catalyzes the formation of D-tagaturonate from D-altronate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the mannitol dehydrogenase family. UxaB subfamily. (483 aa)
AHY13327.13-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
maeANAD-dependent malic enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (565 aa)
AHY13407.1Catalyzes the formation of S-formylglutathione from S-(hydroxymethyl)glutathione; also catalyzes the formation of aldehyde or ketone from alcohols; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (372 aa)
ldhALactate dehydrogenase; Fermentative; catalyzes the formationof pyruvate from lactate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa)
AHY13445.1Hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
AHY13608.1Acetaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (892 aa)
AHY13693.1Tartrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (361 aa)
g6pdGlucose-6-phosphate dehydrogenase; Catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (491 aa)
AHY13959.1Propanediol utilization protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa)
AHY13988.1UDP-glucose 6-dehydrogenase; Catalyzes the formation of UDP-glucuronate from UDP-glucose; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
gnd6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
fclGDP-fucose synthetase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (321 aa)
dldLactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (569 aa)
AHY14139.1D-mannonate oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the mannitol dehydrogenase family. (488 aa)
mqoMalate:quinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (553 aa)
glpAGlycerol-3-phosphate dehydrogenase; Anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (542 aa)
glpBGlycerol-3-phosphate dehydrogenase; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor. (419 aa)
arnAUDP-4-amino-4-deoxy-L-arabinose formyltransferase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the N-terminal section; belongs to the Fmt family. UDP- L-Ara4N formyltransferase subfamily. (660 aa)
pdxBErythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (378 aa)
fadJMultifunctional fatty acid oxidation complex subunit alpha; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (715 aa)
AHY14428.1Malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (759 aa)
guaBInosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa)
Your Current Organism:
Citrobacter freundii
NCBI taxonomy Id: 1333848
Other names: C. freundii CFNIH1, Citrobacter freundii CFNIH1
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