STRINGSTRING
AKL17_0126 AKL17_0126 gpmI gpmI accA accA AKL17_0209 AKL17_0209 AKL17_0213 AKL17_0213 AKL17_0215 AKL17_0215 fbp fbp AKL17_0258 AKL17_0258 acsA acsA tal tal pckA pckA AKL17_0892 AKL17_0892 prs prs ackA ackA AKL17_1102 AKL17_1102 ldh ldh AKL17_1211 AKL17_1211 AKL17_1284 AKL17_1284 AKL17_1303 AKL17_1303 AKL17_1403 AKL17_1403 AKL17_1562 AKL17_1562 AKL17_1681 AKL17_1681 pgk pgk eno eno AKL17_1729 AKL17_1729 tpiA tpiA AKL17_1790 AKL17_1790 AKL17_1792 AKL17_1792 fumC fumC AKL17_1916 AKL17_1916 AKL17_1969 AKL17_1969 glcB glcB AKL17_1998 AKL17_1998 AKL17_1999 AKL17_1999 AKL17_2070 AKL17_2070 lipA lipA tal-2 tal-2 edd edd AKL17_2489 AKL17_2489 pgi pgi pgl pgl zwf zwf AKL17_2654 AKL17_2654 pdhA pdhA AKL17_2657 AKL17_2657 AKL17_2658 AKL17_2658 AKL17_2659 AKL17_2659 lipB lipB AKL17_2705 AKL17_2705 rpiA rpiA AKL17_2753 AKL17_2753 AKL17_2795 AKL17_2795 AKL17_2841 AKL17_2841 AKL17_3443 AKL17_3443 AKL17_3494 AKL17_3494 AKL17_3495 AKL17_3495 AKL17_3591 AKL17_3591 AKL17_3626 AKL17_3626 AKL17_3629 AKL17_3629 AKL17_3630 AKL17_3630 sucD sucD sucC sucC mdh mdh AKL17_3642 AKL17_3642 AKL17_3643 AKL17_3643 AKL17_3644 AKL17_3644 AKL17_3646 AKL17_3646 AKL17_4330 AKL17_4330 AKL17_4339 AKL17_4339 AKL17_4474 AKL17_4474 AKL17_4551 AKL17_4551 rbsK rbsK AKL17_4620 AKL17_4620 accD accD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKL17_0126Beta-ketothiolase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (506 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
AKL17_0209Ribulose-5-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (230 aa)
AKL17_0213Fructose-1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (359 aa)
AKL17_0215Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (659 aa)
fbpD-fructose 1,6-bisphosphatase; Belongs to the FBPase class 1 family. (341 aa)
AKL17_02586-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. (325 aa)
acsAacetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (684 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (532 aa)
AKL17_0892L-lactate dehydrogenase. (387 aa)
prsRibose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (339 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (392 aa)
AKL17_1102Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase. (460 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (310 aa)
AKL17_1211Putative D-lactate dehydrogenase, FAD/FMN-containing oxidoreductase. (461 aa)
AKL17_1284Glucokinase; Belongs to the bacterial glucokinase family. (324 aa)
AKL17_1303Hypothetical protein. (301 aa)
AKL17_1403Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
AKL17_1562Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (387 aa)
AKL17_1681Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (923 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (396 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
AKL17_1729Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (672 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa)
AKL17_1790Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
AKL17_1792Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)
AKL17_1916Ribulose-5-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (233 aa)
AKL17_1969Citrate -synthase; Belongs to the citrate synthase family. (431 aa)
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (720 aa)
AKL17_1998acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (162 aa)
AKL17_1999acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
AKL17_2070Phosphoglycerate/bisphosphoglycerate mutase. (201 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (319 aa)
tal-2Fructose-6-phosphate aldolase 1-like protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (681 aa)
AKL17_2489KHG/KDPG aldolase. (151 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (536 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (223 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (485 aa)
AKL17_2654Fructose-bisphosphate aldolase. (309 aa)
pdhAPyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (336 aa)
AKL17_2657Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (461 aa)
AKL17_2658Pyruvate dehydrogenase complex E2 component dihydrolipoyllysine-residue acetyltransferase. (158 aa)
AKL17_2659Branched-chain alpha-keto acid dehydrogenase subunit E2. (281 aa)
lipBLipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (214 aa)
AKL17_2705Pyruvate, phosphate dikinase. (856 aa)
rpiARibose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (262 aa)
AKL17_2753Fructose 1,6-bisphosphatase II. (321 aa)
AKL17_2795Dihydrolipoamide dehydrogenase. (465 aa)
AKL17_2841Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1148 aa)
AKL17_3443Malic enzyme. (774 aa)
AKL17_3494Pyruvate kinase; Belongs to the pyruvate kinase family. (354 aa)
AKL17_3495Pyruvate kinase. (140 aa)
AKL17_3591Pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa)
AKL17_3626Dihydrolipoamide dehydrogenase. (462 aa)
AKL17_3629Dihydrolipoamide acetyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (508 aa)
AKL17_36302-oxoglutarate dehydrogenase E1 component. (986 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
AKL17_3642Succinate dehydrogenase, cytochrome b subunit. (127 aa)
AKL17_3643Succinate dehydrogenase, hydrophobic membrane anchor protein. (123 aa)
AKL17_3644Succinate dehydrogenase; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (600 aa)
AKL17_3646Succinate dehydrogenase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (258 aa)
AKL17_43302,4-dienoyl-CoA reductase FadH1. (677 aa)
AKL17_4339Citrate synthase. (264 aa)
AKL17_4474AMP-dependent synthetase and ligase. (645 aa)
AKL17_4551Malate dehydrogenase. (755 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (292 aa)
AKL17_4620Phosphoglucomutase. (519 aa)
accDAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (317 aa)
Your Current Organism:
Defluviimonas alba
NCBI taxonomy Id: 1335048
Other names: CGMCC 1.12518, D. alba, Defluviimonas alba Pan et al. 2015, LMG 27406, LMG:27406, Rhodobacter sp. b45, Rhodobacter sp. cai42, strain cai42
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.