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rppH rppH AKL17_0130 AKL17_0130 AKL17_0131 AKL17_0131 rlmH rlmH rsfS rsfS AKL17_0135 AKL17_0135 prmA prmA miaB miaB rimO rimO AKL17_1852 AKL17_1852 mnmA mnmA AKL17_2836 AKL17_2836 AKL17_4222 AKL17_4222 AKL17_4244 AKL17_4244 AKL17_4543 AKL17_4543 AKL17_4544 AKL17_4544 AKL17_4545 AKL17_4545 AKL17_4546 AKL17_4546 rph rph
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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rppHDinucleoside polyphosphate hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. (161 aa)
AKL17_0130S41 family peptidase; Belongs to the peptidase S41A family. (447 aa)
AKL17_0131M23 family peptidase. (393 aa)
rlmHrRNA large subunit methyltransferase; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (154 aa)
rsfSIojap-related protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (124 aa)
AKL17_0135Hypothetical protein. (74 aa)
prmARibosomal protein L11 methyltransferase, putative; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. (291 aa)
miaBAdenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (460 aa)
rimORibosomal protein S12 methylthiotransferase; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (460 aa)
AKL17_1852SirA family protein; Belongs to the sulfur carrier protein TusA family. (75 aa)
mnmAtRNA-specific 2-thiouridylase MnmA; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (381 aa)
AKL17_2836Septum formation inhibitor-activating ATPase-like protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (364 aa)
AKL17_422216S ribosomal RNA methyltransferase RsmE. (188 aa)
AKL17_4244MiaB-like radical SAM protein. (419 aa)
AKL17_4543Hypothetical protein. (117 aa)
AKL17_4544Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (383 aa)
AKL17_4545YjgF family translation initiation inhibitor. (111 aa)
AKL17_4546Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (202 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (237 aa)
Your Current Organism:
Defluviimonas alba
NCBI taxonomy Id: 1335048
Other names: CGMCC 1.12518, D. alba, Defluviimonas alba Pan et al. 2015, LMG 27406, LMG:27406, Rhodobacter sp. b45, Rhodobacter sp. cai42, strain cai42
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