STRINGSTRING
AKL17_3629 AKL17_3629 AKL17_0003 AKL17_0003 AKL17_0053 AKL17_0053 rppH rppH gpmI gpmI accA accA purU purU acsA acsA adk adk AKL17_0374 AKL17_0374 adk-2 adk-2 atpB atpB atpE atpE atpF atpF atpF-2 atpF-2 AKL17_0619 AKL17_0619 AKL17_0656 AKL17_0656 AKL17_0793 AKL17_0793 atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC prs prs AKL17_0942 AKL17_0942 purK purK purE purE ackA ackA AKL17_1102 AKL17_1102 AKL17_1106 AKL17_1106 AKL17_1150 AKL17_1150 carB carB AKL17_1243 AKL17_1243 AKL17_1284 AKL17_1284 AKL17_1298 AKL17_1298 AKL17_1303 AKL17_1303 purM purM purN purN guaA guaA gpt gpt AKL17_1607 AKL17_1607 pgk pgk eno eno AKL17_1701 AKL17_1701 purL purL tpiA tpiA coaD coaD purQ purQ gmk gmk pyrH pyrH AKL17_1999 AKL17_1999 purS purS purC purC AKL17_2021 AKL17_2021 AKL17_2070 AKL17_2070 AKL17_2104 AKL17_2104 guaB guaB phnN phnN pyrC pyrC pyrE pyrE purF purF surE surE coaX coaX ndk ndk AKL17_2481 AKL17_2481 pgi pgi AKL17_2521 AKL17_2521 AKL17_2651 AKL17_2651 AKL17_2654 AKL17_2654 pdhA pdhA AKL17_2657 AKL17_2657 AKL17_2658 AKL17_2658 AKL17_2659 AKL17_2659 carA carA purD purD purU-2 purU-2 purA purA pyrG pyrG AKL17_2960 AKL17_2960 AKL17_3104 AKL17_3104 AKL17_3236 AKL17_3236 AKL17_3417 AKL17_3417 upp upp deoB deoB AKL17_3445 AKL17_3445 AKL17_3494 AKL17_3494 AKL17_3495 AKL17_3495 apt apt AKL17_3591 AKL17_3591 AKL17_3598 AKL17_3598 AKL17_3630 AKL17_3630 AKL17_3637 AKL17_3637 AKL17_3899 AKL17_3899 pyrF pyrF purH purH pyrB pyrB amn amn AKL17_4474 AKL17_4474 coaE coaE accD accD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKL17_3629Dihydrolipoamide acetyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (508 aa)
AKL17_0003Putative phosphatase. (145 aa)
AKL17_0053Phosphoglycerate mutase. (143 aa)
rppHDinucleoside polyphosphate hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. (161 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (506 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
acsAacetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (684 aa)
adkAdenylate kinases; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (230 aa)
AKL17_0374ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (705 aa)
adk-2Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (222 aa)
atpBF0F1 ATP synthase subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (249 aa)
atpEATP synthase F0 subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (77 aa)
atpFF0F1 ATP synthase subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (191 aa)
atpF-2F0F1 ATP synthase subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (185 aa)
AKL17_0619Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa)
AKL17_0656Dihydroorotate dehydrogenase. (358 aa)
AKL17_0793Flagellar protein export ATPase FliI. (457 aa)
atpHATPase, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (186 aa)
atpAF0F1 ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (512 aa)
atpGF0F1 ATP synthase subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (289 aa)
atpDF0F1 ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (474 aa)
atpCATP synthase F1 subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (143 aa)
prsRibose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (339 aa)
AKL17_0942FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. (308 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (361 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (161 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (392 aa)
AKL17_1102Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase. (460 aa)
AKL17_1106Antibiotic biosynthesis monooxygenase domain-containing protein. (105 aa)
AKL17_1150Selenophosphate synthetase-related protein. (327 aa)
carBCarbamoyl phosphate synthase large subunit; Belongs to the CarB family. (1109 aa)
AKL17_1243Bleomycin resistance protein. (128 aa)
AKL17_1284Glucokinase; Belongs to the bacterial glucokinase family. (324 aa)
AKL17_1298Hypothetical protein. (296 aa)
AKL17_1303Hypothetical protein. (301 aa)
purMPhosphoribosylaminoimidazole synthetase. (348 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (198 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (518 aa)
gptXanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (167 aa)
AKL17_1607Citrate lyase, beta subunit, putative; Belongs to the HpcH/HpaI aldolase family. (265 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (396 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
AKL17_1701Nucleoside triphosphate pyrophosphohydrolase. (279 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (723 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (167 aa)
purQPhosphoribosylformylglycinamidine synthase subunit PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (222 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (218 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (247 aa)
AKL17_1999acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
purSPhosphoribosylformylglycinamidine synthase subunit PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (79 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (254 aa)
AKL17_2021ADP-ribose pyrophosphatase. (380 aa)
AKL17_2070Phosphoglycerate/bisphosphoglycerate mutase. (201 aa)
AKL17_2104Glyoxalase/bleomycin resistance protein/dioxygenase. (124 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (482 aa)
phnNAlkylphosphonate utilization protein PhnN; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (184 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (347 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (225 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (486 aa)
surEStationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (261 aa)
coaXPantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (259 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
AKL17_2481Hypothetical protein. (201 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (536 aa)
AKL17_2521Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (186 aa)
AKL17_2651Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa)
AKL17_2654Fructose-bisphosphate aldolase. (309 aa)
pdhAPyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (336 aa)
AKL17_2657Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (461 aa)
AKL17_2658Pyruvate dehydrogenase complex E2 component dihydrolipoyllysine-residue acetyltransferase. (158 aa)
AKL17_2659Branched-chain alpha-keto acid dehydrogenase subunit E2. (281 aa)
carACarbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (388 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (420 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (547 aa)
AKL17_2960DNA topology modulation kinase FlaR, putative. (170 aa)
AKL17_3104Thioesterase superfamily protein. (167 aa)
AKL17_3236Riboflavin biosynthesis protein RibF. (260 aa)
AKL17_3417Dihydroorotate dehydrogenase 2; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (353 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (210 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (407 aa)
AKL17_3445acyl-CoA sythetase. (631 aa)
AKL17_3494Pyruvate kinase; Belongs to the pyruvate kinase family. (354 aa)
AKL17_3495Pyruvate kinase. (140 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (195 aa)
AKL17_3591Pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa)
AKL17_3598Citrate -lyase; Belongs to the HpcH/HpaI aldolase family. (318 aa)
AKL17_36302-oxoglutarate dehydrogenase E1 component. (986 aa)
AKL17_3637Citrate -lyase; Belongs to the HpcH/HpaI aldolase family. (290 aa)
AKL17_3899Dihydropyrimidine dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (322 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (243 aa)
purHBifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (528 aa)
pyrBAspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (320 aa)
amnAMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (494 aa)
AKL17_4474AMP-dependent synthetase and ligase. (645 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (198 aa)
accDAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (317 aa)
Your Current Organism:
Defluviimonas alba
NCBI taxonomy Id: 1335048
Other names: CGMCC 1.12518, D. alba, Defluviimonas alba Pan et al. 2015, LMG 27406, LMG:27406, Rhodobacter sp. b45, Rhodobacter sp. cai42, strain cai42
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.