node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKL17_0200 | AKL17_0201 | AKL17_0200 | AKL17_0201 | glyA-3. | Hypothetical protein. | 0.773 |
AKL17_0200 | AKL17_2635 | AKL17_0200 | AKL17_2635 | glyA-3. | 5,10-methylenetetrahydrofolate reductase. | 0.928 |
AKL17_0200 | AKL17_3029 | AKL17_0200 | AKL17_3029 | glyA-3. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.928 |
AKL17_0200 | fhs | AKL17_0200 | AKL17_3549 | glyA-3. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.955 |
AKL17_0200 | folD | AKL17_0200 | AKL17_3547 | glyA-3. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.962 |
AKL17_0200 | glyA | AKL17_0200 | AKL17_3452 | glyA-3. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.923 |
AKL17_0201 | AKL17_0200 | AKL17_0201 | AKL17_0200 | Hypothetical protein. | glyA-3. | 0.773 |
AKL17_0201 | fhs | AKL17_0201 | AKL17_3549 | Hypothetical protein. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.584 |
AKL17_0201 | folD | AKL17_0201 | AKL17_3547 | Hypothetical protein. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.664 |
AKL17_2635 | AKL17_0200 | AKL17_2635 | AKL17_0200 | 5,10-methylenetetrahydrofolate reductase. | glyA-3. | 0.928 |
AKL17_2635 | AKL17_3029 | AKL17_2635 | AKL17_3029 | 5,10-methylenetetrahydrofolate reductase. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.937 |
AKL17_2635 | folD | AKL17_2635 | AKL17_3547 | 5,10-methylenetetrahydrofolate reductase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.924 |
AKL17_2635 | glyA | AKL17_2635 | AKL17_3452 | 5,10-methylenetetrahydrofolate reductase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.932 |
AKL17_2883 | AKL17_2884 | AKL17_2883 | AKL17_2884 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 5-formyltetrahydrofolate cyclo-ligase. | 0.773 |
AKL17_2883 | folD | AKL17_2883 | AKL17_3547 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.924 |
AKL17_2884 | AKL17_2883 | AKL17_2884 | AKL17_2883 | 5-formyltetrahydrofolate cyclo-ligase. | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.773 |
AKL17_3029 | AKL17_0200 | AKL17_3029 | AKL17_0200 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | glyA-3. | 0.928 |
AKL17_3029 | AKL17_2635 | AKL17_3029 | AKL17_2635 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 5,10-methylenetetrahydrofolate reductase. | 0.937 |
AKL17_3029 | fhs | AKL17_3029 | AKL17_3549 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.470 |
AKL17_3029 | folD | AKL17_3029 | AKL17_3547 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.949 |