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| | AKL17_0034 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding subunit. (319 aa) |
| | AKL17_0092 | Pyridoxal-5'-phosphate-dependent protein subunit beta. (374 aa) |
| | AKL17_0119 | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (384 aa) |
| | AKL17_0120 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (531 aa) |
| | AKL17_0126 | Beta-ketothiolase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (506 aa) |
| | AKL17_0160 | acetoacetyl-CoA reductase. (240 aa) |
| | AKL17_0161 | acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | AKL17_0188 | Threonine dehydratase. (232 aa) |
| | AKL17_0200 | glyA-3. (396 aa) |
| | AKL17_0206 | Putative catalase; Serves to protect cells from the toxic effects of hydrogen peroxide. (705 aa) |
| | AKL17_0209 | Ribulose-5-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (230 aa) |
| | AKL17_0211 | Ribulose 1,5-bisphosphate carboxylase small subunit. (128 aa) |
| | cbbL | Ribulose bisophosphate carboxylase; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site; Belongs to the RuBisCO large chain family. Type I subfamily. (485 aa) |
| | AKL17_0213 | Fructose-1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (359 aa) |
| | AKL17_0214 | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa) |
| | AKL17_0215 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (659 aa) |
| | AKL17_0216 | Phosphoribulokinase. (290 aa) |
| | fbp | D-fructose 1,6-bisphosphatase; Belongs to the FBPase class 1 family. (341 aa) |
| | AKL17_0241 | Glycine cleavage system T protein; Belongs to the GcvT family. (793 aa) |
| | AKL17_0243 | Sarcosine oxidase alpha subunit; Belongs to the GcvT family. (375 aa) |
| | AKL17_0258 | 6-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. (325 aa) |
| | acsA | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (684 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa) |
| | AKL17_0387 | acyl-CoA dehydrogenase domain-containing protein. (556 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (532 aa) |
| | AKL17_0396 | 3-hydroxybutyryl-CoA dehydrogenase. (291 aa) |
| | AKL17_0582 | Aminomethyltransferase protein; Belongs to the GcvT family. (350 aa) |
| | gfa | Glutathione-dependent formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione; Belongs to the Gfa family. (193 aa) |
| | AKL17_0666 | Alcohol dehydrogenase class III; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (376 aa) |
| | AKL17_0667 | S-formylglutathione hydrolase, putative; Serine hydrolase involved in the detoxification of formaldehyde. (280 aa) |
| | AKL17_0807 | Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa) |
| | AKL17_0822 | Formate dehydrogenase subunit gamma. (156 aa) |
| | AKL17_0823 | NAD dependent formate dehydrogenase, beta subunit. (509 aa) |
| | AKL17_0824 | NAD-dependent formate dehydrogenase, alpha subunit. (959 aa) |
| | AKL17_0867 | Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (177 aa) |
| | AKL17_0910 | methylmalonyl-CoA mutase large subunit. (656 aa) |
| | AKL17_0912 | crotonyl-CoA reductase. (430 aa) |
| | prs | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (339 aa) |
| | AKL17_0943 | MaoC domain-containing protein dehydratase. (149 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (392 aa) |
| | AKL17_1163 | methylmalonyl-CoA epimerase. (134 aa) |
| | AKL17_1284 | Glucokinase; Belongs to the bacterial glucokinase family. (324 aa) |
| | AKL17_1403 | Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa) |
| | AKL17_1421 | Putative trimethylamine methyltransferase protein; Belongs to the trimethylamine methyltransferase family. (451 aa) |
| | AKL17_1608 | Hypothetical protein. (279 aa) |
| | AKL17_1644 | Hydroxypyruvate reductase. (443 aa) |
| | AKL17_1645 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein. (331 aa) |
| | AKL17_1681 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (923 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (396 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa) |
| | AKL17_1729 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (672 aa) |
| | AKL17_1748 | 3-hydroxybutyryl-CoA epimerase. (655 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa) |
| | AKL17_1784 | Methylmalonate-semialdehyde dehydrogenase. (499 aa) |
| | AKL17_1790 | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa) |
| | AKL17_1792 | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa) |
| | fumC | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa) |
| | AKL17_1916 | Ribulose-5-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (233 aa) |
| | AKL17_1969 | Citrate -synthase; Belongs to the citrate synthase family. (431 aa) |
| | glcB | Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (720 aa) |
| | AKL17_1998 | acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (162 aa) |
| | AKL17_1999 | acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa) |
| | AKL17_2020 | Cysteine synthase A. (343 aa) |
| | AKL17_2070 | Phosphoglycerate/bisphosphoglycerate mutase. (201 aa) |
| | AKL17_2099 | Catalase. (488 aa) |
| | tal-2 | Fructose-6-phosphate aldolase 1-like protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa) |
| | AKL17_2390 | methylmalonyl-CoA mutase. (714 aa) |
| | AKL17_2393 | propionyl-CoA carboxylase alpha subunit. (666 aa) |
| | AKL17_2399 | Carboxyl transferase. (510 aa) |
| | edd | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (681 aa) |
| | AKL17_2489 | KHG/KDPG aldolase. (151 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (536 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (223 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (485 aa) |
| | AKL17_2635 | 5,10-methylenetetrahydrofolate reductase. (305 aa) |
| | AKL17_2654 | Fructose-bisphosphate aldolase. (309 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (336 aa) |
| | AKL17_2657 | Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (461 aa) |
| | AKL17_2659 | Branched-chain alpha-keto acid dehydrogenase subunit E2. (281 aa) |
| | AKL17_2661 | Serine O-acetyltransferase. (268 aa) |
| | AKL17_2705 | Pyruvate, phosphate dikinase. (856 aa) |
| | rpiA | Ribose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (262 aa) |
| | AKL17_2739 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (459 aa) |
| | AKL17_2745 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (476 aa) |
| | AKL17_2753 | Fructose 1,6-bisphosphatase II. (321 aa) |
| | AKL17_2768 | Trimethylamine methyltransferase family protein; Belongs to the trimethylamine methyltransferase family. (523 aa) |
| | AKL17_2795 | Dihydrolipoamide dehydrogenase. (465 aa) |
| | AKL17_2841 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1148 aa) |
| | gcvP | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (945 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (119 aa) |
| | AKL17_2921 | Glycine cleavage T protein. (374 aa) |
| | AKL17_2948 | Glyceraldehyde-3-phosphate dehydrogenase-4; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa) |
| | AKL17_3029 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (288 aa) |
| | AKL17_3039 | Serine--glyoxylate transaminase. (399 aa) |
| | AKL17_3095 | 3-hydroxyacyl-CoA dehydrogenase / short chain enoyl-CoA hydratase. (648 aa) |
| | AKL17_3096 | 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa) |
| | AKL17_3103 | Phosphoserine phosphatase SerB. (299 aa) |
| | AKL17_3189 | Hydroxypyruvate reductase. (221 aa) |
| | AKL17_3274 | 2-dehydro-3-deoxygluconokinase. (240 aa) |
| | AKL17_3427 | acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa) |
| | AKL17_3430 | 3-hydroxyacyl-CoA dehydrogenase NAD-binding. (458 aa) |
| | AKL17_3443 | Malic enzyme. (774 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa) |
| | AKL17_3494 | Pyruvate kinase; Belongs to the pyruvate kinase family. (354 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (296 aa) |
| | fhs | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (572 aa) |
| | AKL17_3591 | Pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa) |
| | AKL17_3598 | Citrate -lyase; Belongs to the HpcH/HpaI aldolase family. (318 aa) |
| | AKL17_3626 | Dihydrolipoamide dehydrogenase. (462 aa) |
| | AKL17_3629 | Dihydrolipoamide acetyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (508 aa) |
| | AKL17_3630 | 2-oxoglutarate dehydrogenase E1 component. (986 aa) |
| | sucD | succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa) |
| | sucC | succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa) |
| | AKL17_3637 | Citrate -lyase; Belongs to the HpcH/HpaI aldolase family. (290 aa) |
| | AKL17_3640 | MaoC domain-containing protein. (343 aa) |
| | AKL17_3642 | Succinate dehydrogenase, cytochrome b subunit. (127 aa) |
| | AKL17_3643 | Succinate dehydrogenase, hydrophobic membrane anchor protein. (123 aa) |
| | AKL17_3644 | Succinate dehydrogenase; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (600 aa) |
| | AKL17_3646 | Succinate dehydrogenase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (258 aa) |
| | AKL17_3817 | Fatty acid oxidation complex subunit alpha 3. (533 aa) |
| | AKL17_4339 | Citrate synthase. (264 aa) |
| | AKL17_4341 | Putative cytosolic protein. (296 aa) |
| | AKL17_4463 | Biotin carboxylase. (489 aa) |
| | AKL17_4474 | AMP-dependent synthetase and ligase. (645 aa) |
| | AKL17_4551 | Malate dehydrogenase. (755 aa) |
| | ilvA | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (415 aa) |
| | AKL17_4662 | acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa) |
| | AKL17_4687 | Alcohol dehydrogenase class III; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (376 aa) |
| | AKL17_4695 | S-formylglutathione hydrolase, putative; Serine hydrolase involved in the detoxification of formaldehyde. (277 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (317 aa) |
