STRINGSTRING
hisH hisH hisF hisF AGY91144.1 AGY91144.1 AGY91145.1 AGY91145.1 AGY91148.1 AGY91148.1 AGY91151.1 AGY91151.1 AGY91152.1 AGY91152.1 AGY91213.1 AGY91213.1 pyrE pyrE AGY91297.1 AGY91297.1 AGY91316.1 AGY91316.1 AGY91363.1 AGY91363.1 trpD trpD AGY91423.1 AGY91423.1 AGY91491.1 AGY91491.1 queA queA tgt tgt AGY91625.1 AGY91625.1 AGY91719.1 AGY91719.1 AGY91802.1 AGY91802.1 mltG mltG AGY91919.1 AGY91919.1 lpxB lpxB AGY92241.1 AGY92241.1 AGY92322.1 AGY92322.1 AGY92323.1 AGY92323.1 AGY92378.1 AGY92378.1 purF purF murG murG ftsW ftsW ftsI ftsI hisG hisG mrdB mrdB rlpA rlpA deoD deoD AGY91025.1 AGY91025.1 AGY92607.1 AGY92607.1 AGY92620.1 AGY92620.1 AGY92624.1 AGY92624.1 AGY92629.1 AGY92629.1 AGY92688.1 AGY92688.1 AGY92717.1 AGY92717.1 apt apt AGY92750.1 AGY92750.1 lgt lgt
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hisHHypothetical protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (211 aa)
hisFImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa)
AGY91144.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (349 aa)
AGY91145.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (365 aa)
AGY91148.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (359 aa)
AGY91151.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (371 aa)
AGY91152.1Hypothetical protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (371 aa)
AGY91213.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (361 aa)
pyrEHypothetical protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (216 aa)
AGY91297.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (321 aa)
AGY91316.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (786 aa)
AGY91363.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (170 aa)
trpDHypothetical protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (340 aa)
AGY91423.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the multicopper oxidase YfiH/RL5 family. (256 aa)
AGY91491.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (751 aa)
queAHypothetical protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (347 aa)
tgtHypothetical protein; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. [...] (369 aa)
AGY91625.1Hypothetical protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (444 aa)
AGY91719.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the NadC/ModD family. (287 aa)
AGY91802.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (385 aa)
mltGHypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (339 aa)
AGY91919.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (191 aa)
lpxBHypothetical protein; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (385 aa)
AGY92241.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (618 aa)
AGY92322.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (358 aa)
AGY92323.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (267 aa)
AGY92378.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (536 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (497 aa)
murGHypothetical protein; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (374 aa)
ftsWHypothetical protein; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (399 aa)
ftsIHypothetical protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. (574 aa)
hisGHypothetical protein; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (214 aa)
mrdBHypothetical protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (387 aa)
rlpAHypothetical protein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (264 aa)
deoDHypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (348 aa)
AGY91025.1Bactoprenol glucosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
AGY92607.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (523 aa)
AGY92620.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (1181 aa)
AGY92624.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (378 aa)
AGY92629.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (401 aa)
AGY92688.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (458 aa)
AGY92717.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (432 aa)
aptHypothetical protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
AGY92750.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (804 aa)
lgtHypothetical protein; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (265 aa)
Your Current Organism:
Spiribacter curvatus
NCBI taxonomy Id: 1335757
Other names: Arhodomonas sp. SP71, CECT 8396, DSM 28542, S. curvatus, Spiribacter curvatus Leon et al. 2015, Spiribacter sp. UAH-SP71, strain UAH-SP71
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