(19 nodes) Purine metabolism network (Mesoplasma chauliocola)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

gene neighborhood

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Your Input:
	CK556_00960	Unannotated protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (158 aa)
	pyk	Unannotated protein; Belongs to the pyruvate kinase family. (269 aa)
	gmk	Unannotated protein; Essential for recycling GMP and indirectly, cGMP. (218 aa)
	apt	Unannotated protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
	CK556_01515	Unannotated protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (362 aa)
	guaA	Unannotated protein; Catalyzes the synthesis of GMP from XMP. (163 aa)
	CK556_01885	Unannotated protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (376 aa)
	CK556_02065	Unannotated protein. (102 aa)
	adk	Unannotated protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (212 aa)
	CK556_00675	Unannotated protein. (70 aa)
	prs	Unannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (167 aa)
	CK556_00450	Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (106 aa)
	purA	Unannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (288 aa)
	CK556_03005	Unannotated protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (487 aa)
	nrdF	Unannotated protein. (160 aa)
	CK556_03100	Unannotated protein. (157 aa)
	CK556_03105	Unannotated protein. (157 aa)
	deoD	Unannotated protein. (234 aa)
	hpt	Unannotated protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (149 aa)

Your Current Organism:

Mesoplasma chauliocola

NCBI taxonomy Id: 1336232
Other names: M. chauliocola ATCC 49578, Mesoplasma chauliocola ATCC 49578

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CK556_00450	CK556_02065	GCA_000518825_00600	GCA_000518825_00415	Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Unannotated protein.	0.403
CK556_00450	CK556_03100	GCA_000518825_00600	GCA_000518825_00916	Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Unannotated protein.	0.906
CK556_00450	CK556_03105	GCA_000518825_00600	GCA_000518825_00917	Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Unannotated protein.	0.906
CK556_00450	adk	GCA_000518825_00600	GCA_000518825_00483	Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Unannotated protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	0.953
CK556_00450	apt	GCA_000518825_00600	GCA_000518825_00221	Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Unannotated protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.962
CK556_00450	gmk	GCA_000518825_00600	GCA_000518825_00047	Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Unannotated protein; Essential for recycling GMP and indirectly, cGMP.	0.449
CK556_00450	guaA	GCA_000518825_00600	GCA_000518825_00343	Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Unannotated protein; Catalyzes the synthesis of GMP from XMP.	0.611
CK556_00450	prs	GCA_000518825_00600	GCA_000518825_00599	Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Unannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.	0.811
CK556_00450	purA	GCA_000518825_00600	GCA_000518825_00605	Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Unannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.980
CK556_00675	prs	GCA_000518825_00518	GCA_000518825_00599	Unannotated protein.	Unannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.	0.934
CK556_00960	CK556_01885	GCA_000518825_00004	GCA_000518825_00344	Unannotated protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.	Unannotated protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.900
CK556_00960	CK556_02065	GCA_000518825_00004	GCA_000518825_00415	Unannotated protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.	Unannotated protein.	0.451
CK556_00960	apt	GCA_000518825_00004	GCA_000518825_00221	Unannotated protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.	Unannotated protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.935
CK556_00960	gmk	GCA_000518825_00004	GCA_000518825_00047	Unannotated protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.	Unannotated protein; Essential for recycling GMP and indirectly, cGMP.	0.919
CK556_00960	guaA	GCA_000518825_00004	GCA_000518825_00343	Unannotated protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.	Unannotated protein; Catalyzes the synthesis of GMP from XMP.	0.995
CK556_00960	hpt	GCA_000518825_00004	GCA_000518825_01210	Unannotated protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.	Unannotated protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.923
CK556_00960	purA	GCA_000518825_00004	GCA_000518825_00605	Unannotated protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.	Unannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.968
CK556_01515	CK556_03005	GCA_000518825_00223	GCA_000518825_00881	Unannotated protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	Unannotated protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.904
CK556_01515	apt	GCA_000518825_00223	GCA_000518825_00221	Unannotated protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	Unannotated protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.422
CK556_01515	gmk	GCA_000518825_00223	GCA_000518825_00047	Unannotated protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	Unannotated protein; Essential for recycling GMP and indirectly, cGMP.	0.924