STRINGSTRING
fba fba lacC_1 lacC_1 pfkA pfkA pyk pyk ribF ribF prs2 prs2 yjbM yjbM coaBC_2 coaBC_2 coaBC_1 coaBC_1 zwf zwf ARC27377.1 ARC27377.1 cobQ cobQ ARC27379.1 ARC27379.1 disA disA udk udk murB murB ARC26494.1 ARC26494.1 MvaD MvaD ARC27422.1 ARC27422.1 rpe rpe glpK glpK pgi pgi purA purA ntpD ntpD ntpB ntpB ntpA ntpA ARC26583.1 ARC26583.1 murR murR murQ murQ rpiR rpiR nanE nanE oatA oatA lacD lacD agaS agaS purB purB purK purK purE purE purD purD ARC26653.1 ARC26653.1 purH purH purN purN purM purM purF purF purC purC prs prs tpiA_2 tpiA_2 guaB guaB dltA dltA patA_1 patA_1 dltC dltC DltD DltD pflA_2 pflA_2 cap8A cap8A pglD pglD A6J72_06130 A6J72_06130 glvR glvR tgt tgt adk adk gtaB gtaB gpsA gpsA dut dut pgk pgk ackA ackA glmS glmS tkt tkt fgs_2 fgs_2 queH queH relA relA fcl fcl ARC26971.1 ARC26971.1 hepC hepC gpmA_1 gpmA_1 pyrG_2 pyrG_2 gutB gutB deoD_2 deoD_2 A6J72_07980 A6J72_07980 ARC27108.1 ARC27108.1 pksG pksG pyrDA pyrDA fabZ fabZ accC accC accD accD accA accA nagA nagA mraY mraY pyrG_1 pyrG_1 apt apt uppP uppP dacA_1 dacA_1 gmk gmk coaD coaD murD murD murG murG murE murE upp upp tmk tmk glmU glmU nudF nudF mtnN mtnN pyrH pyrH queA queA nagB nagB dacA_2 dacA_2 femA femA ARC26152.1 ARC26152.1 pgl pgl ARC27412.1 ARC27412.1 ARC26104.1 ARC26104.1 pspB pspB A6J72_01960 A6J72_01960 ARC26073.1 ARC26073.1 tpiA_1 tpiA_1 rpiA rpiA punA punA deoD_1 deoD_1 ltaS2 ltaS2 ARC27405.1 ARC27405.1 rmlD rmlD rfbC rfbC rmlB rmlB thyA thyA ndk ndk pyrB pyrB carA carA carB carB glcK glcK FlaR FlaR coaA coaA deoA deoA deoC1 deoC1 cdd cdd eno eno ldhA ldhA xpt xpt ARC25877.1 ARC25877.1 guaA guaA nrdD_1 nrdD_1 ARC25842.1 ARC25842.1 murAB murAB pyrC pyrC coaE coaE pyrE pyrE pyrF pyrF pyrDB pyrDB pyrK pyrK mvaA mvaA gnd gnd murC murC mltG mltG murI murI bcrC bcrC ARC27164.1 ARC27164.1 gpmA_2 gpmA_2 penA penA ddl ddl murF murF lacD2 lacD2 lacC_2 lacC_2 ARC27228.1 ARC27228.1 atpE atpE atpB atpB atpF atpF atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC murAA murAA ARC27266.1 ARC27266.1 ARC27270.1 ARC27270.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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fbaFructose-1,6-bisphosphate aldolase, class II; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
lacC_1DeoR family transcriptional regulator; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (297 aa)
pfkAATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (336 aa)
pykPyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (500 aa)
ribFRiboflavin biosynthesis protein RibF; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (310 aa)
prs2Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (323 aa)
yjbMGTP pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
coaBC_2Phosphopantothenoylcysteine decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
coaBC_1Phosphopantothenate--cysteine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
zwfSpore gernimation protein GerA; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (495 aa)
ARC27377.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (80 aa)
cobQGlutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa)
ARC27379.1UDP-N-acetylmuramyl peptide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (447 aa)
disATIGR00159 family protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (285 aa)
udkUridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (300 aa)
ARC26494.1Phosphomevalonate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
MvaDDiphosphomevalonate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
ARC27422.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
rpeRibulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (219 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (503 aa)
pgiGlucose-6-phosphate isomerase; Functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (449 aa)
purARestriction endonuclease; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
ntpDV-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (207 aa)
ntpBV-type ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (463 aa)
ntpAV-type ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (596 aa)
ARC26583.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (196 aa)
murRMurR/RpiR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
murQN-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (308 aa)
rpiRRpiR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
nanEN-acetylmannosamine-6-phosphate 2-epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (234 aa)
oatAAcetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (605 aa)
lacDTagatose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldolase LacD family. (333 aa)
agaSTagatose-6-phosphate ketose isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
purBAdenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (363 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (420 aa)
ARC26653.1Amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (642 aa)
purHBifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (516 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (184 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (479 aa)
purCPhosphoribosylaminoimidazolesuccinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (235 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (322 aa)
tpiA_2Triose-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (493 aa)
dltAD-alanine--poly(phosphoribitol) ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-de [...] (516 aa)
patA_1D-alanyl-lipoteichoic acid biosynthesis protein DltB; Could be involved in the transport of activated D-alanine through the membrane. (430 aa)
dltCD-alanine--poly(phosphoribitol) ligase subunit 2; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. (79 aa)
DltDD-alanyl-lipoteichoic acid biosynthesis protein DltD; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
pflA_2Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (201 aa)
cap8ACapsular biosynthesis protein CpsC; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
pglDHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (207 aa)
A6J72_06130Phosphoglycerate mutase; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (846 aa)
glvRMurR/RpiR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
tgttRNA guanosine(34) transglycosylase Tgt; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose t [...] (380 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (212 aa)
gtaBUTP--glucose-1-phosphate uridylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
gpsAGlycerol-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (338 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (147 aa)
pgkPhosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (398 aa)
ackASAM-dependent methyltransferase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa)
glmSGlutamine--fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (604 aa)
tktTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (658 aa)
fgs_2Dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. (441 aa)
queHDNA integration/recombination/inversion protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (255 aa)
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (738 aa)
fclHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (593 aa)
ARC26971.1Phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
hepCOligohyaluronate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (632 aa)
gpmA_1Histidine phosphatase family protein; Frameshifted; internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
pyrG_2CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (536 aa)
gutBButanediol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
deoD_2Phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
A6J72_07980NAD(P)-dependent oxidoreductase; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (133 aa)
ARC27108.1Glycosyl transferase family 8; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
pksGhydroxymethylglutaryl-CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
pyrDADihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate. (311 aa)
fabZbeta-hydroxyacyl-ACP dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (140 aa)
accCacetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (455 aa)
accDacetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (287 aa)
accACytochrome O ubiquinol oxidase; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (256 aa)
nagAN-acetylglucosamine-6-phosphate deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
mraYPeptide ABC transporter ATP-binding protein; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (327 aa)
pyrG_1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
uppPUndecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (280 aa)
dacA_1D-alanyl-D-alanine carboxypeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S11 family. (413 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (208 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (165 aa)
murDUDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (450 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (356 aa)
murEUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan; Belongs to the MurCDEF family. MurE subfamily. (481 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa)
glmUUDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (459 aa)
nudFADP-ribose pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
mtnN5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (246 aa)
queAtRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (342 aa)
nagBGlucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (235 aa)
dacA_2Peptidase S11; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S11 family. (452 aa)
femAPeptidoglycan branched peptide synthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (412 aa)
ARC26152.1Phosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
pgl6-phosphogluconolactonase; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
ARC27412.1AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
ARC26104.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
pspBHistidine phosphatase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
A6J72_01960ATPase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
ARC26073.1Glycosyl hydrolase family 25; Derived by automated computational analysis using gene prediction method: Protein Homology. (279 aa)
tpiA_1Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa)
rpiARibose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (227 aa)
punAPurine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (269 aa)
deoD_1Purine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
ltaS2Alkaline phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (724 aa)
ARC27405.1Calcium-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa)
rmlDdTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (283 aa)
rfbCdTDP-4-dehydrorhamnose 3,5-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
rmlBdTDP-glucose 4,6-dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (348 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (279 aa)
ndkNucleoside-diphosphate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (362 aa)
carBCarbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family. (1059 aa)
glcKGlucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
FlaRTopology modulation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (169 aa)
coaAType I pantothenate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
deoAPyrimidine-nucleoside phosphorylase; Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa)
deoC1Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (220 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (129 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (434 aa)
ldhAL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (327 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (193 aa)
ARC25877.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (519 aa)
nrdD_1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
ARC25842.1RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0109 family. (79 aa)
murABUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (424 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (197 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (209 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (231 aa)
pyrDBDihydroorotate dehydrogenase B catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (312 aa)
pyrKDihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (268 aa)
mvaAhydroxymethylglutaryl-CoA reductase, degradative; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HMG-CoA reductase family. (426 aa)
gndPhosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (474 aa)
murCUDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (443 aa)
mltGAminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (534 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (264 aa)
bcrCPhosphatase PAP2 family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
ARC27164.1NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Nudix hydrolase family. (149 aa)
gpmA_2Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (230 aa)
penAPenicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (682 aa)
ddlD-alanine--D-alanine ligase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (348 aa)
murFUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (456 aa)
lacD2Tagatose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldolase LacD family. (315 aa)
lacC_2Phosphofructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (310 aa)
ARC27228.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
atpEF0F1 ATP synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (66 aa)
atpBF0F1 ATP synthase subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (237 aa)
atpFATP synthase F0 subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (164 aa)
atpHF0F1 ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (178 aa)
atpAF0F1 ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (501 aa)
atpGF0F1 ATP synthase subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (292 aa)
atpDATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (468 aa)
atpCF0F1 ATP synthase subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (139 aa)
murAAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (426 aa)
ARC27266.1DNA-directed RNA polymerase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (58 aa)
ARC27270.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
Your Current Organism:
Streptococcus intermedius
NCBI taxonomy Id: 1338
Other names: ATCC 27335, CCUG 17827, CCUG 32759, CIP 103248, DSM 20573, JCM 12996, LMG 17840, LMG:17840, NCDO 2227, NCTC 11324, S. intermedius, VPI 3372A, strain SK 54, strain SK54
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