STRINGSTRING
A6J72_08780 A6J72_08780 recD2 recD2 ARC26513.1 ARC26513.1 tsaB tsaB ARC27423.1 ARC27423.1 rnjA rnjA rpsG rpsG rnmV rnmV ARC26537.1 ARC26537.1 rnpA rnpA tadA tadA rpsB rpsB znuB znuB znuC_1 znuC_1 ntpD ntpD ntpB ntpB ntpA ntpA ntpC ntpC ARC26583.1 ARC26583.1 ntpK ntpK NtpI NtpI murR murR rpiR rpiR lacF_2 lacF_2 ruvB ruvB prs prs mfd mfd dnaN dnaN dnaC dnaC ARC26721.1 ARC26721.1 dltA dltA CadX CadX rpmF rpmF malR malR malF malF malX malX mutS mutS mutL mutL ruvA ruvA ARC26782.1 ARC26782.1 nrdD_1-2 nrdD_1-2 saeR saeR glvR glvR ARC26814.1 ARC26814.1 rplB rplB rpsS rpsS rpsC rpsC rplN rplN rplE rplE rpsH rpsH rpsE rpsE rpmD rpmD rplO rplO secY secY rpsK rpsK rpoA rpoA gpsA gpsA dut dut rpoB rpoB rpoC rpoC xpsE xpsE comGC comGC ARC26880.1 ARC26880.1 ARC26882.1 ARC26882.1 ARC26884.1 ARC26884.1 proS proS ARC26902.1 ARC26902.1 ARC26904.1 ARC26904.1 ARC26906.1 ARC26906.1 ARC26908.1 ARC26908.1 pheT_2 pheT_2 groL groL znuC_2 znuC_2 pimA pimA ARC26962.1 ARC26962.1 ARC27440.1 ARC27440.1 rpsO rpsO ARC26971.1 ARC26971.1 sugC sugC rpsI rpsI ARC26995.1 ARC26995.1 kdgR kdgR rpoE rpoE oppC oppC degA degA secA secA recG_2 recG_2 codY codY gatA gatA gatB gatB salL salL deoD_2 deoD_2 ykoD_2 ykoD_2 arlR_2 arlR_2 DnaB DnaB dnaI dnaI ARC27131.1 ARC27131.1 ARC27147.1 ARC27147.1 ARC27170.1 ARC27170.1 A6J72_08340 A6J72_08340 xseA xseA xseB xseB mutS2 mutS2 pepD pepD ARC26474.1 ARC26474.1 licA_3 licA_3 ykoD_1 ykoD_1 fabM fabM FabK FabK accB accB accC accC accD accD accA accA trmB trmB nagA nagA ARC26383.1 ARC26383.1 ARC26382.1 ARC26382.1 ARC27420.1 ARC27420.1 ARC26379.1 ARC26379.1 glyQ glyQ ktrA ktrA nifU nifU nadE nadE ahpF ahpF gmk gmk rpoZ rpoZ priA priA rsmB rsmB yugI yugI A6J72_03075 A6J72_03075 cysK cysK yigZ yigZ hpf hpf typA typA ARC26270.1 ARC26270.1 tqsA_1 tqsA_1 ARC26244.1 ARC26244.1 dnaX_1 dnaX_1 sdpR sdpR A6J72_02715 A6J72_02715 graR graR bceB bceB rplK rplK rplA rplA ARC26190.1 ARC26190.1 smc_1 smc_1 ARC26131.1 ARC26131.1 licA_2 licA_2 pepDA pepDA nrdE nrdE uvrC uvrC ARC26083.1 ARC26083.1 ylaC ylaC RgpA RgpA tagG tagG pglJ pglJ ccpA ccpA dgs dgs mgs mgs yycF_2 yycF_2 yycJ yycJ ccpN ccpN iscS_1 iscS_1 clcA_1 clcA_1 clpX clpX uvrB uvrB ARC25967.1 ARC25967.1 pyrB pyrB carA carA arlR_1 arlR_1 rpsT rpsT xylG xylG eno eno rpsA_1 rpsA_1 gyrA gyrA dnaG dnaG sigA sigA clcA_2 clcA_2 guaC guaC ffh ffh ARC25870.1 ARC25870.1 ARC25869.1 ARC25869.1 rnhB rnhB nrdD_1 nrdD_1 comEA comEA dgkA dgkA ARC25802.1 ARC25802.1 birA birA dnaX_2 dnaX_2 tetD tetD potA potA perR perR strH strH lacF_1 lacF_1 nrnA_1 nrnA_1 tqsA_2 tqsA_2 alsS alsS ARC27231.1 ARC27231.1 rexB rexB addA addA GlgB GlgB glgC glgC glgD glgD ARC27252.1 ARC27252.1 rnhC rnhC atpE atpE atpB atpB atpF atpF atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC ARC27266.1 ARC27266.1 dnaD dnaD dnaE dnaE pfkA pfkA pcrA pcrA RadC RadC iscS_2 iscS_2 prs2 prs2 pta pta coaBC_2 coaBC_2 coaBC_1 coaBC_1 ARC27349.1 ARC27349.1 rnjB rnjB ARC27379.1 ARC27379.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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A6J72_08780Triacylglycerol lipase; Incomplete; partial on complete genome; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
recD2Exodeoxyribonuclease V subunit alpha; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (784 aa)
ARC26513.1IS30 family transposase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (94 aa)
tsaBtRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa)
ARC27423.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0356 family. (76 aa)
rnjARibonuclease J; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (560 aa)
rpsG30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rnmVRibonuclease M5; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. (190 aa)
ARC26537.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (93 aa)
rnpARibonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (119 aa)
tadAtRNA-specific adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (155 aa)
rpsB30S ribosomal protein S2; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS2 family. (260 aa)
znuBZinc ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
znuC_1Zinc ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
ntpDV-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (207 aa)
ntpBV-type ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (463 aa)
ntpAV-type ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (596 aa)
ntpCV-type ATP synthase subunit C; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa)
ARC26583.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (196 aa)
ntpKV-type ATP synthase subunit K; Produces ATP from ADP in the presence of a proton gradient across the membrane; the K subunit is a nonenzymatic component which binds the dimeric form by interacting with the G and E subunits; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the V-ATPase proteolipid subunit family. (159 aa)
NtpIV-type ATP synthase subunit I; Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I is part of the membrane proton channel; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the V-ATPase 116 kDa subunit family. (652 aa)
murRMurR/RpiR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
rpiRRpiR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
lacF_2Acetylneuraminate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
ruvBHolliday junction branch migration DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (332 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (322 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1164 aa)
dnaNDNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (378 aa)
dnaCReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (450 aa)
ARC26721.1Molecular chaperone; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
dltAD-alanine--poly(phosphoribitol) ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-de [...] (516 aa)
CadXTranscriptional regulator; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
rpmF50S ribosomal protein L32; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL32 family. (60 aa)
malRLacI family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
malFSugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
malXSugar ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (420 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (852 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (648 aa)
ruvAHolliday junction branch migration protein RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (197 aa)
ARC26782.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0473 family. (101 aa)
nrdD_1-2Anaerobic ribonucleoside-triphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (736 aa)
saeRDNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
glvRMurR/RpiR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
ARC26814.1AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (277 aa)
rpsS30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa)
rpsC30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (217 aa)
rplN50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa)
rpsH30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rpsE30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (164 aa)
rpmD50S ribosomal protein L30; Derived by automated computational analysis using gene prediction method: Protein Homology. (74 aa)
rplO50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
secYPreprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (435 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (127 aa)
rpoADNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (312 aa)
gpsAGlycerol-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (338 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (147 aa)
rpoBDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1188 aa)
rpoCDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1212 aa)
xpsECompetence protein CglA; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
comGCCompetence protein ComG; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
ARC26880.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
ARC26882.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
ARC26884.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
proSproline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacy [...] (619 aa)
ARC26902.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (95 aa)
ARC26904.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
ARC26906.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (129 aa)
ARC26908.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
pheT_2tRNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (208 aa)
groLChaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (540 aa)
znuC_2Manganese ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
pimAGlycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
ARC26962.1Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
ARC27440.1DUF4832 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (442 aa)
rpsO30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
ARC26971.1Phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
sugCABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. (376 aa)
rpsI30S ribosomal protein S9; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS9 family. (130 aa)
ARC26995.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (348 aa)
kdgRTranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
rpoEDNA-directed RNA polymerase subunit delta; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family. (195 aa)
oppCPeptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (308 aa)
degALacI family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
secAPreprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (839 aa)
recG_2ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (671 aa)
codYGTP-sensing pleiotropic transcriptional regulator CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. (262 aa)
gatAaspartyl/glutamyl-tRNA amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (488 aa)
gatBaspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (477 aa)
salLDNA-directed RNA polymerase subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
deoD_2Phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
ykoD_2Heme ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
arlR_2DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
DnaBTranscriptional regulator NrdR; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
dnaIPrimosomal protein that may act to load helicase DnaC during DNA replication; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
ARC27131.1RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1036 aa)
ARC27147.1Phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
ARC27170.1Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
A6J72_08340Multidrug ABC transporter ATP-binding protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
xseANAD(P)H-hydrate dehydratase; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (446 aa)
xseBExodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (70 aa)
mutS2Endonuclease MutS2; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (777 aa)
pepDDipeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
ARC26474.1Zn-dependent protease; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
licA_3TetR family transcriptional regulator; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
ykoD_1ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (444 aa)
fabMenoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa)
FabK[acyl-carrier-protein] S-malonyltransferase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
accBacetyl-CoA carboxylase biotin carboxyl carrier protein subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (159 aa)
accCacetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (455 aa)
accDacetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (287 aa)
accACytochrome O ubiquinol oxidase; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (256 aa)
trmBtRNA (guanosine(46)-N7)-methyltransferase TrmB; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (211 aa)
nagAN-acetylglucosamine-6-phosphate deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
ARC26383.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (208 aa)
ARC26382.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (982 aa)
ARC27420.1Restriction endonuclease subunit S; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
ARC26379.1Type I restriction-modification system subunit M; Derived by automated computational analysis using gene prediction method: Protein Homology. (535 aa)
glyQglycine--tRNA ligase subunit beta; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (304 aa)
ktrAPotassium transporter Trk; Derived by automated computational analysis using gene prediction method: Protein Homology. (221 aa)
nifUIron-sulfur cluster assembly scaffold protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
nadENAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (274 aa)
ahpFAlkyl hydroperoxide reductase subunit F; Derived by automated computational analysis using gene prediction method: Protein Homology. (510 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (208 aa)
rpoZDNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (104 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (793 aa)
rsmB16S rRNA (cytosine(967)-C(5))-methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (437 aa)
yugIRNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
A6J72_03075Cell filamentation protein Fic; Internal stop; incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (64 aa)
cysKCysteine synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (309 aa)
yigZDNA/RNA helicase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
hpfRibosomal subunit interface protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (180 aa)
typAGTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology. (613 aa)
ARC26270.1RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa)
tqsA_1AI-2E family transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
ARC26244.1Acetoin utilization protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
dnaX_1DNA polymerase III subunit delta; Catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
sdpRHemolysin expression modulating protein; Incomplete; partial on complete genome; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (67 aa)
A6J72_02715Hypothetical protein; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
graRDNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
bceBPeptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (662 aa)
rplK50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (229 aa)
ARC26190.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
smc_1ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (1121 aa)
ARC26131.1Metallophosphatase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
licA_2PTS lactose/cellobiose transporter subunit IIA; Derived by automated computational analysis using gene prediction method: Protein Homology. (107 aa)
pepDAHypothetical protein; Frameshifted; internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (674 aa)
nrdERibonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (719 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (602 aa)
ARC26083.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (138 aa)
ylaCRNA polymerase subunit sigma-70; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (156 aa)
RgpAGlycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
tagGLPS ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
pglJGlycosyl transferase family 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (583 aa)
ccpACatabolite control protein A; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
dgsGlycosyl transferase family 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
mgs1,2-diacylglycerol 3-glucosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (437 aa)
yycF_2DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (233 aa)
yycJHypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
ccpNTranscriptional repressor CcpN; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
iscS_1Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
clcA_1Voltage-gated chloride channel protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
clpXATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (410 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (662 aa)
ARC25967.1RNase adaptor protein RapZ; Displays ATPase and GTPase activities. (296 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (362 aa)
arlR_1DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
rpsT30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (78 aa)
xylGHeme ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (511 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (434 aa)
rpsA_130S ribosomal protein S1; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (815 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (599 aa)
sigARNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (370 aa)
clcA_2ClC family H(+)/Cl(-) exchange transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (519 aa)
guaCGuanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (327 aa)
ffhSignal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (524 aa)
ARC25870.1Carbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
ARC25869.1Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (246 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (255 aa)
nrdD_1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
comEACompetence protein CelA; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
dgkAUDP kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
ARC25802.1Competence protein TfoX; Derived by automated computational analysis using gene prediction method: Protein Homology. (106 aa)
birABifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (311 aa)
dnaX_2DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (554 aa)
tetDAraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
potASpermidine/putrescine ABC transporter ATP-binding protein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (385 aa)
perRTranscriptional repressor; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Fur family. (153 aa)
strHGlycoside hydrolase family 2; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycosyl hydrolase 2 family. (2222 aa)
lacF_1PTS lactose transporter subunit IIA; Catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; Derived by automated computational analysis using gene prediction method: Protein Homology. (106 aa)
nrnA_1DHH family phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (312 aa)
tqsA_2AI-2E family transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (392 aa)
alsSAcetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (554 aa)
ARC27231.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (539 aa)
rexBATP-dependent nuclease subunit B; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity; Belongs to the helicase family. AddB/RexB type 2 subfamily. (1090 aa)
addAHelicase-exonuclease AddAB subunit AddA; ATP-dependent DNA helicase. (1226 aa)
GlgB1,4-alpha-glucan branching enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (636 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (380 aa)
glgDGlucose-1-phosphate adenylyltransferase subunit GlgD; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
ARC27252.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
rnhCRibonuclease HIII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (296 aa)
atpEF0F1 ATP synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (66 aa)
atpBF0F1 ATP synthase subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (237 aa)
atpFATP synthase F0 subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (164 aa)
atpHF0F1 ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (178 aa)
atpAF0F1 ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (501 aa)
atpGF0F1 ATP synthase subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (292 aa)
atpDATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (468 aa)
atpCF0F1 ATP synthase subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (139 aa)
ARC27266.1DNA-directed RNA polymerase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (58 aa)
dnaDHomoserine O-succinyltransferase; Frameshifted; internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
dnaEGntR family transcriptional regulator; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (1033 aa)
pfkAATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (336 aa)
pcrADNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology. (760 aa)
RadCHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0758 family. (226 aa)
iscS_2Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
prs2Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (323 aa)
ptaPhosphate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
coaBC_2Phosphopantothenoylcysteine decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
coaBC_1Phosphopantothenate--cysteine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
ARC27349.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
rnjBRibonuclease J; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (553 aa)
ARC27379.1UDP-N-acetylmuramyl peptide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (447 aa)
Your Current Organism:
Streptococcus intermedius
NCBI taxonomy Id: 1338
Other names: ATCC 27335, CCUG 17827, CCUG 32759, CIP 103248, DSM 20573, JCM 12996, LMG 17840, LMG:17840, NCDO 2227, NCTC 11324, S. intermedius, VPI 3372A, strain SK 54, strain SK54
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