STRINGSTRING
hisI hisI hisF hisF BD94_1326 BD94_1326 hisA hisA BD94_1328 BD94_1328 hisH hisH hisB hisB hisC hisC hisD hisD hisG hisG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
hisIPhosphoribosyl-AMP cyclohydrolase / Phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. (195 aa)
hisFImidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa)
BD94_1326Hypothetical protein. (221 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (238 aa)
BD94_1328Tricorn protease homolog; Degrades oligopeptides; Belongs to the peptidase S41B family. (1058 aa)
hisHImidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (192 aa)
hisBHistidinol-phosphatase / Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (377 aa)
hisCHistidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (343 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (439 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (284 aa)
Your Current Organism:
Elizabethkingia anophelis
NCBI taxonomy Id: 1338011
Other names: E. anophelis NUHP1, Elizabethkingia anophelis NUHP1
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